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Septic shock - pathophysiology and symptoms | NCLEX-RN | Khan Academy

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Created by Ian Mannarino. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-cardiovascular-diseases/rn-shock-2/v/septic-shock-diagnosis-and-treatment?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-cardiovascular-diseases/rn-shock-2/v/sepsis-sirs-mods?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
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Текстовые комментарии (115)
You Know Who (19 дней назад)
My mom died of Sepsis last week 😔
itsyaboymiks (1 месяц назад)
Great teaching like this makes me eager to learn more :) thank you!
Ohnolillam (1 месяц назад)
So good!! Thanks!!
lock dot 2 (1 месяц назад)
I thought it was not searese i have it i was diagnosis yesterday im scard now
Bianca Ro (1 месяц назад)
Te amo. Me salvaste la vida ❤️🙏🏽
Merida Dream (2 месяца назад)
Thank uuuuu ☺️🙏🏼
Cr33p (2 месяца назад)
Oh god I just listened to this and now I just wanna die. What a horrific way to die.
Caiyll (2 месяца назад)
My grandpa is fighting septic shock right now. His kidney and liver has failed already. Septic Shock is no joke.
Alonso Iriarte Wachtendorff (2 месяца назад)
Finally understood, your explaining is so comprehensive
MrGoblin60 (3 месяца назад)
Thanks Doc. This is so eloquently yet simply articulated. Excellent presentation.
Josh G (3 месяца назад)
Clear and precise explanation indeed. Thanks much for sharing your knowledge.
Lindsey Atkins (4 месяца назад)
This is happening to me over and over and it has damged so much of my tissues all over and lost alot of tissue everywhere. And no one believes me . I'm very sick and on fire and feel severely dried out and my skin is peeling off, my tissues swelled for so long and turned cold and clammy and fluid would start leaking out of my skin I cant breath and my head feels like Iv been drinking no one is listening and im fighting for my life
Nick Webster (5 месяцев назад)
This video was extremely informative, well explained, and very helpful!
Nout ayyash (7 месяцев назад)
everything is clear about sepsis in less than 10 min vid! thank you.
iliketoreid (7 месяцев назад)
This video helped me so much to understand septic shock! Thank you! I always watch it when I need a review! I recommend it to anyone who is struggling to understand the topic!
Sam Hussein (7 месяцев назад)
Perfect 👌🏻
ivan susilla (7 месяцев назад)
Do you think tramadol and temazepam had something to do with sepsis?
Channell 110 (8 месяцев назад)
Good presentation but there is always a problem of low voice in videos please solve this problem in the next videos
Hampus Larsson (8 месяцев назад)
Thank you for this video! I have had septis chock, and this was very helpfull To understand it
Susan Golian (9 месяцев назад)
This is a splendidly informative video. Thank you SO much!
Dr Balram Ji Omar (10 месяцев назад)
wonderfully explained
jocy galvan (10 месяцев назад)
omg you totally saved my ass on my homework in nursing school plus i actually understood the process where as reading two pathophysiology books i couldnt understand it well enough so thank you somuch what would i do without youtube?
Agata Ramesh (10 месяцев назад)
I thought nitrous oxide was a laughing gas. is he maybe  meaning nitric oxide
Khamis Zananiri (10 месяцев назад)
excellent.thanks sir
Yousaf Anwar (11 месяцев назад)
Why is the effective material in the interstitial fluid"
Siva Mahalingam (11 месяцев назад)
Fantastic video,
anonymous !! (11 месяцев назад)
best video.... excellent explanation....really got to know the importance of the topic
Helena Halasz (1 год назад)
Thanks for the awesome videos! Quick ques: you said that the WBC release NO? I thought the endothelial cells are the ones that would release nitric oxide, thus causing the vasodilation? (Also, maybe if you could discuss the role of LPS in a future video, that would be great :) )
udaya udaya ranasinghe seneviratne (1 год назад)
I. Would.
Benjamin Washington (1 год назад)
Awesome video!
LETMEC4FREE (1 год назад)
This is dynamite, thank you!!!!
