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General overview of the RAAS system: Cells and hormones | NCLEX-RN | Khan Academy

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Learn the important cells and hormones that are working together to control your blood pressure! Rishi is a pediatric infectious disease physician and works at Khan Academy. Created by Rishi Desai. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-renal-system/rn-renal-regulation-of-blood/v/renin-production-in-the-kidneys?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-renal-system/rn-the-renal-system/v/secondary-active-transport-in-the-nephron?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
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Текстовые комментарии (99)
fachry ramadhan (2 месяца назад)
thank you it’s really helping me , i’m a medical student and now i’m on gastrourinary system topics 😃
Chris Jin (2 месяца назад)
Great explanation, but I think you missed out angiotensin-converting enzymes.
karin natasya (2 месяца назад)
Sreejith Chandrasekharan (3 месяца назад)
Thank you soooooooooooooo much!!
Alex Diaz (4 месяца назад)
I love the neighbor analogy! This was so helpful! Thank you for the great content!
greattvshows452 (4 месяца назад)
Great video ! What software is this ? It's awesome !
Fahamed Foisal (5 месяцев назад)
Really incredible....thankful to u
Marie Wang (7 месяцев назад)
Well explain
Medicman Dan (7 месяцев назад)
Great video and explanation, thank you!
Marshall McGough (8 месяцев назад)
what about ANP and BNP
Betty Ice (8 месяцев назад)
Why is angiotensin 1 face is awake, but his eyes is still closed?
stine eikeland (1 год назад)
Haha it woke me up! :D good video thanks
Suzy P (1 год назад)
Wow!! Very well explained. Thank you. Nice summary
Wendi Chiquirio (1 год назад)
that was awesome
Mrluckyjo (1 год назад)
nice voice, but i wish youtube had a 3x speed for this video. 2x speed is still waAAAAAAAAY too slow for me.
Bigdrop (1 год назад)
For everyone wondering about ACE (Angiotensin Converting Enzym), its on the surface of the Endothlial cells which he describes at 7:20. Or you can kinda say that ACE is released by Endothelial cells but they are still attatched to the walls of the vessels.
Charlana Boeggeman (1 год назад)
Excellent video and very thorough, but it's missing angiotensin converting enzyme! So important for us nursing students when considering the effects of ACE inhibitors.
Jenner (1 год назад)
where is your angiotensin converting enzyme ?
Bigdrop (1 год назад)
on the endothelial cell
lookingforsure (1 год назад)
amazing video thank you so much
Deanna M. (1 год назад)
great voice..video..and explanation...keep videos coming
NotoriousB3 (1 год назад)
This nigga forgot about ace
Kapparino (1 год назад)
What a goofy 😂 bruh they be out here 😜 talkin bout RAAS 🌡 and they be forgetting ACE 🔪 LMFAAAOOOOOO 😂😂😂😂😂😂
Rafael Morillo (1 год назад)
word B i knew something was missing
Lena Liu (1 год назад)
"CHOPS OFF A BIG HUNK! and if that doesn't wake you up, I don't know what will." Funny thing is that I was laying in bed, all comfy, my eyes closed, just about to drift off into dreamland, and that woke me the heck up thank you very much
tradesda liburd (8 месяцев назад)
i cracked up for this part
최미가 (1 год назад)
love the lectures
erik wennberg (1 год назад)
I'm a little confused about what actually induces renin secretion. Other than sympathetic innervation, you also mention a drop in blood pressure as well as a drop in Sodium concentration (in tubule fluid or in blood? Not necessarily the same thing). I have read that the decrease in blood pressure is actually detected by baroreceptors in the afferent arteriols in the kidney, not by the JG cells. Does anyone know? Also, I have read that the macula densa detects a decrease in sodium as you say, but also a decrease in blood perfusion to the kidney. Both of these factors will induce Renin-secretion. Does anyone know about this blood perfusion to the macula densa thing? Or is it just misinterpreted to the drop in blood pressure?
hamed bedar (1 год назад)
erik wennberg actually when the bp gets high initially the gfr increases causing more nacl to to be filtered so if the GFR is high fluid goes through tubules faster and there is less time for nacl to be reabsorbed from the PCT into the peritubular capillaries and when this high nacl reaches the macula dense it causes vasoconstriction of the afferent arterioles through vaso active substances thus decreasing GFR
Emily Wallace (1 год назад)
Not sure if this is right but surely if there was a decrease in blood perfusion it would cause a decrease in blood pressure? So the macula dense is picking up the decrease in blood perfusion and realising that there is a drop in blood pressure because of that. Could be wrong though.
