522 randomized controlled trials involving 21 antidepressants and 116,477 people were analyzed. It appears the most effective antidepressants (at a duration of 8 weeks) include amitriptyline, escitalopram, mirtazapine, paroxetine, and venlafaxine.
While reboxetine and trazodone had notably lower efficacy ratings. Some of the most effective drugs had lower tolerability scores, however, indicating they may have a greater side effect burden.
The antidepressant literature shows signs of potential bias, so the results have to be considered with that in mind.
More detailed overview: https://thedrugclassroom.com/overview-least-effective-antidepressants/
Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/8cg969/overview_the_most_and_least_effective/
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