Tramadol is a common analgesic that provides its effects by acting as an opioid and serotonin-norepinephrine reuptake inhibitor (SNRI). The opioid portion of its effects mainly comes from a metabolite, O-Desmethlytramadol (O-DSMT), while tramadol itself has a greater impact on monoaminergic systems.
Both the opioid and SNRI effects yield pain relief and mood changes.
It does have recreational effects, perhaps more so in those who are efficient at metabolizing tramadol to O-DSMT, but it's generally viewed as less intense than an opioid like morphine or diamorphine (heroin).
Other names = Ultracet; Ultram
TDC page with more information and references: https://thedrugclassroom.com/video/tramadol/
Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/9hzwpu/tramadol_what_you_need_to_know/?
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Special thanks to BronzeManul for help with the chemistry section.
Medical effects: 00:38
Nonmedical effects: 05:22
Pharmacology and Chemistry: 12:23
How It's Used: 19:51
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Please keep up the science heavy material! Your channel is a huge source for helping my future pharmacy career.
You provide me a solid basis for selection of drugs giving patients the best quality of life possible. The info described for side effects is very accurate and well researched. I research much more in depth but the base info provided helps so much in deciding what may be the best choice for a patient.
Also your recreational use segments help even more. The medical field seems to ignore that people don't t follow directions 100% of the time. I know people will use the drug willingly or accidentally use more than the recommended dose. Your channel helps me better understand patients and allows me to adapt to their needs.
Keep up this amazing work! You're a huge influence in my education and I am forever grateful that your channel exists
i have so much respect for you and what you're doing, man. The way you responded to my political nag on one of your videos recently just showed how you have CLASS (as in you won't just flame some random nerd because they didn't check the date on your videos) and it serves to, dare I say, PROVE, that you're willing to learn and accept new information all while being polite, earnest and respectful. A genuine, well-intentioned and nice human. Easily the most important traits a content creator could have in this field, by a country mile. Especially when you get into things in the community like elitism and stereotypical peer-pressuring to dose higher. As a 7 year opioid addict and decade-long drug-enthusiest, I can say I recommend your videos _so_ often when people ask me questions about drugs and drug combinations that it's kinda insane. And while I promote harm reduction, self-awareness and restraint because I don't want anyone else to go down the path of opioid dependance that I did, even if I don't think it's something that should influence the way you view someone who you may have found out to be an opioid user. We're just like everyone else! It's just our u-Opioid receptors need a lil more lovin'! If ANYONE ever needs any info on specifically opioid harm reduction and practice, from a 1st hand perspective, feel free to hit me up any time! I wish I had someone with knowledge like our boy Seth when I started my psychoactive journey. And SETH if you ever wanna talk to the archetypal, stereotypical face of the US Opipid "Epidemic", holla at me! I have been through it all - rehab, inpatient, outpatient, halfway houses, methadone maintenance, suboxone, relapse, all of it. Sorry for the rant - been using adderall to be able to get through my 10 hour shifts at work without wanting to end my own life haha
Been taking Tramadol 50mg 2 times a day everyday for 1.5 years and feel every positive effect from it and not have the need to increase the dose, but my body is of couse dependent on it now and I do get withdrawls if I stop taking it so be careful..
Tramadol fuckin kicks ass! I love the stuff, I take it every day for years & years & have had no problems with it whatsoever. Mood enhancing & great euphoria with VERY slow tolerance rising to it make it a #2 choice in ALL the medicines I have taken daily in the past.
I only feel positive effects, I feel every single positive effect mentioned in the video. Been taking 50mg 2 times a day every day for 1.5 years without having the need to increase dose, the drug truely do wonders for me. I do take 100mg every saturday and sunday morning tho and smoke some weed then go back to bed and cuddle with my cat for couple of hours, most amazing feeling ever. The withdrawls is real tho if I stop taking it.