Rob Kranz (1 год назад)
Go Kahn
Luke Histon (1 год назад)
Muhammad Ali died from this
Amber Shaw (1 год назад)
This is brilliant thank you. Just helped me really understand septic shock in time for my OSCE!
K Jugs (1 год назад)
Wait I have a question. So technically when you have blood infection, WBCs are useless and would even cause your death? I had a blood infection once from UTI, had a 3-day fever but then it settled down after I took localized antibiotics. But the doctor said those antibiotics I took are for my kidneys; wonder how it 'cured' the infection in my blood.
Precious Ohagwu (1 год назад)
Probably because the organism causing your UTI was not localized to the urinary system anymore and had moved upwards to your kidneys causing what is called pyelonephritis which is basically inflammation of your kidneys.The systemic antibiotic cleared up the bugs in both your kidneys and urinary tract. Hope this helps!
Allison Wayman (1 год назад)
oh my God this exactly what happened to my husband that resulted in his death with in 2 weeks of being diagnosed.
Beth Michael (4 месяца назад)
My ex died from it because of a hernia. My mom died from it from poor circulation, her leg turned blackish 💔
Momento Mori (1 год назад)
god bless his soul
Nesrine Saoudi (1 год назад)
WHAT A NICE JOB ! thank you
kevykev913 (1 год назад)
interesting even for the layman
Courtney Tewary (1 год назад)
Jenna White (1 год назад)
You're the best!! Your videos make it SO much clearer. You're an excellent teacher. Thank you so much for taking the time to make and post these. :)
Samuel Chase Shoptaw (1 год назад)
Mr Nullius Testikleez Eeasteez (1 год назад)
This, I reckon, is the best video on septic shock I've ever seen.
Lauren Stewart (1 год назад)
Kamran Boka (1 год назад)
Correction: @2:19 "nitric" oxide not nitrous oxide. Great video!
FrankieBeans (1 год назад)
my father just had a distributive shock 2 days ago they are saying it could possibly be septic I just listened to the first couple seconds of the video and my heart just dropped. the doctor said they may possibly be bacteria on one of the lines of the pacemaker he has on his heart .
KeN SmilePachI (1 год назад)
FrankieBeans Please tell us what happened after, I hope your father is safe and sound at the moment.
Diamond Roses (1 год назад)
FrankieBeans Awww. I'm sorry to hear that. I really hope that he has a had a nice recovery.
Ernest Whilhem (1 год назад)
This video should be used by kindergarten kids, not medical students. Basic "information" with many errors. Thanks for wasting my time.
Morning Glory (1 месяц назад)
If you have such a brilliant medical mind, why are you watching medical tutorial videos on youtube in the first place?
Ragu Hari (1 год назад)
Haha.. Can kindergarten even understand?? This is just a negative criticism..
Tristen Hafner-Eaton (1 год назад)
If you are going to point out errors with it, you have a responsibility to specify exactly what is wrong in the video. Khan academy can't learn from their errors with non-constructive criticism. What exactly is wrong with this video? I believe it shows a very basic, but good "first step" understanding of what septic shock is...which is all it is meant to do.
Luke Fenech (1 год назад)
This is the best explanation of sepsis I have found so far. Thank you very much.
Nifty Dude (1 год назад)
I just got septic shock recently due to pneumonia and it was hell. my mom is a nurse so she was able to send me to the hospital and caught the septic shock very early on. I was only in the ICU a week but it was terrible. I'm 15 and never had an experience quite so insane ever before, and I would never wish an experience like this on anyone ever.
Nooruddin Quadri (2 года назад)
explain the two types of septic shock.....warm and hyperdynamic.
khald elsherbiny (2 года назад)
very good
first class roadman (2 года назад)
great video extremely helpful.i have an alternative explanation would like to confirm with you or anyone else is welcome .if CO=HRxSV and SV is affected by peripheral vascular resistance ( PVR), NO causes dilation decreasing PVR decreasing venous return also taking into consideration increased vascular permeability .could SV be reduced?resulting in tachycardia to maintain CO?is that not a symptom worth mentioning or does it fall vaguely under RDS related symptoms ? but once again great video ,i have just subscribed!
petr petrich (2 года назад)
Please tell me why do WBCs release lytic sybstances in the blood stream itself when trying to damage pathogen? Why don't they phagocytose them to lyse them safely without damaging outer tissues? Thank you!
petr petrich (2 года назад)
Are they destroyed normally that way? I mean WBCs with phagosomes inside. So why don't they damage our vessels' walls when we have pathogens without onset of sepsis?
