Stanford Professor Robert Sapolsky, posits that depression is the most damaging disease that you can experience. Right now it is the number four cause of disability in the US and it is becoming more common. Sapolsky states that depression is as real of a biological disease as is diabetes.
Stanford University Channel on YouTube:
Tipul asta chiar stie ce zice. Totusi, trebuie abordata problema si social, nu doar biologic. Cele doua se intrepatrund. Si din ce am citit din surse mai putin main stream, genele nu sunt fixe, prezinta versiuni alele si interpretarea lor depinde de factorii de mediu care schimba enzimele responsabile pentru descifrarea lor. E mult prea complicata treaba, nu stiu cum s-o rezolvi medicamentos. Plus ca si medicamentele, ca sa zic asa, unele is bune altele is nebune.
i got out of the psych ward just a few days ago (on the 26th) after my suicide attempt. Im a junior biochem major but I missed my finals this semester. Any student who noticed I was gone probably still thinks that I dropped out. I would try to explain it to my professors if I could even explain it to myself.
There was just endless tragic, you know, driveby shootings of Norepinephrine people, by the Serotonin crowd, or the otherway around. Huge, huge controversy. And of course like the middle of the road, Liberals: why can't we all get along?
i think, at least in my experience, there is still a component of "pull yourself together" because i only got rid of my depression when i finally decided "I've got to break this cycle of self loathing"
Read the myth of mental illness or watch a summary of it online, people with depression are not victims they have great influence on their situation. (Doenst mean you can fix it and it's your fault, it means that you are able to improve your situation)
Wow, I always thought I couldn't be MDD because my mood is so cyclical, usually I have two weeks of feeling completely normal amd a month or two of feeling guilty and sad on a good day.
Surprisingly I am always better around winter, so I feel pretty okay right now
I recommended this video to you because your friend decided that you should figure your depression out for yourself. You seemed conflicted about the experience and I thought you would feel better with more understanding. I needed to use the restroom. My phone died, but I wanted to talk to you more. If you see this, I am here to talk to about depression. 😥
"It's a strange poverty of the English language, and indeed of many other languages, that we use the same word "depression" to describe how a kid feels when it rains on his birthday, and to describe how somebody feels the minute before they commit suicide."
Andrew Solomon, TED Talk Depression, the Secret we Share.
The people on here with depression or anxiety. Exercise!!!! You won't want to, you'll convince yourself it's not helping, but it is your best medicine. Second. Don't judge anyone or any activity. Don't judge yourself. You are who you are. Try things out to see if you like it, if not move on. Eat right. Limit sugars. Don't count fruit as sugars. Also, don't fear trying medication. Find a caring competent physician and work with them. And again.....excercise religiously. Studies find that exercise is more effective than any other tactic.
Did you even watch the lecture? One of the defining symptoms of mdd are anhedonia and psychomotor retardation. Anhedonia means you have loss the pleasure for doing something. If you loss interest, for say exercise how can you even start exercising? Dont tell me stupid voalition or will power. You dont force someone that having cripples leg for marathon. Same as psychomotor retardation. You limbs and legs feels heavy. How the fuck you gonna jog with that kind of symptoms, when the defining symptoms of mdd is laying on bed for hours.
Yes depression can happen for everyone. And yes. Some people can go to other of happiness again with exercising or healthy diet. But NOT all. MDD is pretty bad where even with exercise or diet or thousands of cbt. You still cannot feel happy or escape the anhedonia. And that is when medical intervention is needed.
I never leave comments, but BOY I needed to leave one now!
WHAT IS WRONG WITH THESE PEOPLE??? ( in Sapolsy-an: WHAT'S UP WITH THESE PEOPLE??)
I went through all the lectures available, this one is as exciting and insightful as any other, but the audience is KILLING ME!
WHAT IS SO FUNNY ABOUT THIS?? HE IS TALKING ABOUT DEPRESSION, NOT FUNNY!!!!!
