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Pagoclone: What We Know

Оценок: 369 | Просмотров: 13396
Pagoclone is a pharmaceutical substance that was under development for stuttering until the 2010s and was previously investigated for panic, anxiety, and premature ejaculation. It does not have a benzodiazepine structure, but it operates at the benzodiazepine site. Although it had some efficacy in panic and stuttering, it was not sufficient to maintain investment, so the drug has never been commercialized. It has occasionally been sold online, but its use outside of clinical research settings is minimal. TDC overview page (with references): https://thedrugclassroom.com/video/pagoclone/ Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/8o95nn/pagoclone_what_we_know/ ------------ Thank you to Ben/BronzeManul for help with the chemistry section and chemical structures. ------------ Donate to The Drug Classroom: https://www.patreon.com/TheDrugClassroom https://www.paypal.me/TheDrugClassroom Bitcoin: 1HsjCYpBHKcVCaW4uKBraCGkc1LK8xoj1B ------------ Thank you to my Patreon supporters: RollSafe.org, Gui Kirsch, Jonathon Dunn, Thomas Anaya, michael hoogwater, Beau Jaco, Alexander Pavlenko, Lars Nilsson, Billy, Abdulaziz Al-Kuwari, Sam A., Reece hosford, Felix Wisniewski, Jarrod o'connell, Daniel X Moore, Dahmon Bicheno, Christoffer Finstad, Zachary Thomas Binkley, Sami Parsegov, Dane Overman, Squadra Dumay, Dragonhax, Case van der Burg, John Riccardi, Matúš Zdút, Sebastian, Jacob Fournier-Paradis, Ben Shipp, Connor Sutton, Brian Henry, Adrian Selnes, Victor Stasek, Marty Sederberg, Eli Gilli Foldbo, Kate Crilly, Chandler Ledbetter, Garrett Troutman, and David Kernell. ------------ Facebook - http://facebook.com/thedrugclassroom Twitter - http://twitter.com/drugclassroom Email - seth@thedrugclassroom.com ------------ The Drug Classroom (TDC) is dedicated to providing the type of drug education everyone should have. Drugs are never going to leave our society and there has never been a society free from drugs. Therefore, it only makes sense to provide real education free from propaganda. TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring. Feel free to ask questions!
Категория: Образование
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Текстовые комментарии (120)
The Drug Classroom (7 месяцев назад)
I’m finishing up research for a DXM overview, so that should be released next or after one more video. Because I’m splitting my time between The Drug Classroom and other work, it takes a while to put together overviews of bigger substances like DXM. That won’t always be the case, but for now there are some limitations on how fast I can release content.
One Night (6 месяцев назад)
please do memantine!
Gadolini Rutherfordium (6 месяцев назад)
You look like joker from full metal jacket
KittyCow (7 месяцев назад)
Wonderful! Interesting to see what you find out because ive heard many non-evidence-backed claims such as its psychoactive effects being directly correlated to toxicity, as well as dangers associated with increasing the QT period.
(7 месяцев назад)
The Drug Classroom Hey, I love your videos, but there is one aspect of drugs that you and most people don't mention often: the "come down" or withdrawal symptoms (what someone will feel/experience if they stop using the drug or once the drug's effect wears off. I think this piece of information can be pretty important in some cases.
JaiWinter (7 месяцев назад)
The Drug Classroom much love. We have all missed you. Would you mind doing an experience video / trip report on; Oxycodone Ketamine Or Dexedrine(Dextroamphetamine, or D-amphetamine) Please reply to my comment man, would you be interested in making some more experience/trip report videos?
Yahav itah (1 месяц назад)
Teva pronounced teva not tiva Means nature in hebrew
Callum MacNeil (5 месяцев назад)
Please make a video on clonidine
Tim Watz (6 месяцев назад)
please do a video on Methcathinone.
Edge kain (6 месяцев назад)
Could you do a video on 4-Methylaminorex
michaelemouse1 (6 месяцев назад)
Please do a video on the different kinds of cannabis like distillates or edibles. As legal or semi-legal vendors offer an increasing diversity of novel options, many people are curious but confused. That would be quite relevant and would draw the interest of people who might otherwise not encounter your channel.