Janean Reiniche (1 год назад)
Nursing student here, struggling in Pathophisiology and your videos are SO CRAZY HELPFUL!!! My peers love them too. Can't thank you enough!
Nadia Jamil (2 года назад)
Great videos! Keep making more!
Irving Perez (2 года назад)
WOW! This is an outstanding video. RAAS, easy peezy.
icebubbles44 (2 года назад)
Okay so that adrenal (add+renal) thing completely blew my mind. Great video, btw.
Carolyn Smith (1 год назад)
me too! I don't think I'll forget where it is ever again!
cihan K (2 года назад)
Thank you so much ❤️💐
MViOl (2 года назад)
The sympathetic nerve cells are from pelvic nerve?
saundarya fanda (2 года назад)
Awsm video.. Vry clear nd lucid explanation.. it's amazing.. thank u so much!!!!!!
rima sisca fanuela (2 года назад)
NICE! But what about ACE?
Melissa Lopez (2 года назад)
thank you sooo much! So easy now!
Philip Woe (1 год назад)
I know, wasn't that wonderful?
Rayan Vugdalic (2 года назад)
I find it strange that ACE was never mentioned in this vid (especially due to clinical significance), but still a great overview. Loving the khan academy medicine videos as introductions to topics/study motivators. Thank you 👍🏼
Stelios Lysiotis (2 года назад)
Could you explain me what makes the Sympathetic Nerve fire when the pressure drops? PRessoreceptors, or B-Receptors?
Maria Tækker (2 года назад)
+Stelios Lysiotis Baroreceptors. Chemoreceptors detect fall in O2, CO2 and pH.
mus x (2 года назад)
what about ace in the lung ?
Epi nephrine (2 года назад)
This system is very convoluted :(
Neha Rao (2 года назад)
It is very nice and easy to understand
Zahra Rajabalipour (2 года назад)
Great video, thanks! But what about ACE?
John Chaparro (1 месяц назад)
I did and he didn't mention ACE
omalginu (11 месяцев назад)
Did you even heard when he talked about the endothelial cells that are mostly related to the lungs?
Carla Carrazana (3 года назад)
you are the best! Thanks a lot! thanks Khan Academy!
manse mamanse (3 года назад)
could you please tell me ,so this Renin Angiostensin Aldosteron System is for activated renin angiostensin and aldosteron ,for example when that little guy ( renin ) knows that blood pressure is low ?so the renin have to activated for raise the blood pressure
Sarah Woon (3 года назад)
is it just me or the dude kinda sounds suuuuper high ... great video though ;)
Victoria Ann Phillips (9 месяцев назад)
it's just you
Madison Eckhart (3 года назад)
So so so so so helpful.
Mehul Sharma (3 года назад)
4:06 ... how does less BP lead to less movement of fluid ? does filtration rate increase or decrease ? how ?
A Nony Mouse (22 дня назад)
When there's less pressure, there's a less flow. Think of a faucet
Sarah Clifford (3 года назад)
Again excellently explained! You are officially my favourite youtube channel to watch!!!
Nazmulur Rahman nazmul (3 года назад)
could you please explain to me,how sympathetic nerves can increase renin secretion?could you please give me the link or reference for more clarification?
Azifah Ahmed (2 года назад)
+Ariel Smith love it
Ariel Smith (3 года назад)
+Nazmulur Rahman nazmul Sympathetic nerves innervate the afferent and efferent arterioles and receive signals from baroreceptors in the cardiovascular system (in the carotid sinus, aortic arch, etc) when extra cellular volume is low to secrete renin.
MandaA353 (3 года назад)
Donna Harris (3 года назад)
You are the BEST! You are helping me get through graduate school. You don't talk too fast, you break things down and make them fun, interesting and understandable. Also you have an amazingly great voice! Thank you so much for your videos
Liz W (3 года назад)
Excellent explanation.  Great videos, very clear, nice pace and use of graphics and voice.  Thank-you!
Yestay Rakhimov (4 года назад)
amazing)) thank you;)
Jessica Lafferty (4 года назад)
I really enjoy your videos, actually I think out of all khanacademy videos, yours are the best.  You really make a lot of sense of things and help consolidate the info in my head.  You really gave me a chuckle with your angiotensinogen face in this video.