I think that even professor Sapolsky is embarrassed by their behavior. Jeeeez!!!
Thanks for this. I don't think depression will ever become socially acceptable like other disorders are. Behavior gets too mixed up with personality, and people get demonized for being weak, sad and self-absorbed/narcissistic. The symptoms are too nebulous, too blurry with character flaws, and people make the attribution error where they blame character over situation. It's always going to be a double bind for the depressed person.
Depression sucks! After years and years of isolation and self medicating , self destructive behavior I had a major manic depressive episode, which I almost couldn’t bare anymore. With no one to talk to or will listen, I showed up at my moms house and unloaded everything I was going through. She was able to get me help from a doctor who put me on a SSRI. After 6-8 months of daily meds I finally starting to feel good with myself. My drug use tho not gone has decreased dramatically. I left the USA for 2 months and sobered up in Japan, after taking 10 hits of LSD in Tokyo. I literally saw my old self die and the new me emerged. Just my experience, I wanted to share! Good luck to anyone fighting depression! I don’t think we can ever be cured but I’ve escape my own personal hell and I’m trying hard to not go back!
People keep complaining about the laughter. But it is natural, hell, I chuckled a little during this. Don’t say it’s because I haven’t suffered. I have been hospitalized multiple times for attempts of suicide. I have gone through depression, and I’m still in it. Laughter here is the need for the subject to be lightened some, to prevent sadness from taking affect. In my Holocaust studies class, there would be days where we would talk and joke because it helps keep us stable, to help us not break down. As an example, I use my depression as a joke sometimes because it’s the easiest way for me to talk about it. Overall I don’t take ANY of the laughter as a personal attack, and I suggest you don’t either, no one in that room is trying to put you down. Great talk!
sold the car.. bike everywhere,mix with positive people,eat non allergenic healthy food,Vit B-fish oil-etc,God in my life,structure in my life like work,...having a significant other ,investing in family,and when you are too depressed to do something , just do it!
One biggy was when I was in my early 20`s my friend told me I was very negative and she put a rubber band on my wrist and said every time I have a negative thought, ping the rubber band and change it to a positive thought and it worked.. it sounds trite and simplistic but it made me realise how negative I was..AND...Be kind to yourself and others.Recovering from depression is very holistic.My whole birth family were and are depressives.I fought back.
Here is my advice :
I have no clue about Neurology but I feel experienced in philosophy, naturally :)
So ! what if depression is "natural" ? what if it isnt ment by nature to be "bad" ?
isnt it strange that it may occur when one loses a family member at young age?
There is this old Latin saying "memento mori"
so you see, some cultures/philosophies were concerned with how to think more about death , and not like depressed people how to think less of it...
all I wanna say is that I think that depressed people are simply people who got introduced to the subject of death sooner than others... they entered "midlife crysis" sooner than supposed, sooner than others
Nietzsche wrote : " some grow old first with their heart, others with their soul "
so these people, how now become acquitted/enlightened/conscious about the subject of DEATH and they can no longer forget it
and maybe its in the nature of things, that one SHOULDNT forget it, that nature doesnt want you to forget it once you think about it...
so they try to become no longer depressed by trying to "forget" something one cant forget by nature
so this is my thesis
I wont tell you to go on trying to forget or to take some medicine that will help you to forget
but I believe philosophy/religion/spirituality has the ability to CHANGE your view about DEATH
to persuade/show you that its not a SAD subject in itself, that your sadness comes precisely from the misunderstanding that DEATH IS SAD
i dont mean that you should start think that DEATH IS GOOD AND SHOULD BE SPREAD O.o nopeeeee......
