Created by Ian Mannarino.
Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-cardiovascular-diseases/rn-shock-2/v/septic-shock-diagnosis-and-treatment?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn
Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-cardiovascular-diseases/rn-shock-2/v/sepsis-sirs-mods?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn
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This is happening to me over and over and it has damged so much of my tissues all over and lost alot of tissue everywhere. And no one believes me . I'm very sick and on fire and feel severely dried out and my skin is peeling off, my tissues swelled for so long and turned cold and clammy and fluid would start leaking out of my skin I cant breath and my head feels like Iv been drinking no one is listening and im fighting for my life
omg you totally saved my ass on my homework in nursing school plus i actually understood the process where as reading two pathophysiology books i couldnt understand it well enough so thank you somuch what would i do without youtube?
Thanks for the awesome videos! Quick ques: you said that the WBC release NO? I thought the endothelial cells are the ones that would release nitric oxide, thus causing the vasodilation? (Also, maybe if you could discuss the role of LPS in a future video, that would be great :) )
Wait I have a question. So technically when you have blood infection, WBCs are useless and would even cause your death? I had a blood infection once from UTI, had a 3-day fever but then it settled down after I took localized antibiotics. But the doctor said those antibiotics I took are for my kidneys; wonder how it 'cured' the infection in my blood.
Probably because the organism causing your UTI was not localized to the urinary system anymore and had moved upwards to your kidneys causing what is called pyelonephritis which is basically inflammation of your kidneys.The systemic antibiotic cleared up the bugs in both your kidneys and urinary tract. Hope this helps!
my father just had a distributive shock 2 days ago they are saying it could possibly be septic I just listened to the first couple seconds of the video and my heart just dropped.
the doctor said they may possibly be bacteria on one of the lines of the pacemaker he has on his heart .
If you are going to point out errors with it, you have a responsibility to specify exactly what is wrong in the video. Khan academy can't learn from their errors with non-constructive criticism. What exactly is wrong with this video? I believe it shows a very basic, but good "first step" understanding of what septic shock is...which is all it is meant to do.
I just got septic shock recently due to pneumonia and it was hell. my mom is a nurse so she was able to send me to the hospital and caught the septic shock very early on. I was only in the ICU a week but it was terrible. I'm 15 and never had an experience quite so insane ever before, and I would never wish an experience like this on anyone ever.
great video extremely helpful.i have an alternative explanation would like to confirm with you or anyone else is welcome .if CO=HRxSV and SV is affected by peripheral vascular resistance ( PVR), NO causes dilation decreasing PVR decreasing venous return also taking into consideration increased vascular permeability .could SV be reduced?resulting in tachycardia to maintain CO?is that not a symptom worth mentioning or does it fall vaguely under RDS related symptoms ? but once again great video ,i have just subscribed!
Please tell me why do WBCs release lytic sybstances in the blood stream itself when trying to damage pathogen? Why don't they phagocytose them to lyse them safely without damaging outer tissues? Thank you!
petr petrich they do phagocytose them and secrete lytic enzymes on them inside the WBC and when they are destroyed the WBC will be destroyed as well and so the lytic enzymes are now outside the cell and they cause damage to the blood vessel walls.
Please understand decreased tissue oxygenation.. Time is of the essence when dealing on this level.. Be aware and move on it please. Better safe than sorry. White blood cells must get into interstitial tissue to fight this internal war. These are All great info for all to know. Systematic vascular resistance with this particular situation and more.
Just brilliant preview and explanation .
you should add that Many Metastatic cancer Cells in the blood stream could cause a fast sever SEPSIS , and eventually death !
it usually happens at the advanced stages of cancer or with some aggressive cancers like Pancreas CA or , Biliary CA.
I had 2 prostate surgeries 4 months ago followed by Septic Shock 8 days later. One day my wife found me on the kitchen floor. The surgeries were a Sunday picnic compared to Septic Shock. It was a hell I hope I never see again. I still measure my blood oxygen and pulse per minute, and blood pressure 3 times a day. I consider myself a pretty tough guy but I still cry every day and I cant control it. I cried in the hospital several times a day every day. A nurse would walk in and say Good Morning and I would cry.
I hear ya!!! I'm crying reading this. I too had sepsis & sepsis shock & had a knee joint operation & 2 months later this crazy shit. My temp was 108. I am actually afraid of death now after reading & watching sepsis videos. I hope I never get this disease from hell again. Do you have cancer?
Metabolic Theory of Septic Shock
Please do a search for the above
Core tip: For decades septic shock has been attributed to an over-active immune response. However, immune modulation has failed to reduce mortality, casting doubt on a direct causal role for the immune response in the development of septic shock. A closer look suggests that septic shock is the result of a generalized build-up of hydrogen peroxide, a toxic cellular by-product generated as a consequence of the hypermetabolic state that accompanies a systemic immune response. This finding points to the systemic accumulation of hydrogen peroxide as a significant risk factor for the development of septic and non-septic shock syndromes.
+ale i think he meant nitrous oxide as just ONE of the many factors or molecules being released. I'm pretty sure what you mentioned will also be a factor considering the worsening condition of a patient. :)
eventually cells are gonna die, the lactic acid produced from aneurobic glikolysis (cells cant oxygenate) is going to pour to the blood. Thus you can see lactic acid in the blood both due to this mechanism and less cleaning of the substance
ice Devil Decreased tissue perfusion is something that happens in all types of shock. If there is less tissue perfusion, the tissues have less oxygen, so they have to turn to anaerobic metabolism, which creates lactic acid as a byproduct.
Thanks a lot, I personally searched this in books and couldn't understand it as well as i did here. I was afraid probably of the "unaccuracy" of the terms, but for real all was very precise and helpful. Again, thanks a lot.
I'm confused. So normally the infected material is in the tissues so the white blood cells need to move from the blood vessels into the tissue by making the blood vessel leaky. But now that the infection is the blood vessel how will that cause leakiness elsewhere? Is it because of the toxins released by the white blood cells also make it leaky?
+Alaina Lo When the infection is localized to a tissue then specific cells inside the tissue can secrete cytokines that "call" the WBC's to that area. When the WBC's get to that area they bind to selectins in the endothelial membrane and "roll" into the tissues. So it is quite a bit more coordinated than the widespread infection. When the infection gets into your blood, it goes EVERYWHERE. That is why your body responds with vasodilation EVERYWHERE and not just localized. Does that makes sense?
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