this is crazy good and useful! I finally understand what all these alpha and beta things are in my pharm class. Thank you so so much!! Your video is simple, straight to the point and easy to follow and understand compared to all the other ones out there.
Edit Dec 24, 2018 .. Edit these later.
1:25 Phentolamine, phenoxybenzamine for hypertension caused by Pheochromocytoma (tumor that secretes norepinephrine, epinephrine. Acts on A2 receptors to inhibit its own release so blockade of these receptors result in more no-rep release. Norep stimulates --> B1 receptors on heart ... that's why non-select P,P can cause Tachycardia and cardiac arrhythmia.
Phenoxybenzamine is an irreversible antagonist and only way body can overcome it is if body makes new adrenergic receptors which takes about 24 h.
Phentolamine is reversible antagonist (lasts 4h
2:50 Selective block A1 receptors located mainly in vascular smooth muscle which reduces peripheral resistance and leads to decreased BP and also relaxes smooth muscles in the bladder neck --> USED for BPH (enlarged Prostate)
3:28 Think "zoesin"
3:40 Prazosin PDT
Doxazosin hypertentsioin ( little effect on BPH
Alfuzosin BPH (little effect on BP) because these targets A1 in prostate
5:18 A & B are both has selective and non-selective
5:30 Beta blockers are competitive inhibitors at beta adrenergic receptors and they counter effects of catecholamines (Epinephrine, Nor Ep) ( which is why this is useful in treatment of hypertension, HF, H attack, angina, cardiac arrhthmias, also treatment of glaucoma and migraine prophylaxis
6:20 1st gen PIC. Propranolol, Pindolol, Nadolol, Sotalol, Timolol.
acts on B1 receptors on heart --> HR down , delayed conduction through AV node and Contractility down so the final outcome is less Cardiac otuput and decreased oxygen demand on the heart muscle
6:49 Propranolol can penetrate to CNS ,, can be used for migraine prophylaxis
7:00 Timolol eye = reduces intraocular pressure
7:17 B2 receptors in lungs (*these being blocked --> bronnchoconstriction (DON'T if COPD, asthma
7:38 B blocker 2nd generation (targets B1 receptors) / cardioselective beta blockers
BEAMS atenolol , acebutolol , Bisoprolol , Esmolol , Metoprolol
8:20 3rd generation has selective and nonselective B blockers. Unlike gen 1 or 2 , these 3rd generation= act on blood vessels .
Non selective (B + A1 ) Carvedilol, Labetalol .
B1 selective = nebivolol vasodilation by releasising Nitric Oxide from endotehelial cells.
Betaxolol v .. by additionally blocking Calcium channels ( CCB)
.. also can be applied to eye ,glaucoma, .
9:50 Carvedilol and nebivolol have natioxidant properties (preferred for HF also alongside commonly prescribed with Bisoprolol and Metoprolol
10:07 Intrinsic sympathomimetic properties (Pindolol, Acebutolol .
Pindolol and Acebutolol not only block but also to weakly stimulate both Beta 1+2 receptors which leads to diminished effect on cardiac rate and output. These 2 are for pt who can't tolerate other Beta blockers because of pre existing bradycardia or heart block .
I had ed due to over use of pains enlargement device as pump. I had symptoms called in Internet hard flaccid. Which my cc contract. I go many doctors who help nothing they said psychological ed. I read hard flaccid hf is sns reaction which made my penile smooth muscle did not relax to full capacity. Can alpha blocker help me?
Because I had this chronic problem for 8 years
Please help me doctor....
Guys, here is a way to remember which drugs belong to what group between the 1st generation and 2nd generation drugs of the BETA Blockers. (Note: this method only works for the drugs mentioned in this video). So just remember the letter M, which is the letter that comes in the middle of the alphabet (there are 26 letters in the alphabet, it is the 13th letter). So any drug that starts with any letter from A through M (so any drug that begins with a letter in the first half of the alphabet) belongs in B1 selective antagonists and any letter that starts from N through Z (so any letter that starts with a letter in the second half of the alphabet) belongs in non-selective (1st generation) BETA blockers. Hope this helps...
I already subscribe coz I’m in my mid to late 60s w HBP for the past 15 plus yrs, it’s so easy to understand & learn what alpha & beta blockers are & how they function in treating HBP & for those w heart prob, something doctors don’t do or explain b4 they write a prescription, how can a patient know & understand what & how this med that was just prescribe, I guess all we have to do is get & take, which is & have been the norm unless we ask questions, so these videos are so informative & teach us what they’re suppose to do, ThankU so much for ur kindness & good hearted work the time & effort, may God bless you & yours, w good health & happiness, especially in 2018 & beyond, keep up the good work, ThankU & Happy 2018!!
it is not as easy to explain in few minutes during your visit/checkup. it is even hard for us student to understand so imagine a patient who doesnt know many of this stuff that were explained in 3 videos if almost 10min each. i appreciate your curiosity in learning how things works, but i dont think many people are willing to do the same
gil bkk .... Sometimes you need chemical crap, not everyone's blood pressure is controlled naturally... The silent killer takes lives all the time when blood pressure is not controlled... Also heart rhythm disturbances can kill people without these drugs ...
waaaoooh ! waaooooh ! thank you ! it's genious ...we need your vidéos and we hope that it will be in french ! pleeeeeeaaase I'm in love with your vidéos ! so please ... make them with french
for the sake of God
I want to ask something:
1.In previous video norephineprin mainly stimulate alpha 1 receptor which increase blood pressure and almost dont stimulate beta receptor. But here, norephineprin stimulate beta 1 receptor and not alpha 1 receptor?
2. In nonselective alpha blocker, alpha 1 & alpha 2 blocked. Alpha 2 blocker causes norephineprin release more, but why it doesnt have an effect to alpha 1 receptor that cause increase blood pressure. And moreover nonselective alpha blocker used for hipertention that needs low blood pressure.
I still get confused abt this, please answer me, thank you..
1. norephineprin stimulates alpha 1 as well as beta receptor but it has increased affinity to alpha 1, this does not mean that stimulates only alpha 1, it means stimulates alpha 1 more than the beta.
2.Alpha 2 blocker does not have direct effect on alpha 1 receptor, but due to norephineprin release it increases blood pressure beacause the beta 1 effects are taking place (reflex tachicardia).
i hope it helps you, have a nice day!
Thanks for this channel. I'm currently working on my pre-reqs to apply to pharmacy school. However, I wan't to try to learn as much pharmacology as I can to truly be prepared when I get accepted. Keep the videos coming, you have a new subscriber.
whoa! I can understand this. My professor seems to be talking in another language when discussing these but you've made it simple and easy to understand. Thank you very much and keep making great videos!
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.