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Pagoclone: What We Know

Оценок: 347 | Просмотров: 11243
Pagoclone is a pharmaceutical substance that was under development for stuttering until the 2010s and was previously investigated for panic, anxiety, and premature ejaculation. It does not have a benzodiazepine structure, but it operates at the benzodiazepine site. Although it had some efficacy in panic and stuttering, it was not sufficient to maintain investment, so the drug has never been commercialized. It has occasionally been sold online, but its use outside of clinical research settings is minimal. TDC overview page (with references): https://thedrugclassroom.com/video/pagoclone/ Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/8o95nn/pagoclone_what_we_know/ ------------ Thank you to Ben/BronzeManul for help with the chemistry section and chemical structures. ------------ Donate to The Drug Classroom: https://www.patreon.com/TheDrugClassroom https://www.paypal.me/TheDrugClassroom Bitcoin: 1HsjCYpBHKcVCaW4uKBraCGkc1LK8xoj1B ------------ Thank you to my Patreon supporters: RollSafe.org, Gui Kirsch, Jonathon Dunn, Thomas Anaya, michael hoogwater, Beau Jaco, Alexander Pavlenko, Lars Nilsson, Billy, Abdulaziz Al-Kuwari, Sam A., Reece hosford, Felix Wisniewski, Jarrod o'connell, Daniel X Moore, Dahmon Bicheno, Christoffer Finstad, Zachary Thomas Binkley, Sami Parsegov, Dane Overman, Squadra Dumay, Dragonhax, Case van der Burg, John Riccardi, Matúš Zdút, Sebastian, Jacob Fournier-Paradis, Ben Shipp, Connor Sutton, Brian Henry, Adrian Selnes, Victor Stasek, Marty Sederberg, Eli Gilli Foldbo, Robert Slowley, Kate Crilly, Chandler Ledbetter, Garrett Troutman, and David Kernell. ------------ Facebook - http://facebook.com/thedrugclassroom Twitter - http://twitter.com/drugclassroom Email - seth@thedrugclassroom.com ------------ The Drug Classroom (TDC) is dedicated to providing the type of drug education everyone should have. Drugs are never going to leave our society and there has never been a society free from drugs. Therefore, it only makes sense to provide real education free from propaganda. TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring. Feel free to ask questions!
Категория: Образование
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Текстовые комментарии (118)
The Drug Classroom (4 месяца назад)
I’m finishing up research for a DXM overview, so that should be released next or after one more video. Because I’m splitting my time between The Drug Classroom and other work, it takes a while to put together overviews of bigger substances like DXM. That won’t always be the case, but for now there are some limitations on how fast I can release content.
One Night (3 месяца назад)
please do memantine!
Gadolini Rutherfordium (3 месяца назад)
You look like joker from full metal jacket
KittyCow (4 месяца назад)
Wonderful! Interesting to see what you find out because ive heard many non-evidence-backed claims such as its psychoactive effects being directly correlated to toxicity, as well as dangers associated with increasing the QT period.
󠀠 (4 месяца назад)
The Drug Classroom Hey, I love your videos, but there is one aspect of drugs that you and most people don't mention often: the "come down" or withdrawal symptoms (what someone will feel/experience if they stop using the drug or once the drug's effect wears off. I think this piece of information can be pretty important in some cases.
JaiWinter (4 месяца назад)
The Drug Classroom much love. We have all missed you. Would you mind doing an experience video / trip report on; Oxycodone Ketamine Or Dexedrine(Dextroamphetamine, or D-amphetamine) Please reply to my comment man, would you be interested in making some more experience/trip report videos?
Callum MacNeil (2 месяца назад)
Please make a video on clonidine
Tim Watz (3 месяца назад)
please do a video on Methcathinone.
Edge kain (3 месяца назад)
Could you do a video on 4-Methylaminorex
michaelemouse1 (3 месяца назад)
Please do a video on the different kinds of cannabis like distillates or edibles. As legal or semi-legal vendors offer an increasing diversity of novel options, many people are curious but confused. That would be quite relevant and would draw the interest of people who might otherwise not encounter your channel.