PS: great video as always, you re actually doing a good job when it comes to drug education and harm reduction which are really important and serious topics
im sure the other viewers appreciate that just as much as i do
+LyesergicBrainwave ahh never tried benadrill. Well a friend of Mine once took 900mg at once and had the most amazing feeling, and my second friend always take 600mg+ at once but rarely take tramadol so I thought 500mg isnt that bad, I was wrong hahah, we all react different to drugs and doses. Yeah i've done lsd as I said before, my first time I tried lsd I took 200ug alone, and I was totally mindblown. It really change the way you look at life, I was kinda sad the next couple of days tho since I couldnt explain the amazing things I saw to anyone.
no I take benadrill before bed, I ride the tram 3 sometimes 4 times a day; 200mg each time. Yea 500mg; you were just testin the waters though I take it? see what's what? getting yer feet wet to feel the big splash? By any chance have you ever done LSD before? that is the most amazing drug there ever was, that shit is SO awesome of an experience.
+LyesergicBrainwave thats amazing that your tolerance only has doubled after 13years :o Do you take tramadol before bed too? Yeah dont take 500mg at once like I did, you litterally cant focus or think, you just sit there feeling dumb as fuck hahah.
yea I was doin about 400mg a day when I 1st started but over the coarse of about 13 years; all my tolerance has done is doubled once. But when I 1st started the pills were 50mg each & now the pills are 100mg each & I always take 2 at a time 3 or 4 times a day. The most I have ever done at 1 time is 200mg
- when there's a lot of text on the screen, the top text gets cut off
- u should talk a little faster imo, i put u at 1.25x speed and thats better for me
- keep a sections header at the top with annotations so we can follow along in the vid where we r and what is coming next and click to jump to any section in the video. i think this would be more useful and would replace the intro slide with all the sections and timestamps listed without any annotations
hope u find this useful
William Schutz well the uploader is retarded too then by your logic for being the 1 that said that. I guess im retarded for relaying information someone said to someone (yea that makes a whole lot of sense) lol my sister is my mom huh? I can see that someone is a complete dumbfuck because if you think about that for 2 seconds you realize that that's not even possible because your sister can only come out of your mom & therefore cant be her. It's only a shitty excuse for a drug for those with clumsy, dopy, weak brained people who's brains wouldn't notice something like tramadol. Its clearly too good for a good number of people & my god that makes me feel a lot better about myself knowing that my brain can actually register how awesome tramadol is. Not sorry your a weak underling...
LyesergicBrainwave You are RETARDED. You do not have any tolerance towards strong opoids that is why this shitty excuse for a drug is working for you. Your DNA is completely fucked, your sister is your mom for fucks sake.
Extremely effective painkiller but it is addictive and there is a high risk of delirium in groups such as the elderly and those with learning disabilities. It's really important to carefully consider the risks and benefits (just like with any prescription). Great vid, nice to see you posting more. Check out my Drugs and Mental Health playlist on my channel Mental Health with Dr Elliott :)
Interesting to know that my lack of response may have been genetic. I have taken it therapeutically and on occasion recreational, it seemed to work best in the former. I have many friends (admittedly opiate addicts) that use Tramadol often... By observing their behavior, they seem to exhibit behaviors similar to heroin abuse. I don't recall if you mentioned it but I have known SEVERAL people who have reported seizure on Tramadol, one of which I witnessed... (although I cannot rule out poly drug use). Again Thank You for another great video!!!!
So earlier this year I was involved in an extreme car accident, I broke my back along with collarbone and internal bleeding. I was IVed Dilaudid and given oral oxycodone and tramadol afterward. I had to take both several times a day to feel less pain, not feel no pain. I still get chronic back pain and so my doctor prescribed me 90x 50mg tramadol. I also went through neuropsychoanalysis at a neuropsychology office me and found that my concussion went back to baseline along with underlying anxiety and depression.
Here's where I'm getting with this, knowing now that an effect of tram is to take away and depress those underlying negative feelings would be a major reason that I love it so much. I take it 3-4 days a week due to back pain and it has been very difficult to go throughout a day sober, whether that means kratom, oxy, tramadol, or even things such as amphetamines when I have to do a lot of college school work. I hate it so much but it is so difficult to stop being a poly drug addict. I really wish that my doctor could have helped me more with my pain or found some other path than tramadol when he was the one who suggested the nueropsychology appointment and was one of the first doctors to get the results back.
I appreciate this information you're able to gather and give to us in such a well-made vehicle. I hope to get sober soon but for me right now that would mea a break from everything incuding school. My winter break I'm getting surgery again to remove my metal plate in my collarbone so it will be even more difficult to stop opiates. I really hate what has happened to me and how I react to it and blame it more rather than myself.