I mean that death is NATURAL, it is neutral, to a conscious enlightened being it is a passage, a transformation...
you have been "made wise" / forced into wisdom to soon, normally people get into it with age 50 but you are there now and there is no go back
so what I wanted to recommend you, just in case you have tried everything else and it didnt work
start with Buddhism
watch Jordan Petersons speech on Buddhism :
and now try OSHO on youtube :
I specifically recommend :
Being in Love : https://www.youtube.com/watch?v=8LfUvi1bof8
Love and Hate are one : https://www.youtube.com/watch?v=5-7JSIDgcLk
A Buddha will be misunderstood : https://www.youtube.com/watch?v=-nSMi0whFEA
especially this one with music,
I watch this since years and cry tears of pleasure every single time
Osho "life has no goal, no purpose" : https://www.dailymotion.com/video/x3hnem5
so don't fight it, since there is nothing to fight
don't try to "overcome" it, don't try to ignore it
jump into it, and you will see, it will disappear
people experiencing with breathing techniques like Wim Hof PROOVE !! that our endocrine/hormone system is secondary ! that we can affect it by thoughts and meditation !
just watch the beginning of this clip :
so, as if coming out even of the biggest depression wasn't enough
try this to become happier than 95% of people
do this Wim Hof breathing technique : https://www.youtube.com/watch?v=RW1C_3OXhEs
WHILE LISTENING TO ONE OF THESE TWO :
the more rapid ESTAS TONNE GUITAR : https://www.youtube.com/watch?v=WGTxqhSN8bE
the more slow SHAMAN DRUM : www.youtube.com/watch?v=IWIbdQ0K88E&t=1s
courage to you
and tell me if it helped or not
This is not fact - this is opinion (by definition). In short... we will drill holes in your head , we will experiment with random drugs, stimulate parts of your brain with probes, etc. to get semi-conclusive results. [and people with ponytails will attempt to pretend they understand conscious]
This is a great lecture. Most people who don't understand, just say snap out of it, or don't be sad. It just irritates me so much. If I could snap out of it, I would have a long time ago. I have Major Depression, ADHD, Anxiety Disorder for all of my life.
Excellent lecture. His book on behavior is extremely impressive. Could do without some of the audience members laughing at bizarre times, not bizarre to them, but bizarre to the intelligent and compassionate.
how freaking stupid are these people to laugh during a class at such a debilitation biological sever enough to set the thoughts in human behavior to points of suicide, harming themselves, or someone they love dearly. i find them horrid, umempathic, and so stupid it's horrifying. so sad. i am unable to imagine this is the world where we live. it's beyond belief they have no clue the difference in stress, anxiety, and depression. these are people so insensitive it is contemptible. this class is what stands to treat such a disabled human being? ... i am appalled at their behavior. And the opportunity for those who imho are disrespecting themselves you and lend society no competence to treat another human. i can only feel sorry for them you and their missed opportunity. i am not able to imagine how depressing it was for you teaching this day.
thank you r s. love your courage and composure.
One should add though that Major Depressive Disorder can also come with Overeating and Hypersomnia. The DSM 5 explicitly lists INCREASE OR DECREASE in appetite (and body weight), as well as INSOMNIA OR HYPERSOMNIA as diagnostic criteria.
Depression messes with appetite and sleep, but it can do that in several ways.
Someone watching this lecture without reading the DSM5, relevant studies and other sources might not be able to detect all signs of depression/MDD afterwards. Imagine a MP, often the first health professional a depressed person contacts, wanting to brush up on her knowledge of Depression, watching this lecture and then withholding proper treatment to a patient on the grounds that they dont have a lack of appetite, but overeat instead, and don't wake up early in the morning, but sleep all day long.
Doc says: You don't have depression. Can't be.
The patient protests, and the MP gets out her laptop and plays the part of the lecture, where Sapolsky says: "That is not what you see in Major Depression."
Patient looks increasingly disturbed.
MP shrugs like Seinfeld and that's that.
The problem ist that statements like that sound quite definite coming from such an eminent, famous man. That is why it is so dangerous. Because he is so famous and influential.