Gustavo Delacruz (3 месяца назад)
Doooo gabapentin!!
Trenton Bullard (3 месяца назад)
He’s already done it https://m.youtube.com/watch?v=TSP_MMtoHt0
Kian Abroshan (3 месяца назад)
Can you do MDAI
Ostrum (3 месяца назад)
Love what you’re doing. People need to get informed! Could you do a vid on nsi-189?
Alex DeLarge (3 месяца назад)
do lorazepam
One Night (3 месяца назад)
please do memantine!
ksanagi ksanagi (3 месяца назад)
Can you do a video on Piracetam?
Hunter Flowerson (3 месяца назад)
Hey Seth, could you cover Klonopin next? I feel like that’d be a really good one to go over, I’ve been hoping for a video on that for a few months, so hopefully you do. Barely any of my friends knew much about it but used, and I like sending your videos to friends interested in substances. I think given that it’s a kinda known in the drug scene yet kinda not type of drug it’d be a good idea, especially with comparing it to say a more common benzo like Xanax which drug users are more familiar with and might end up taking the same exact way. and keep the videos coming, longtime fan and love your objective and informative way of covering drugs, it really makes you standout. I love psychedsubstance but you’re easily the most informative drug channel. You deserve a lottt more subs for going so in-depth and being so educational. Thanks for the videos and I hope you’re having a good day
Proud Vaper (3 месяца назад)
Do CBD!!! I wanna know more about CBD because it’s a life saving drug.
Dominick247 (3 месяца назад)
Do a video about Datura!
DeadHouse (3 месяца назад)
You Should make a video on propylhexedrine. The active ingredient in Benzedrex
El Narcotraficante (3 месяца назад)
Yo seth could you make a video about cocain or crack? Probably the most used illegal stimulant out there
Mental Health with Dr Elliott (4 месяца назад)
Really interesting video. I wonder about its potential for diversion and misuse given that it can probably still be accessed online or illegally.....
Gunnar Gregurek (4 месяца назад)
Please please please do a video on 4-AcO-DMT ❤️
Pete Castle (4 месяца назад)
A+ Professional videos Seth, very helpful for people wanting to know what they are getting into! You've probably saved some lives, seriously. Could you please do a video of secobarbital? Trust me, it's still out there
Aussie Diltzenburger (4 месяца назад)
Can you please do a video on Clonazepam (Klonopin)?
Elias F (4 месяца назад)
Please do videos about diclazepam
rwerwee (4 месяца назад)
Can you do a video on scopolamin?
The Drug Classroom (4 месяца назад)
Yes, I will cover it.
First name Last name (4 месяца назад)
Hey Seth what happened to the LSA video, the one explaining Hawaiian baby woodrose and morning glory seeds, I can't find it, Thankyou Gareth
The Drug Classroom (4 месяца назад)
I removed it because it was not up to the standard I now have for TDC. A new video will be made.
First name Last name (4 месяца назад)
They've helped me so much with my cluster headaches, I'd like to share the video around
Colton Phillips (4 месяца назад)
What happened to your info on LSA? Your video is gone and so is its page on your site
Jake Lancaster (4 месяца назад)
Just a quick suggestion, when going over the molecule and naming (x) at (pos) highlight whatever is u are currently naming in the molecule!
󠀠 (4 месяца назад)
Hey, I love your videos, but there is one aspect of drugs that you and most people don't mention often: the "come down" or withdrawal symptoms (what someone will feel/experience if they stop using the drug or once the drug's effect wears off. I think this piece of information can be pretty important in some cases.
The Drug Classroom (4 месяца назад)
I usually describe the withdrawal symptoms and the comedown when that information is available.
stoeger 2 (4 месяца назад)
do choralbuterol i made some its so easy to make, after a couple of days of using it i found it is disgusting, with a headache that lasts days you can think normal but can't walk or talk straight. anyway still feeling it and it sucks.(there's a reason it's so easy to make be isn't because it is horrible be warned)
Danial3W (4 месяца назад)
Can you do a video on Hyoscine, im going on a vication to Colombia and I'm really scared.
