Tramadol is a common analgesic that provides its effects by acting as an opioid and serotonin-norepinephrine reuptake inhibitor (SNRI). The opioid portion of its effects mainly comes from a metabolite, O-Desmethlytramadol (O-DSMT), while tramadol itself has a greater impact on monoaminergic systems.
Both the opioid and SNRI effects yield pain relief and mood changes.
It does have recreational effects, perhaps more so in those who are efficient at metabolizing tramadol to O-DSMT, but it's generally viewed as less intense than an opioid like morphine or diamorphine (heroin).
Other names = Ultracet; Ultram
TDC page with more information and references: https://thedrugclassroom.com/video/tramadol/
Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/9hzwpu/tramadol_what_you_need_to_know/?
Donate to The Drug Classroom:
Special thanks to BronzeManul for help with the chemistry section.
Medical effects: 00:38
Nonmedical effects: 05:22
Pharmacology and Chemistry: 12:23
How It's Used: 19:51
Thank you to my Patreon supporters: RollSafe.org, Gui Kirsch, michael hoogwater, Alexander Pavlenko, Sam A., Reece hosford, Jarrod o'connell, Daniel X Moore, Christoffer Finstad, Zachary Thomas Binkley, Dane Overman, Dragonhax, Jacob Fournier-Paradis, Ben Shipp, Brian Henry, Adrian Selnes, Victor Stasek, Marty Sederberg, Kate Crilly, Ikaros, and Chandler Ledbetter.
Facebook - http://facebook.com/thedrugclassroom
Twitter - http://twitter.com/drugclassroom
Email - firstname.lastname@example.org
The Drug Classroom (TDC) is dedicated to providing the type of drug education everyone should have. Drugs are never going to leave our society and there has never been a society free from drugs.
Therefore, it only makes sense to provide real education free from propaganda.
TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring.
Feel free to ask questions!
I believe TDC could be a useful source of drug education, especially as more types of content are added, such as shorter and less science-heavy videos. I'm grateful for all of the support TDC has received from people who also feel this resource has a lot of potential. It means a lot to know there are people who view TDC the same way I do.
Support from listeners remains the only funding source for the project, so if you want to help out and ensure TDC is able to grow, donations are the best way to help. You can donate via Patreon, PayPal, and Bitcoin. Details on how to do so are available here: https://thedrugclassroom.com/support/
Please keep up the science heavy material! Your channel is a huge source for helping my future pharmacy career.
You provide me a solid basis for selection of drugs giving patients the best quality of life possible. The info described for side effects is very accurate and well researched. I research much more in depth but the base info provided helps so much in deciding what may be the best choice for a patient.
Also your recreational use segments help even more. The medical field seems to ignore that people don't t follow directions 100% of the time. I know people will use the drug willingly or accidentally use more than the recommended dose. Your channel helps me better understand patients and allows me to adapt to their needs.
Keep up this amazing work! You're a huge influence in my education and I am forever grateful that your channel exists
I tried Tramadol many times before. Only when I were at a really low point in my life the effect was completely diffrent and the euphoria was insane. I became addicted for 8 months detoxed and never did it again. Be careful. Some people's bodys are just waiting for an Opioid
100mg on tram is enough for me to have 12 hours of floatiness throughout the day, i absolutely love it for stressful days at work. Ive been using it for a couple of years making sure to only use it twice a week max. No negative effects from me, i guess im just lucky that im susceptible to it at such a small dose. I smoke cannabis daily and it mixes well with the tramadol. Love it
I’ve been on the same dose since 2006 to control my chronic pain from Lyme disease. It definitely doesn’t work as well as it used to ( but that’s how tolerance works) but it allows me to function. But the withdrawals are hellish. Honestly, they’re worse than any withdrawal I’d experienced from Norco.
pls do one on vyvanse! specifically the pro-drug aspect and how it affects metabolism, absorption, etc. because I'm also on Zyprexa and it completely cancels out Adderall but it just lessens my Vyvanse a little bit.
I used Tramadol for some 15 years. Normally only 50mg a day. It affected me in almost all the positive ways the video notes. Mood, energy, etc. etc. Then this big opioid scare came up and OH NO I can't have it any more. That was 3 years ago and I still wish I could take it. No withdrawal at all. It is NOT a true opioid, and does not affect you the same way as a true opiod! I know because I've had true opioids prescribed for pain.
galanie I totally understand. I’ve also been on it for 15 years and my doctor is cutting my dose down bc of the “opioid epidemic “. It’s not fair bc this medicine allows me to have my life back. I have bad damage to my spinal cord from my chronic Lyme disease along with bad musculoskeletal pain. I’m glad to hear you had no withdrawals. Unfortunately for me they are horrific.
I tried tramadol nasally, I crushed it up into a fine powder and sniffed it, and let me promise you, the head pressure and headache comes right on. Wanna have the worst headache of your life, sniff some tramadol. (not recommended).