Thanks a trillion for repost / update - presently taking t.dol until my Rx deductible resets.
TDC is such a super resource; even if yr science sections make me billion times more informed than my md or harmacist types.
After 1 month of Tramadol, i had SEVERE Restless Leg Syndrome when i tried to sleep. Took about 3 weeks of sleepness nights to get back to my old self..
In my experience, theres no reason for Tramadol unless the patient is allergic to opiates like Vicodin. Atleast Vicodin is a semi-synthetic, Tramadol is a completely man made chemical.
Tramadol is less potent than vicodin but the nausea and risk of delirium can still be really problematic. It's a really good painkiller though so it's finding the right balance to make sure it's prescribed appropriately.
that’s wds unless you were still taking it then it’s just the side affect of the drug, most people get prescribed tramadol when they start the pain management and the patient doesn’t want to use more addictive prescriptions. i agree useless to most and the risk of seizures isn’t worth even filling the script
Very good information about Tramadol. Personally prefer it to subuxone/subutex when treating OUD. It's good if the person using is still in the pill stages and hasn't started with heroin even then they may need subs. However many people say that after having had subs and failed and also trying tramadol they did think the tramadol was easier to get off of but complained it took a long time to kick in and didn't cover all the symptoms of withdrawal but most of the worst ones.
I've never met anyone that abused Tramadol before I met my sister in law. She would take up to twenty in one day before we kept her in check and me along with my wife had to step in and keep her doses within a reasonable range. The day she ate thirty one time and we were surprised that she didn't die that day. Got her down to 3 every two days within a short period, and she is now off completely. She was nodding out on my couch and would get defensive when we'd wake her up. The day we stepped in was when she spilled her medication all over my couch and I was the only one who notice. She had been using it for years and had gotten really bad the past year. Now she's sober aside from her mj card, that I felt she should transition to. Psychedelics helped me get completely sober myself. Stay positive people and help your friends!
I have been prescribed tramadol for a chronic pain condition the last 4 years. I used to get a small buzz of euphoria when taking 100 mg rapid release - but that was years ago. I take a delayed release 100 mg capsule every 12 hours and it takes the edge of the pains - but increasing dosage is not more effective. If I stop taking them I get brain noise - like electric jolts through my head and I feel cold and get goosebumps. So yes it can be addictive.It has very little value as a recreational drug and I do not recommend taking more than 400 mg daily
Great video! You should really post more often! I've been prescribed Tramadol and Lyrica for several years already but I was rarely taking it in order to avoid dependence. I am also prescribed Concerta which is fairly expensive and often in shortage here.
+William Schutz God you are more retarded than I thought. Just because the video was uploaded in 2017 DOES NOT mean it's from that year you fuck. That was when I was in high school in 2007. It was on a 16 bit camera tapes, you know those little small tapes. I had them transferred to DVD thru Walmart. Then I played the DVD on my laptop & recorded it on my iPhone. That's why the quality is so bad. You want me to post a current video of me naked just for you? God you're stupid, couldn't of even used you thinking skills to even guess how a video could not be current, but yet again I'm not surprised by your lack of intelligence. Good job! You must take everything on the internet at face value you wigger fuck.
OnlineDater69 Your "smoking at the mall" was dated from last year! Stop with the lies. Also the amount of grammatical errors in your comments are astounding!!! Christ almighty man you are one stupid fucker!!!
+Ethan Watson You know your statement isn't actually what you think it is. You should research your statements first...retard. You're not a doctor. I know what you are trying to imply but you don't actually understand what you are trying to convey. I'm sure you understand synthetic vs. natural. Let me guess you've read that on Facebook. Lol
JuaffreBlumpkins Have you considered the clinic? Best advice I can give you is when you feel that you can never stop but you are ready to kick the habbit for good and are focused on it then try the methadone clinic. Saved my life and I only go 4 times a month and it's free in Baltimore. But only join if there are no other options. It's a very long lasting drug and the withdrawls make dope feel like childs play. Good luck buddy!👍
+Brian Armstrong you didn't take anything to help with the withdrawals?
Are you using other opioids now?
When I tapper off of tramadol I only take 50mg in the morning so my body at least doesn't act bat shit crazy through out the day, then I would end the day with a 250mg soma for the insomnia. You build a quick tolerance to somas which sucks.