Klel (4 месяца назад)
Do a video on nutmeg
Johnathan Corgan (4 месяца назад)
What was with the subtitle @ 3:06 spelling out The EXPRESS?
The Drug Classroom (4 месяца назад)
It was named the "Express" trial and they were pointing out which letters contributed to the name so that it could be abbreviated later on. Trial: https://clinicaltrials.gov/ct2/show/NCT00216255
JaiWinter (4 месяца назад)
I’ve missed you (:
GazB85 (4 месяца назад)
Could you please do a video on esters of morphine and codeine, other than heroin, one's that have or are used and their history, please?
662dodz (4 месяца назад)
Fasoracetam
Progressive Reality (4 месяца назад)
Hey! I am currently growing morning glories and I think we need your help - Can you make a video about Morning glory seeds?
KittyCow (4 месяца назад)
That's a bit of a stretch, I agree it wouldnt be this channels thing but growing morning glory is not close to "drug manufacturing".
Brian Smith (4 месяца назад)
why the fuck would he make a vid about that? why stop there? show us how to shake and bake some meth, seth! this is not what these videos are about. they are about HARM REDUCTION, not drug manufacturing, dude. I'm sure there's tek for morning glory seeds SOMEWHERE on YouTube. go find it. you'll never get it here, man.
imlee888 (4 месяца назад)
Phenibut please
Carlton Jones (4 месяца назад)
Could you do a video on Pyrazolam? It's a benzodiazepine that was made to be mostly anxiolytic rather than sedative and hypnotic like benzos typically are. Thank you!
The Senate (4 месяца назад)
Awesome work!
Merstreet (4 месяца назад)
Could you please make a video about Phenibut?
AssNasty (21 день назад)
Hes probably working on one honestly this man knows what's up.
Jake McCary (4 месяца назад)
Any chance you could do an overview on phenibut?
Pawesome Pal (2 месяца назад)
pretty sure he already did, if not he will. He took down some videos before because he didn't think he did a good enough job presenting the info.
bernard wallace (4 месяца назад)
Thanx(as always) for the video seth.... Keep up the good work!
PsychoticScientist (4 месяца назад)
3-MeO-PCE if there’s enough info out there would be interesting to see a video on.
SAVROMx (4 месяца назад)
Do a video about phenobarbital
Habla Mierda (2 месяца назад)
Yea that’d be awesome. Most Barbiturates are so uncommon now that some info about them would be interesting. I read phenobarbital is still used for epilepsy sometimes, I get Fioricet (butalbital) prescribed for migraines and it’s way more recreational than Valium or Ativan.
SAVROMx (4 месяца назад)
Captinpixles yea, about any barb maby, but me personally I try only phenobarbital
Captinpixles (4 месяца назад)
it sucks, why? any other barb is 1000x better
truth seeker (4 месяца назад)
how do you get this stuff and has anybody tried from you guys
William Ezell (4 месяца назад)
So its a gaba a agonist but its not very sedating? That's pretty weird/interesting. Especially considering how sedating zopiclone is. I wonder if it fucks with memory like related z drugs and benzos.
Keith M (4 месяца назад)
Generally speaking, when I think GABA-A agonist, i think Muscimol, the hallucinogen in Amanita Muscaria and Amanita Pantherina. Which is really sedating, relaxing and can be quite trippy at larger doses. Zolpidem, interestingly has some of the same properties. The GABA-A agonism makes me wonder if Pagoclone could be a hallucinogen without the sedation associated with other Z Drugs and Muscimol, very interesting topic to ponder on.
Rob Lewis (4 месяца назад)
William Ezell Pyrazolam is similar.
DIGITAL VHS (4 месяца назад)
Educational content saves lives, keep at it Seth. Hope you bring back the podcasts when you can!
Keta_Meen 420 (4 месяца назад)
Can you do a video on DMMA - 2,5-DIMETHOXY-3,4-METHYLENEDIOXYAMPHETAMINE  its basically MDA with a Dimethoxy group to look like 2CB and MDA had a crazy love child
David Stacey (4 месяца назад)
Can you do a video on citalopram? My mom takes it daily im curious
freeBSD gamer (4 месяца назад)
just watch the one about sertaline, it has the same effects
Wytse Wolf (4 месяца назад)
Why do you make videos about substances that are so rarely used? I mean, cool video and it's interesting to know about, but it's not really helping many people I think. I think it's better to make videos about RC's nowadays, or meds that are used often.