Worst case scenario: A deeply depressed person is told that she is not depressed, because she suffers from hypersomnia instead of Insomnia, doesn't receive proper treatment, or is even labelled a malingerer and commits suicide.
The social environment of the depressed person might react similiarly after watching this video.
"You are just fat, greedy and lazy, not depressed! Otherwise you would wake up in the mornings and you wouldn't stuff that cake in your face!"
Also the depiction of the research history and the neurochemistry of depression invites misunderstanding. MAOIs decrease the breakdown of Serotonin and Dopamine as well as that of Norepinephrine. It might be that some scientiststs back in the sixties thought that the efficacy of MAOIs in treating MDD did indeed prove the Norepinephrine-Hypothesis of Depression, but they might just as well have seen it as support for the Serotonin-Hypothesis of Depression, which came up in the sixties as well. It should however be made very clear to the audience that MAOIs also increase Serotonin, Dopamine, Norepinephrine in the brain.
The reason why SSRIs have the first S Selective in their name is that, in contrast to earlier antidepressants like Tricyclics they did not work on different neurotransmitter systems at the same time, or at least they were not supposed to.
It appears that scientists did think that the early antidepressants worked exclusively on norepinephrine. Just read the passage about Depression in his book "Why Zebras don't get Ulcers", where it is made very clear that MAOIs and Tricyclics work on the different neurotransmitters. BUT: The problem with the appetite and sleep is also to be found in the book.
This is awesome! Thank you Prof Sapolsky. I'm taking a class on vulnerability to depression, and your lecture gives a beautiful overview of the history of research on depression and in the end links vulnerability and stress together...Definitely recommend !
Is depression a disease or is this grossly dysfunctional collective society we have found ourselves in a disease? Does the key problem rest in an individuals brain or in humanity as a whole? Not all things can be explained by placing it in a labeled box and poking at it with metal instruments.
Each individual's circumstances should be considered and if there is nothing that can be done to help the person and the person is determined to die then they should be able to access the means to die a quick, painless and dignified death regardless of whether they are terminally ill or not. I can not stand these Anti- Sucide campaigns as they do not care at all about how the person came to be sucidal, all they care about is stopping the person from killing themselves, their motto is that you should continue to exist NO MATTER WHAT, quality of life being irrelevant. We live in a society and system obessed only with quantity of life and not quality of life. Quality of life is much more important than quantity of life, given the choice, if I was given the option of choosing between 5 more years of life but great 5 years of life and given 40 more years of life but miserable ones then I would take the great 5 years of life anytime. Quality of life over quantity just for the sake of quantity. Unfortunately we live in a society and system obessed only with Quantity of Life and NOT Quality of Life after all the longer one exists the more one consumes and the more money is made out of the individual hence " let's keep everyone existing for as long as possible no matter their quality of life or lack of it." As someone who was abandoned and abused as a child to then be adopted by 2 abusers at age of 5 and who because of that tried taking my own life within a month of turning 16 and then moved to a country at 19 where making friends has been impossible for me and there therefore have now lived my entire adult life all on my own ( 34 now ) and NO I don't have Asperger's or some personality disorder or Bipolar.When I lived in country of birth I had a few friends and never felt completely disconnected and like an outcast and when I did a Working Holiday in Canada I made friends there. I literally am alll ALONE in the world. I have not found my place in the world. I have tried Suicide a couple of times cause of my circumstances. When I have had to fill in paper work that require a contact of next of kin and leave it blank they won't let me leave it blank and as I have nobody i just have make one up. I would NEVER talk to a "professional" if feeling Suicidal cause I know they do not care for the individual they just care about their agenda. I think it would be rather cruel to insist that I should keep existing as I have been till I die of cancer or some other horrible disease. Suffer and Suffer and Suffer. But Suicide is "Forbidden" "Anything but Suicide" is the motto.