Gustavo Delacruz (6 месяцев назад)
Doooo gabapentin!!
Trenton Bullard (6 месяцев назад)
He’s already done it https://m.youtube.com/watch?v=TSP_MMtoHt0
Kian Abroshan (6 месяцев назад)
Can you do MDAI
Ostrum (6 месяцев назад)
Love what you’re doing. People need to get informed! Could you do a vid on nsi-189?
Alex DeLarge (6 месяцев назад)
do lorazepam
One Night (6 месяцев назад)
please do memantine!
ksanagi ksanagi (6 месяцев назад)
Can you do a video on Piracetam?
Hunter Flowerson (6 месяцев назад)
Hey Seth, could you cover Klonopin next? I feel like that’d be a really good one to go over, I’ve been hoping for a video on that for a few months, so hopefully you do. Barely any of my friends knew much about it but used, and I like sending your videos to friends interested in substances. I think given that it’s a kinda known in the drug scene yet kinda not type of drug it’d be a good idea, especially with comparing it to say a more common benzo like Xanax which drug users are more familiar with and might end up taking the same exact way. and keep the videos coming, longtime fan and love your objective and informative way of covering drugs, it really makes you standout. I love psychedsubstance but you’re easily the most informative drug channel. You deserve a lottt more subs for going so in-depth and being so educational. Thanks for the videos and I hope you’re having a good day
Proud Vaper (6 месяцев назад)
Do CBD!!! I wanna know more about CBD because it’s a life saving drug.
Dominick247 (6 месяцев назад)
Do a video about Datura!
ISOMER (6 месяцев назад)
You Should make a video on propylhexedrine. The active ingredient in Benzedrex
Mental Health with Dr Elliott (7 месяцев назад)
Really interesting video. I wonder about its potential for diversion and misuse given that it can probably still be accessed online or illegally.....
Gunnar Gregurek (7 месяцев назад)
Please please please do a video on 4-AcO-DMT ❤️
Pete Castle (7 месяцев назад)
A+ Professional videos Seth, very helpful for people wanting to know what they are getting into! You've probably saved some lives, seriously. Could you please do a video of secobarbital? Trust me, it's still out there
Aussie Diltzenburger (7 месяцев назад)
Can you please do a video on Clonazepam (Klonopin)?
Elias F (7 месяцев назад)
Please do videos about diclazepam
William Schutz (2 месяца назад)
Elias F I was expecting something kinda weak like valium. But I took a heroic dose and blacked out for 3 days.
rwerwee (7 месяцев назад)
Can you do a video on scopolamin?
The Drug Classroom (7 месяцев назад)
Yes, I will cover it.
First name Last name (7 месяцев назад)
Hey Seth what happened to the LSA video, the one explaining Hawaiian baby woodrose and morning glory seeds, I can't find it, Thankyou Gareth
The Drug Classroom (7 месяцев назад)
I removed it because it was not up to the standard I now have for TDC. A new video will be made.
First name Last name (7 месяцев назад)
They've helped me so much with my cluster headaches, I'd like to share the video around
Colton Phillips (7 месяцев назад)
What happened to your info on LSA? Your video is gone and so is its page on your site
Jake Lancaster (7 месяцев назад)
Just a quick suggestion, when going over the molecule and naming (x) at (pos) highlight whatever is u are currently naming in the molecule!
(7 месяцев назад)
Hey, I love your videos, but there is one aspect of drugs that you and most people don't mention often: the "come down" or withdrawal symptoms (what someone will feel/experience if they stop using the drug or once the drug's effect wears off. I think this piece of information can be pretty important in some cases.
The Drug Classroom (7 месяцев назад)
I usually describe the withdrawal symptoms and the comedown when that information is available.
stoeger 2 (7 месяцев назад)
do choralbuterol i made some its so easy to make, after a couple of days of using it i found it is disgusting, with a headache that lasts days you can think normal but can't walk or talk straight. anyway still feeling it and it sucks.(there's a reason it's so easy to make be isn't because it is horrible be warned)
Danial3W (7 месяцев назад)
Can you do a video on Hyoscine, im going on a vication to Colombia and I'm really scared.
