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Topics covered include: anxiety, insomnia, role of GABA in the central nervous system, structure and function of GABA-A receptor, limbic system, mechanism of action and side effects of benzodiazepines, barbiturates, and non-benzodiazepine hypnotics. Drugs mentioned include; Alprazolam, Chlordiazepoxide, Clonazepam, Diazepam, Lorazepam, Temazepam, Pentobarbital, Phenobarbital, Secobarbital, Zolpidem, Zaleplon, and Eszopiclone.
The science of benzos is GABA receptor down regulation of the CNS, GI tract, brain, and muscles meaning that natural fight or flight responses are dulled causing people to experience more anxiety, increased panic attacks, more insomnia, increased PTSD symptoms, benzo rage episodes, suicidal ideation, digestive system problems, muscle issues, plus increased eating disorder thoughts and behaviors. The FDA states that physical and psychological dependence on a benzo is not the same as drug addiction. Dependence occurs within a few weeks to a benzodiazapine.
Dr.s do not advise patients of the real side effects. The Ashton Manual explains what benzos really do. Tolerance withdrawals occur when taking a benzo as prescribed but the patient experiences worsening panic attacks or other symptoms previously listed. Sadly patients are prescribed higher doses of a benzo when they are in tolerance withdrawals which only causes more issues with the CNS, GI tract, brain, and muscles.
Facebook has support groups for individuals who want to safely taper off of benzos.
Detox centers treat benzos as opioids. Opioids affect opioid receptors which take weeks to months to taper. Benzos can take months to years to taper. Withdrawal symptoms often happen even after completely off of the benzo for months to years.
Research which receptors each Rx drug affects for yourself.
Benzos should only be used for seizure disorders. Prescribing benzos for anything other than that is medical negligence.
A pharmacist of 25 years states that benzodiazapines can cause neurological damage that can be accidentally diagnosed as ALS, Parkinson's disease, multiple sclerosis, and Alzheimer's disease.
Great video on a really important topic. They're really useful drugs medically but the risk of dependency and addiction is not to be underestimate. The difference in mechanism behind benzos and barbiturates has profound implications on the risk of overdose too (hence why barbiturates are barely ever used nowadays). If you're interest in drugs and mental health then check out my channel Mental Health with Dr Elliott. Keep up the good work!
Anti epileptic drugs please... U will really make that topic easy and quick to revise I'm sure... Hope I'm able to see it before my final exams... Thanks for covering this topic as well.... U r awesome!!😍
Benzodiazepines are often used as a second line treatment of epilepsy, but i get what you mean. You have pregabolin, benzos etc. I'm on Clonazepam for anxiety and insomnia, but it is more widely used for epilepicts that do not respond to first line treatment.
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.