Great video!! I was wondering if you could do a video on CBD, I think it'll help educate the public on how it works and it's history as I've seen it being used to help; anxiety, depression, ADHD, preventing schizophrenia, and more. Cheers and keep up the good work.
I love this channel so much. These are the kinds of lessons schools need to be teaching about drugs, not the typical biased bullshit that's been outdated for years now. I feel like if it wasn't for this channel, I would've made mistakes with my drug experiments that could've ended up costing me my life, im thankful that I researched before trying something dangerous .
i have so much respect for you and what you're doing, man. The way you responded to my political nag on one of your videos recently just showed how you have CLASS (as in you won't just flame some random nerd because they didn't check the date on your videos) and it serves to, dare I say, PROVE, that you're willing to learn and accept new information all while being polite, earnest and respectful. A genuine, well-intentioned and nice human. Easily the most important traits a content creator could have in this field, by a country mile. Especially when you get into things in the community like elitism and stereotypical peer-pressuring to dose higher. As a 7 year opioid addict and decade-long drug-enthusiest, I can say I recommend your videos _so_ often when people ask me questions about drugs and drug combinations that it's kinda insane. And while I promote harm reduction, self-awareness and restraint because I don't want anyone else to go down the path of opioid dependance that I did, even if I don't think it's something that should influence the way you view someone who you may have found out to be an opioid user. We're just like everyone else! It's just our u-Opioid receptors need a lil more lovin'! If ANYONE ever needs any info on specifically opioid harm reduction and practice, from a 1st hand perspective, feel free to hit me up any time! I wish I had someone with knowledge like our boy Seth when I started my psychoactive journey. And SETH if you ever wanna talk to the archetypal, stereotypical face of the US Opipid "Epidemic", holla at me! I have been through it all - rehab, inpatient, outpatient, halfway houses, methadone maintenance, suboxone, relapse, all of it. Sorry for the rant - been using adderall to be able to get through my 10 hour shifts at work without wanting to end my own life haha
Been taking Tramadol 50mg 2 times a day everyday for 1.5 years and feel every positive effect from it and not have the need to increase the dose, but my body is of couse dependent on it now and I do get withdrawls if I stop taking it so be careful..
Tramadol fuckin kicks ass! I love the stuff, I take it every day for years & years & have had no problems with it whatsoever. Mood enhancing & great euphoria with VERY slow tolerance rising to it make it a #2 choice in ALL the medicines I have taken daily in the past.
I only feel positive effects, I feel every single positive effect mentioned in the video. Been taking 50mg 2 times a day every day for 1.5 years without having the need to increase dose, the drug truely do wonders for me. I do take 100mg every saturday and sunday morning tho and smoke some weed then go back to bed and cuddle with my cat for couple of hours, most amazing feeling ever. The withdrawls is real tho if I stop taking it.
PS: great video as always, you re actually doing a good job when it comes to drug education and harm reduction which are really important and serious topics
im sure the other viewers appreciate that just as much as i do
+LyesergicBrainwave ahh never tried benadrill. Well a friend of Mine once took 900mg at once and had the most amazing feeling, and my second friend always take 600mg+ at once but rarely take tramadol so I thought 500mg isnt that bad, I was wrong hahah, we all react different to drugs and doses. Yeah i've done lsd as I said before, my first time I tried lsd I took 200ug alone, and I was totally mindblown. It really change the way you look at life, I was kinda sad the next couple of days tho since I couldnt explain the amazing things I saw to anyone.
no I take benadrill before bed, I ride the tram 3 sometimes 4 times a day; 200mg each time. Yea 500mg; you were just testin the waters though I take it? see what's what? getting yer feet wet to feel the big splash? By any chance have you ever done LSD before? that is the most amazing drug there ever was, that shit is SO awesome of an experience.
+LyesergicBrainwave thats amazing that your tolerance only has doubled after 13years :o Do you take tramadol before bed too? Yeah dont take 500mg at once like I did, you litterally cant focus or think, you just sit there feeling dumb as fuck hahah.
yea I was doin about 400mg a day when I 1st started but over the coarse of about 13 years; all my tolerance has done is doubled once. But when I 1st started the pills were 50mg each & now the pills are 100mg each & I always take 2 at a time 3 or 4 times a day. The most I have ever done at 1 time is 200mg
- when there's a lot of text on the screen, the top text gets cut off
- u should talk a little faster imo, i put u at 1.25x speed and thats better for me
- keep a sections header at the top with annotations so we can follow along in the vid where we r and what is coming next and click to jump to any section in the video. i think this would be more useful and would replace the intro slide with all the sections and timestamps listed without any annotations
hope u find this useful
William Schutz well the uploader is retarded too then by your logic for being the 1 that said that. I guess im retarded for relaying information someone said to someone (yea that makes a whole lot of sense) lol my sister is my mom huh? I can see that someone is a complete dumbfuck because if you think about that for 2 seconds you realize that that's not even possible because your sister can only come out of your mom & therefore cant be her. It's only a shitty excuse for a drug for those with clumsy, dopy, weak brained people who's brains wouldn't notice something like tramadol. Its clearly too good for a good number of people & my god that makes me feel a lot better about myself knowing that my brain can actually register how awesome tramadol is. Not sorry your a weak underling...