Why do we need to fill our lives with stuff, entertainment, find a reason to live, find meaning in life etc? If Life truly was such a wonderful thing then Breathing only should be enough, being Conscious only should be enough and yet it isn't because Life in itself and just by itself is pointless and meaningless. It is up to each individual to find a meaning to it and give it a meaning and that varies from person to person. Some of us see that even if we fill it with temmporary pleasures like sex and stuff, tv, music, books etc that at the end of it all it is all still very pointless, it is just distracting us from the fact that there is nothing meaningful in simply just existing. I hate quotes like "Life is a Gift, that is why Today is called the Present. " Life is imposed and unlike a Gift it is not so easy to just give it away or get rid of it... How many of us if we could pick if to be born at all or not, having lived what we already have would choose to simply never be born? I am one of them. We are born into this Cult called Life of which we had no choice and if we ever announce that we prefer Death and want to die they lock us up for our own good so they say, to "save" us from ourselves, like cult members forcibly try to stop people from leaving their cult once they joined or are born into it. There are many different reasons why people feel suicidal, it is case by case. For some, things NEVER improve and will NEVER improve. I am one of those people for who this is true. Killing yourself is okay, it is like abortion, your body and your choice same with suicide. If my body and my life are not mine, then whose are they? Who does my Life and Body belong to? The Government? Society? I am fed up with all these Anti Suicide campaigns and these Anti Suicide Marches. All futile of course, Nobody is protesting in marches against Murder, they know it is ridiculous, how are you going to stop murder from happening ever? Same with Suicide, Suicide IS Self Murder. It all comes down to something called FREE WILL. I'm a good person so I feel a painless exit is warranted.
Hello. What is it that keeps you going? I resonate with your journey a lot. I know the place you are in. For some reason just ending it all doesn't make sense somehow and also committing suicide is a terrifying act in my mind, like drugs or drowning or hanging or slitting wrists or jumping in front of a train etc etc . Do you ever feel like you don't necessarily want to die you just don't want to live lie this anymore?
Depression is not a disease, is actually the empirical finding of much of psychiatric clinical research. A good summary of the evidence against the disease argument can be hearded here: https://www.youtube.com/watch?v=Ep1ODxCoYlI
I'm 25, I've had clinical depression for years now probably about 10 years. I hope I get out of it soon it fucking robs you of everything and molds your personality to that of nothing, fuck depression.
This is an extraordinary talk for the layperson. I loved the way he gave insights into the underlying biochemistry to finally include the psychiatric and psychological manifestations to create an unified understanding of the depression. Such talks should be adapted and given in schools, high-schools and universities to make people aware from young age about the devastating effects of this illness and about the how it can affect and sometimes shape ones life. Can be life savers!
Probably a service dog, to help a person with depression? Pets CAN be a lifesaver for a depressed person. BUT, they can also suffer the dire consequences of their owner's depression. A lady on the next block lost her partner to diabetes. She fell into a serious depression, stopped going out, started hoarding trash, cutting herself, neglected her pet finches. The super discovered her condition and her trash-filled apartment and called in adult services. She was hospitalized and put on the road to recovery. Unfortunately, her finches were dead on the floor of their cage. She just stopped taking care of them.
My husband and I were studying in London when we were young, and he starts to feel sad, lost his apettite and the sound of dried leaves on the streets made him cry. We are from a tropical country. The night comes to early in england, it is cold and cloudy in the autumn. The lack of sun made him depressed, he stopped to eat, sleep and during the night he start to have panic attacks.We came back to our country ealier although everything was paid.He starts to feel better in the first week. Sun is everything for him. I didn't feel the same, the lack of sun does not affect me. If I knew this, Í would have traveled in the summer, but I couldn't have imagined this would happen.
Have any depressed individuals tried the carnivore diet? It cured Jordan Peterson's depression (and his daughters too) and I want to know if it works for others as well.
If you're depressed and you're apprehensive about trying it, what do you have to lose?
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.