CBD and klonopin helped with anxiety for the first week too.
+William Schutz the temptation is unreal when you have people around you who use or used IV methods.
I've been trying to get clean and it feels like I'm climbing a ladder but constantly slipping. I've already OD once in 2016 and almost OD again last week.
The guilt is what kills me after every time I use. I just know I'll either end up over dosing or just end up dead if I start banging.
Life is a bitch, lol
Coming off tramadol id cold sweats, fever, vomiting, night terrors, sleep paralysis, crying like a child because my brain was on fire. I had this crazy anxiety also. I was worrying about stuff and getting upset about things that i would rationalise as no big deal today. Its different for each person, but i'd the worst 2 weeks of my life coming off this. Be careful with how much and how long you take this.
A local hospital was giving liver transplant patients tramadol, and they had to stop
the prescribing practice because of the high frequency of seizures in the patients. Seizures are a common reaction to liver transplants.
Giving a patient who's predisposed to seizures tramadol for legal reasons will more likely harm than hurt the patient. Is that really better than prescribing oxycodone instead?
Gui Kirsch i can totally see seizures being a huge side effect. Gave me RLS, Depression, Anxiety. Fuck Tramadol. Just take hydro, oxy, or codiene or dont fuck with opioids at all. Fully synthetic medications have fucked up side effects
Great Video. It would be cool if someone could answer my question here: I don't really get the supposed "euphoric" or "warm opiate blanket kind of feeling". It just killed the pain i had after an operation. (Took it for about 6 days) No "high" feeling whatsoever. Even after going up to 80mg (talking about pharmaceutical Oxycodon from my doc) then i tried tramadol. (Not quite so legal) Same thing. How? Why? Would love to know what exactly is going on in my Body there.
Varies from person to person which often comes down to how efficiently it is metabolised. In general the faster it gets into the blood and the quicker and higher the peak in concentration of a psychoactive drug, the more likely you are to get euphoria or similar symptoms but also the more addictive the drug.
The interaction should mostly be at the level of side effects, like increased sedation and impairment. It's not usually considered a dangerous combination, but whether it'll work well is going to vary between people.
Those are high on my list of things to discuss, although I must admit *a lot* of things are on that list. I'm working on ways to try and release content faster, so hopefully it won't be too long before those are covered.
+Arthur Porter Hey there. No offense taken but thank you anyway for not being the other type of guy we often see. I was on 150mg daily of Tramadol for years due to chronic pain ... there were times when I took 150mg XR x2 daily. And one day out of the blue, it stopped working. Just like that. My new GP didn't wean me off because I was taking Cymbalta as well ... the two drugs show major contra-indications. I went into full hellish withdrawal for weeks on end ... drug craving, heightened depression, anxiety to name a few ... I will never forgive him for putting me through this. From my perspective, Drs aren't fully aware of the dangers and addiction potential. I later did some research and only found one study (if it can be called that) relating to a lady in the US or UK entering an emergency facily in full-blown withrawal aka Drug Discontinuation Syndrome. I would cite the source if I could remember it, but I can't. Perhaps search Tramadol + DDSyndrome. As I said, I only found one article unfortunately. Tramadol is a good drug for moderate-severe pain if used sparingly IMHO. The other problem relates to misuse. I understand that misuse is currently problematical in India. But anyway, that (in brief) was my experience of this drug. Maybe one day I'll use it again ... maybe. Thank you for responding! ✌☺
Certainly. My focus has been on psychoactive medications and recreational drugs, but TDC won't be restricted to those. Hormone-affecting substances and nootropics, among others, will eventually be discussed.
+The Drug Classroom fantastic! It's great to see a chanel that doesn't glorify or endorse substances but instead just puts out the facts and keeps them up to date and comprehensive. You are doing us all a service, thank you :)
+The Drug Classroom
i find after 20+ years of daily usage of prescribed Tramadol 400mg per day , that it is a miracle drug , that effects the body in so many positive ways at once compared to other opiates or mild antidepressants .
But the positive benefits of pain release, mood improvement, numbing of penis , energy boast , all disappear over several months of usage . unless i up the dosage to over seizure levels . "2000mg in one go"
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.