Ghada Karim (2 года назад)
petr petrich they do phagocytose them and secrete lytic enzymes on them inside the WBC and when they are destroyed the WBC will be destroyed as well and so the lytic enzymes are now outside the cell and they cause damage to the blood vessel walls.
ayoud. (2 года назад)
Rest in piece Muhammad Ali.
Mandana Mashoof (2 года назад)
Thank you so much. You explained this great.
tere williams (2 года назад)
Please understand decreased tissue oxygenation.. Time is of the essence when dealing on this level..  Be aware and move on it please.  Better safe than sorry.  White blood cells must get into interstitial tissue to fight this internal war.  These are All great info for all to know.  Systematic vascular resistance with this particular situation and more.
agmuhammad (2 года назад)
Just brilliant preview and explanation . you should add that Many Metastatic cancer Cells in the blood stream could cause a fast sever SEPSIS , and eventually death ! it usually happens at the advanced stages of cancer or with some aggressive cancers like Pancreas CA or , Biliary CA.
Burnin Sage (2 года назад)
Great job! Thank You !!!
Kayalvizhi Duraisamy (2 года назад)
Isnt there any role played by Endotoxins and its formation of a complex with LBP?
Ragu Hari (1 год назад)
Kayalvizhi Duraisamy I think it has a role..
Gerry Winters (2 года назад)
I had 2 prostate  surgeries 4 months ago followed by Septic Shock 8 days later.  One day my wife found me on the kitchen floor.  The surgeries were a Sunday picnic compared to Septic Shock.  It was a hell I hope I  never see again. I still measure my blood oxygen and pulse per minute, and blood pressure 3 times a day.  I consider myself a pretty tough guy but I  still cry every day  and I cant control it. I cried in the hospital several times a day every day. A nurse would walk in and say Good Morning and I would cry.
ice Devil (4 месяца назад)
How are u now? I wish y’all good health and strength
Scott S (8 месяцев назад)
I am a very recent survivor of sepsis and I am going through a rough time with my mental health as my body is recovering. I thank you for the comments.
Ragu Hari (1 год назад)
I wish this 2018 may give you all good health and wellness.. stay blessed..
Gerry Winters (2 года назад)
I have prostate cancer. Septic Shock made me welcome death. I hope you never suffer again and stay healthy. God bless you.
MsCerise007 (2 года назад)
I hear ya!!! I'm crying reading this. I too had sepsis & sepsis shock & had a knee joint operation & 2 months later this crazy shit. My temp was 108. I am actually afraid of death now after reading & watching sepsis videos. I hope I never get this disease from hell again. Do you have cancer?
Ali Kulz (2 года назад)
I have my shock exam next week. This is the resource that summarises all text books I have read
anderw andrew (2 года назад)
Metabolic Theory of Septic Shock Please do a search for the above Core tip: For decades septic shock has been attributed to an over-active immune response. However, immune modulation has failed to reduce mortality, casting doubt on a direct causal role for the immune response in the development of septic shock. A closer look suggests that septic shock is the result of a generalized build-up of hydrogen peroxide, a toxic cellular by-product generated as a consequence of the hypermetabolic state that accompanies a systemic immune response. This finding points to the systemic accumulation of hydrogen peroxide as a significant risk factor for the development of septic and non-septic shock syndromes.
Mia (2 года назад)
+anderw andrew I'll make sure to search for this. Thank you so much ! :)
Reem Hussain (2 года назад)
the best explanation ever! u are really talented , thank u so much
Raul Rodriguez (2 года назад)
Good explanation!!!! I already understood some mechanisms related to septic shock. Thanks so much
Ashley Balitaan (3 года назад)
*NITRIC* oxide causes vasodilation
Anita Contarini (3 года назад)
ale (3 года назад)
The nitrous oxide cause the vasodilation? But what about the prostaglandines, and other inflamatory factors that increase the vascular permeability?
ale (2 года назад)
+TheUmmaHope yeah, I understand that. I was just saying that there are other factor involved
Mia (2 года назад)
+ale NO is actually THE most powerful vasodilator of the body so, I guess, that's why he's talking ainly about it.