Adam Hudson (4 года назад)
Not to be pedantic but my professor makes a point of saying renin is an enzyme, not a hormone.
Adam Hudson (4 года назад)
+Jessica Lafferty I think "enzyme" explains exactly what renin is: a protein that catalyses a chemical reaction.  I do see the point though, that since it is a chemical that has effects over long distances the term "hormone" is also appropriate.  I reckon my lecturer was just splitting hairs, it's just semantics.  Another good example is epinephrine and adrenaline being the same thing but being discovered for doing different jobs, one as a neurotransmitter, the other as a hormone.  
Jessica Lafferty (4 года назад)
wouldn't you say it seems to act as a hormone in ways within the kidney and as an enzyme in ways with angiotensinogen?  Your point really made me think.  Most people refer to renin as a hormone, I never realized it is generally considered an enzyme.
bobalitox zaza (4 года назад)
Thanks for the information. This was a great refresher.  Not only did it brush me up on my knowledge of the RASS, it also touched on the action of ACE Inhibitors and Vasopressin.  Great job
Tanya Field (4 года назад)
wow thank you for that!
Lanna S (4 года назад)
is it the enzyme ACE released by the endothelial cells that convert Angiotensin I into Angiotensin II? 
Tshering Dolkar (4 года назад)
yes it is ACE 
Zeeno Ali (4 года назад)
It has to be. I got confused too because i´ve learned that it´s ACE that convert Angiotensin I into Angiotensin II. But then I remembered that i happens in the endothelial cells.
SDGLifter (4 года назад)
Thanks for the great teaching. I'm not sure why the last three people who commented were on an education site. Keep up the great work! 
ELFCloudGamer (4 года назад)
You sounded like Chien-Po from Mulan in the beginning..
Gna Asm (5 лет назад)
the voice doesn't go with the face :(
CuppaChai11 (4 года назад)
Agh... to google, or not to google?? *despair*
Katie (5 лет назад)
thanks so much, you made that really clear :) bring on the exams!
Sha Sha (5 лет назад)
such a soothing voice you could read to me by my bedside...#prohomo
MrDnB89 (5 лет назад)
So what is the point in Aldosterone if Angiotensin 2 has the same effect on the kidney?
CuppaChai11 (4 года назад)
i think it DOUBLES the effect...
Erin Murphy (5 лет назад)
Really helpful -- thank you so much!
Oskar Abley (5 лет назад)
Thank you. Oskar
Alex Hunt (5 лет назад)
Renin is enzyme not hormone?
DrCinnamon (5 лет назад)
THANKS YOU SO MUCH!!! 14 minutes well spent!
alexa paz (5 лет назад)
thanks for the tutorial it was very helpful, does this mean Hypertension is also responsible for the urine output of a person?
James Norling (5 лет назад)
Absolutely brilliant at explaining, thank you !
Marnick Brems (5 лет назад)
the pituitary gland does not look like balls at all..
goldingsen (5 лет назад)
Your video's really helped me! One thing I would like to ask is... could you sometimes write bigger letters please?:) Your " smooth muscle" was a challenge to read :) Thank a lot!
xHaniffax (5 лет назад)
I laughed so hard!
Francesco Palazzo (5 лет назад)
There are actually several ACE-independant pathways.
leul endalamaw (5 лет назад)
there other things that control bp ,ANP that is activated when bp is rised and there is hypernatemia/elivation of Na ion and then the ANP on right atria is activated and acts on the collactnig tube of the kidney and leads excration of Na and retenssion of Ka,2 the prostaglandin ,nitric oxid and so on
Idan Korenblum (5 лет назад)
גdo you use a graphic tablet? what program do you use? thanks for the lectures, they are great
Thr (5 лет назад)
doesn't your SV decrease when the kidney holds more water, which doesn't get absorbed by the capillaries, which also doesn't increase blood volume?
arshass (5 лет назад)
Hi Almas! Tell Susu I say hi :) USMLE prep?
Gila Atwood (6 лет назад)
nice presentation! thankyou
khanacademymedicine (6 лет назад)
1. Yes, Going from A1 to A2 requires ACE 2. A2 has effects on the Prox. Conv. Tubule to reabsorb Na+ (this is not negligible) 3. Hypervolemia with Hyponatremia sounds like an SIADH type syndrome. In SIADH, GFR is high, so Renin levels are low. We will be doing an ANP video in the future to help describe its role.
khanacademymedicine (6 лет назад)
Angiotensin 2 is indeed a happy little fellow. =)

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