Avery Daymond MAGA Honestly I have to agree. I was wondering why when I took some last time I was drinking coffee and it felt like I'd taken more than I did. It lasted all day and was very relaxing. Listen up people, this is true according to my experience.
Extremely effective painkiller but it is addictive and there is a high risk of delirium in groups such as the elderly and those with learning disabilities. It's really important to carefully consider the risks and benefits (just like with any prescription). Great vid, nice to see you posting more. Check out my Drugs and Mental Health playlist on my channel Mental Health with Dr Elliott :)
Interesting to know that my lack of response may have been genetic. I have taken it therapeutically and on occasion recreational, it seemed to work best in the former. I have many friends (admittedly opiate addicts) that use Tramadol often... By observing their behavior, they seem to exhibit behaviors similar to heroin abuse. I don't recall if you mentioned it but I have known SEVERAL people who have reported seizure on Tramadol, one of which I witnessed... (although I cannot rule out poly drug use). Again Thank You for another great video!!!!
Thanks a trillion for repost / update - presently taking t.dol until my Rx deductible resets.
TDC is such a super resource; even if yr science sections make me billion times more informed than my md or harmacist types.
+CARLOS VASCONCELOS i believe i might have done so but only one pill im not sure i forget but i think i could have popped the little handful i had, if i did its cuz i asked if u were able to n they told me should be able to but that was few years back
After 1 month of Tramadol, i had SEVERE Restless Leg Syndrome when i tried to sleep. Took about 3 weeks of sleepness nights to get back to my old self..
In my experience, theres no reason for Tramadol unless the patient is allergic to opiates like Vicodin. Atleast Vicodin is a semi-synthetic, Tramadol is a completely man made chemical.
Tramadol is less potent than vicodin but the nausea and risk of delirium can still be really problematic. It's a really good painkiller though so it's finding the right balance to make sure it's prescribed appropriately.
that’s wds unless you were still taking it then it’s just the side affect of the drug, most people get prescribed tramadol when they start the pain management and the patient doesn’t want to use more addictive prescriptions. i agree useless to most and the risk of seizures isn’t worth even filling the script
Very good information about Tramadol. Personally prefer it to subuxone/subutex when treating OUD. It's good if the person using is still in the pill stages and hasn't started with heroin even then they may need subs. However many people say that after having had subs and failed and also trying tramadol they did think the tramadol was easier to get off of but complained it took a long time to kick in and didn't cover all the symptoms of withdrawal but most of the worst ones.
I've never met anyone that abused Tramadol before I met my sister in law. She would take up to twenty in one day before we kept her in check and me along with my wife had to step in and keep her doses within a reasonable range. The day she ate thirty one time and we were surprised that she didn't die that day. Got her down to 3 every two days within a short period, and she is now off completely. She was nodding out on my couch and would get defensive when we'd wake her up. The day we stepped in was when she spilled her medication all over my couch and I was the only one who notice. She had been using it for years and had gotten really bad the past year. Now she's sober aside from her mj card, that I felt she should transition to. Psychedelics helped me get completely sober myself. Stay positive people and help your friends!
I have been prescribed tramadol for a chronic pain condition the last 4 years. I used to get a small buzz of euphoria when taking 100 mg rapid release - but that was years ago. I take a delayed release 100 mg capsule every 12 hours and it takes the edge of the pains - but increasing dosage is not more effective. If I stop taking them I get brain noise - like electric jolts through my head and I feel cold and get goosebumps. So yes it can be addictive.It has very little value as a recreational drug and I do not recommend taking more than 400 mg daily
+Brandon Lester yes sound very similar. Tramodol actually works a bit like a SNRI anti-depressant too so the withdrawal side effects are similar too. Methadone is a very strong opioid that can be used as a painkiller or as substitution treatment for opioid addiction - I once took a dosage recreationally and I overdosed since I did not know the strength of the liquid form of methadone. I nearly stopped breathing and it was a scary experience. Take care
Niller, im on methadone and an SSRI called citalopram. When i stop taking my SSRI, i get those electric jolts, and the opiate withdrawls always start with the chills.
Sounds like your in the same boat i am. Probably less intensively though.
Great video! You should really post more often! I've been prescribed Tramadol and Lyrica for several years already but I was rarely taking it in order to avoid dependence. I am also prescribed Concerta which is fairly expensive and often in shortage here.
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.