April Dii (3 года назад)
+ale i think he meant nitrous oxide as just ONE of the many factors or molecules being released. I'm pretty sure what you mentioned will also be a factor considering the worsening condition of a patient. :)
Mi The Y (3 года назад)
What about the causative agent and its mechanism in causing septic shock, like the LPS ,gram -ive bacteria and All that things?
Abood Albouq (3 года назад)
Thank you very much :) ... i will never forget the meaning of septic shock after this diagram
shaza AA (3 года назад)
Thank you , good explaining 👏🏽
Brad Jones (3 года назад)
Didn't mention the lactic acid buildup in the cells due to anaerobic metabolism...
Zahid Berke Aygin (18 дней назад)
eventually cells are gonna die, the lactic acid produced from aneurobic glikolysis (cells cant oxygenate) is going to pour to the blood. Thus you can see lactic acid in the blood both due to this mechanism and less cleaning of the substance
james davies (2 месяца назад)
ice Devil Decreased tissue perfusion is something that happens in all types of shock. If there is less tissue perfusion, the tissues have less oxygen, so they have to turn to anaerobic metabolism, which creates lactic acid as a byproduct.
ice Devil (4 месяца назад)
Ragu Hari I didn’t know that ..
Ragu Hari (1 год назад)
Brad Jones it's obvious in any kind of shock dude
Suprateeka T (3 года назад)
Dee gonzalez (3 года назад)
AMAZING!!!!! So clear and thoroughly explained!!!! Thank you!
Vanessa C (3 года назад)
So the your blood vessels dilate because of the nitrous oxide and other molecules released from WBC, and that's why you get hypotension in septic shock. Is that correct?
Mihir Thosar (3 года назад)
malirsal (3 года назад)
Thanks a lot, I personally searched this in books and couldn't understand it as well as i did here. I was afraid probably of the "unaccuracy" of the terms, but for real all was very precise and helpful. Again, thanks a lot.
SoshiHogosha4 (3 года назад)
At last I understand Septic shock! Thank you so much!!
Lea Reeves (3 года назад)
OMG just brilliant. thank you so much.
Nimra Aslam (3 года назад)
mia hayes (3 года назад)
What an excellent video! all the important main points explained clearly within 8mins buy if I read this in a book it would have taken me 1 hour. The visual diagrams really helps to understand.
Mix Loads (1 год назад)
Sepsis and Septic shock newer #guidelines http://www.curemycase.com/the-third-international-consensus-definitions-for-sepsis-and-septic-shock-sepsis-3/
TM (3 года назад)
Exactly what I needed! :D
nalauj127 (3 года назад)
I'm confused. So normally the infected material is in the tissues so the white blood cells need to move from the blood vessels into the tissue by making the blood vessel leaky. But now that the infection is the blood vessel how will that cause leakiness elsewhere? Is it because of the toxins released by the white blood cells also make it leaky?
Mi The Y (3 года назад)
+Brad Jones that makes sense thx
Brad Jones (3 года назад)
+Alaina Lo When the infection is localized to a tissue then specific cells inside the tissue can secrete cytokines that "call" the WBC's to that area. When the WBC's get to that area they bind to selectins in the endothelial membrane and "roll" into the tissues. So it is quite a bit more coordinated than the widespread infection. When the infection gets into your blood, it goes EVERYWHERE. That is why your body responds with vasodilation EVERYWHERE and not just localized. Does that makes sense?
Vanessa C (3 года назад)
+Alaina Lo I was wondering the same thing LOL!
Gary Richardson (3 года назад)
I'm not sure I wanted to know all of that but it is what it is. Thank you it was very informative .
K Bui (3 года назад)
thank you so much
moch50 (4 года назад)
Nice detail, my textbook in visual form
Neha Patel (4 года назад)
I absolutely love the way everything is explained here. 
brownmolasses (4 года назад)
Excellent explanation!

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