Garbage Hunters (4 месяца назад)
You have to remember there is a lot of information on RC’S, and although more interesting to know about as you may come into contact with them this more niche video can also be extremely beneficial to a student studying in this specific interest. Anyway an extra video doesn’t harm anyone
bernard wallace (4 месяца назад)
Abishai Vallthce : i too am a fan of TDC's videos for the somewhat more rare substances. Being that Seth's videos are information based and without bias(from social stigma, etc), i feel like the more info, the better when it comes to new substances or ones that aren't heavily researched.
Abishai Vallance (4 месяца назад)
I like the rare ones alot and hope he makes more :)
The Drug Classroom (4 месяца назад)
It depends on how much time I have to work on something, this was an easier video to create in a short period of time and it helps with diversity on the channel. In general I do stick to widely used drugs, RCs, and medications though. This is one of the few departures from that.
michaelemouse1 (4 месяца назад)
I recently heard of Bromantane (aka Ladasten) and it's intriguing. It was a performance-enhancing drug the Soviet Union gave to their soldiers and athleles which makes it sound scary but nearly everyone I've read on it seems to be saying it's wonderful. I'm wondering what you think about it. Maybe a video about it would interest other people too?
michaelemouse1 (4 месяца назад)
I hear it takes 1-2 weeks to have an effect and takes about that long to wear off. Was that your experience too? Did you try more than 100mg?
willjfowler (4 месяца назад)
I tried bromantane a few times, daily doses around 50-100 mg for about a month at a time. It was a subtle experience for me, but others commented on my different personality (increased confidence, better work quality, etc). I did suffer from less quantity of work but what I did make was much better.
michaelemouse1 (4 месяца назад)
There seems to be even less information about that. Could you tell me a little about it?
ImGoingSSJ (4 месяца назад)
agreed. Also it's relative: adamantane.
Fluffed Pillows (4 месяца назад)
Watch this show up on the RC market in a month
omsonic (4 месяца назад)
Excellent video as always ! could you do a video on Bacopa monnieri ?
Mallard The Ducking Head aka Brian (4 месяца назад)
Where to get it???
Mallard The Ducking Head aka Brian (4 месяца назад)
Damian Michniewski Thanks, but you probably need a license of some sort. It seems like the good RC sites cannot ship anymore even though it's not illegal where I'm at.
Mallard The Ducking Head aka Brian (4 месяца назад)
Brian Smith you're right, 😁
Brian Smith (4 месяца назад)
hey! you're not me!
Damian Michniewski (4 месяца назад)
https://pubchem.ncbi.nlm.nih.gov/compound/Pagoclone#section=Chemical-Vendors
Wytse Wolf (4 месяца назад)
it's probably a prescription medicine
Evelyn Pugh (4 месяца назад)
Yay a new video!
THE MARTYR (4 месяца назад)
Is dmx a pleasant experience?
PHIL MAGICK (4 месяца назад)
It brings visions of pitbulls fighting
Its Fantom (4 месяца назад)
THE MARTYR My personal favorite is lsd and if your a big fan of psychedelics as well I’d say Dxm is definitely worth a try. I absolutely loved it. Just as warning tho past the 3rd plateu things can get really weird lol
Its Fantom (4 месяца назад)
THE MARTYR Np fam. Harm reduction is extremely important. I Can provide info on various other substances like lsd, dob, dph, clonazepam etc etc
THE MARTYR (4 месяца назад)
Its Fantom I was looking for more of a psychedelic experience do you think I should just stick to shrooms and acid or is dxm something you have to try at least once I seen some trip reports on erowid that's kind of turned me off trying it
THE MARTYR (4 месяца назад)
Its Fantom thank you for detailed information from your experiences you have provided it means alot that you care about harm reduction
zippeduniform3 (4 месяца назад)
Second
J (4 месяца назад)
Yeah

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