Klel (7 месяцев назад)
Do a video on nutmeg
Johnathan Corgan (7 месяцев назад)
What was with the subtitle @ 3:06 spelling out The EXPRESS?
The Drug Classroom (7 месяцев назад)
It was named the "Express" trial and they were pointing out which letters contributed to the name so that it could be abbreviated later on. Trial: https://clinicaltrials.gov/ct2/show/NCT00216255
JaiWinter (7 месяцев назад)
I’ve missed you (:
GazB85 (7 месяцев назад)
Could you please do a video on esters of morphine and codeine, other than heroin, one's that have or are used and their history, please?
662dodz (7 месяцев назад)
Fasoracetam
Progressive Reality (7 месяцев назад)
Hey! I am currently growing morning glories and I think we need your help - Can you make a video about Morning glory seeds?
KittyCow (7 месяцев назад)
That's a bit of a stretch, I agree it wouldnt be this channels thing but growing morning glory is not close to "drug manufacturing".
Brian Smith (7 месяцев назад)
why the fuck would he make a vid about that? why stop there? show us how to shake and bake some meth, seth! this is not what these videos are about. they are about HARM REDUCTION, not drug manufacturing, dude. I'm sure there's tek for morning glory seeds SOMEWHERE on YouTube. go find it. you'll never get it here, man.
imlee888 (7 месяцев назад)
Phenibut please
kendrickeyy (7 месяцев назад)
Could you do a video on Pyrazolam? It's a benzodiazepine that was made to be mostly anxiolytic rather than sedative and hypnotic like benzos typically are. Thank you!
The Senate (7 месяцев назад)
Awesome work!
Merstreet (7 месяцев назад)
Could you please make a video about Phenibut?
AssNasty (3 месяца назад)
Hes probably working on one honestly this man knows what's up.
Jake McCary (7 месяцев назад)
Any chance you could do an overview on phenibut?
Pawesome Pal (5 месяцев назад)
pretty sure he already did, if not he will. He took down some videos before because he didn't think he did a good enough job presenting the info.
bernard wallace (7 месяцев назад)
Thanx(as always) for the video seth.... Keep up the good work!
PsychoticScientist (7 месяцев назад)
3-MeO-PCE if there’s enough info out there would be interesting to see a video on.
SAVROMx (7 месяцев назад)
Do a video about phenobarbital
Kyle MD (5 месяцев назад)
Yea that’d be awesome. Most Barbiturates are so uncommon now that some info about them would be interesting. I read phenobarbital is still used for epilepsy sometimes, I get Fioricet (butalbital) prescribed for migraines and it’s way more recreational than Valium or Ativan.
SAVROMx (7 месяцев назад)
Captinpixles yea, about any barb maby, but me personally I try only phenobarbital
cap (7 месяцев назад)
it sucks, why? any other barb is 1000x better
truth seeker (7 месяцев назад)
how do you get this stuff and has anybody tried from you guys
William Ezell (7 месяцев назад)
So its a gaba a agonist but its not very sedating? That's pretty weird/interesting. Especially considering how sedating zopiclone is. I wonder if it fucks with memory like related z drugs and benzos.
Keith M (7 месяцев назад)
Generally speaking, when I think GABA-A agonist, i think Muscimol, the hallucinogen in Amanita Muscaria and Amanita Pantherina. Which is really sedating, relaxing and can be quite trippy at larger doses. Zolpidem, interestingly has some of the same properties. The GABA-A agonism makes me wonder if Pagoclone could be a hallucinogen without the sedation associated with other Z Drugs and Muscimol, very interesting topic to ponder on.
Rob Lewis (7 месяцев назад)
William Ezell Pyrazolam is similar.
DIGITAL VHS (7 месяцев назад)
Educational content saves lives, keep at it Seth. Hope you bring back the podcasts when you can!
