Wait, isn't the Thick ascending loop impermeable to H20? If we blocked the Na/K/CL co-transporter with a loop diuretic, we still shouldn't loose water in THIS area either in OR out, even if the sodium were to stay, right?
I think I get what you're saying here. The effect on loop diuretics in the thick ascending loop is to cause hyperosmolarity of the tubular fluid, but the effects of the water being driven into the this fluid DONT technically happen in this very area. That hyperosmotic tubular fluid that flows further ahead allows less water to be reabsorbed, in the principal cells perhaps? That the right idea here?
with loop you`re not stimulating the reabsorption of water in the thick ascending limb but blocking the reabsorption of salts,making it hyperosmotic(concentrated). The general rule then applies that water follows salt, which will appear in the following segments of the nephron.
Tq very much sir... But i have a doubt... At 12:21 (regarding cause of hyper calcemia) increase in sodium reabsorption at PCT must decrease calcium reabsorption....as both are positively charged ions...??
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.