Keta_meen 2501 (7 месяцев назад)
Can you do a video on DMMA - 2,5-DIMETHOXY-3,4-METHYLENEDIOXYAMPHETAMINE  its basically MDA with a Dimethoxy group to look like 2CB and MDA had a crazy love child
David Stacey (7 месяцев назад)
Can you do a video on citalopram? My mom takes it daily im curious
freeBSD gamer (7 месяцев назад)
just watch the one about sertaline, it has the same effects
Wytse Wolf (7 месяцев назад)
Why do you make videos about substances that are so rarely used? I mean, cool video and it's interesting to know about, but it's not really helping many people I think. I think it's better to make videos about RC's nowadays, or meds that are used often.
Garbage Hunters (7 месяцев назад)
You have to remember there is a lot of information on RC’S, and although more interesting to know about as you may come into contact with them this more niche video can also be extremely beneficial to a student studying in this specific interest. Anyway an extra video doesn’t harm anyone
bernard wallace (7 месяцев назад)
Abishai Vallthce : i too am a fan of TDC's videos for the somewhat more rare substances. Being that Seth's videos are information based and without bias(from social stigma, etc), i feel like the more info, the better when it comes to new substances or ones that aren't heavily researched.
Abishai Vallance (7 месяцев назад)
I like the rare ones alot and hope he makes more :)
The Drug Classroom (7 месяцев назад)
It depends on how much time I have to work on something, this was an easier video to create in a short period of time and it helps with diversity on the channel. In general I do stick to widely used drugs, RCs, and medications though. This is one of the few departures from that.
michaelemouse1 (7 месяцев назад)
I recently heard of Bromantane (aka Ladasten) and it's intriguing. It was a performance-enhancing drug the Soviet Union gave to their soldiers and athleles which makes it sound scary but nearly everyone I've read on it seems to be saying it's wonderful. I'm wondering what you think about it. Maybe a video about it would interest other people too?
michaelemouse1 (7 месяцев назад)
I hear it takes 1-2 weeks to have an effect and takes about that long to wear off. Was that your experience too? Did you try more than 100mg?
willjfowler (7 месяцев назад)
I tried bromantane a few times, daily doses around 50-100 mg for about a month at a time. It was a subtle experience for me, but others commented on my different personality (increased confidence, better work quality, etc). I did suffer from less quantity of work but what I did make was much better.
michaelemouse1 (7 месяцев назад)
There seems to be even less information about that. Could you tell me a little about it?
ImGoingSSJ (7 месяцев назад)
agreed. Also it's relative: adamantane.
Andrew (7 месяцев назад)
Watch this show up on the RC market in a month
omsonic (7 месяцев назад)
Excellent video as always ! could you do a video on Bacopa monnieri ?
glowduck (7 месяцев назад)
Where to get it???
glowduck (7 месяцев назад)
Damian Michniewski Thanks, but you probably need a license of some sort. It seems like the good RC sites cannot ship anymore even though it's not illegal where I'm at.
glowduck (7 месяцев назад)
Brian Smith you're right, 😁
Brian Smith (7 месяцев назад)
hey! you're not me!
Damian Michniewski (7 месяцев назад)
https://pubchem.ncbi.nlm.nih.gov/compound/Pagoclone#section=Chemical-Vendors
Wytse Wolf (7 месяцев назад)
it's probably a prescription medicine
- - (7 месяцев назад)
Yay a new video!
THE MARTYR (7 месяцев назад)
Is dmx a pleasant experience?
PHIL MAGICK (7 месяцев назад)
It brings visions of pitbulls fighting
Its Fantom (7 месяцев назад)
THE MARTYR My personal favorite is lsd and if your a big fan of psychedelics as well I’d say Dxm is definitely worth a try. I absolutely loved it. Just as warning tho past the 3rd plateu things can get really weird lol
Its Fantom (7 месяцев назад)
THE MARTYR Np fam. Harm reduction is extremely important. I Can provide info on various other substances like lsd, dob, dph, clonazepam etc etc
THE MARTYR (7 месяцев назад)
Its Fantom I was looking for more of a psychedelic experience do you think I should just stick to shrooms and acid or is dxm something you have to try at least once I seen some trip reports on erowid that's kind of turned me off trying it
THE MARTYR (7 месяцев назад)
Its Fantom thank you for detailed information from your experiences you have provided it means alot that you care about harm reduction
zippeduniform3 (7 месяцев назад)
Second
J (7 месяцев назад)
Yeah

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