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Pharmacology - DRUGS FOR HYPERLIPIDEMIA (MADE EASY)

Оценок: 1842 | Просмотров: 131420
Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered include: basic pathophysiology of hyperlipidemia, lipids, cholesterol, triglycerides, phospholipids, bile acids, fatty acids, lipoproteins, apolipoproteins, chylomicrons, VLDL, LDL, HDL, lipoprotein lipase, atherosclerosis, vascular inflammation. Mechanism of action of antihyperlipidemic drugs and their side effects; HMG-CoA reductase inhibitors (statins), nicotinic acid, fibrates, bile acid sequestrants, cholesterol absorption inhibitor, pcsk9 inhibitors, omega 3 fatty acids. Drugs mentioned include; atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin, niacin, fenofibrate, gemfibrozil, colesevelam, colestipol, cholestyramine, ezetimibe, evolocumab, alirocumab, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), icosapent ethyl, fish oil.
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Текстовые комментарии (75)
John None (14 дней назад)
I found a great compilation of videos that should help on Pronto Therapy Folio
king sharma 143 (24 дня назад)
Bhai tu pdana chod de
xDomglmao (1 месяц назад)
Niacin leads to G6PD expression, would this by any helpful in a patient suffering from G6PDD?
Ралица Иванова (1 месяц назад)
This helped me a lot! Thanks!
zeel Kakadiya (2 месяца назад)
Thank you so much... This is amazing video...😍😍😍
HNR Elradawi (2 месяца назад)
Pråååteenz
Soumyadeep Dutta (2 месяца назад)
Thank you sir, your lectures are awesome!
Elaheh Habibi (2 месяца назад)
That’s amazing,thank you
Ranjith Jothi (3 месяца назад)
I always like ur videos sir.... We want more videos sir💓💓
Eull Light (3 месяца назад)
Y would someone dislike this!! Thanks alot
m.jawad Farooq (3 месяца назад)
thank you love from Pakistan
fastandeffective (4 месяца назад)
Lipid, cholesterol, statin, myths debunked by latest studies: www.bmj.com/content/361/bmj.k2243 bmjopen.bmj.com/content/6/6/e010401 www.ncbi.nlm.nih.gov/pubmed/28864332 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32252-3/fulltext http://www.dailymail.co.uk/health/article-5521767/Statins-hayfever-pills-fueling-antibiotic-resistance.html
mohammed aldaragi (4 месяца назад)
thanks to this amazing channel
zahraa zst (4 месяца назад)
Thank you so much
Adnan Shaikh (4 месяца назад)
Its getting harder,there are ads of about 19 minutes
Adnan Shaikh (4 месяца назад)
I just see full 3min advertisement for you bro, Please keep it up
Kathryn (5 месяцев назад)
Thank you very much for the effort. This really helps. This is really simplified for my report.
غازي ت ت ت (5 месяцев назад)
Thaaaaaaaaaaaaaaaaank yooooooooooooooooooou very muuuuuuuuuuuuuuch your mode of explain is very very very very fine
Сергей Русанов (5 месяцев назад)
Today there is a deadly error in medicine. Patients with acute heart attacks and strokes, as well as physicians therapists do not know important information. Because of this error, several million people die each year. Therapists and cardiologists are 100% sure that they are treating atherosclerosis. But this is a mistake. In the vessels of the heart and brain with acute disruption of blood circulation - there is no atherosclerotic plaque. The cause of an acute stroke and an acute infarction is a completely different cholesteric plaque. Soft, elastic, appears quickly (in a few days). A soft cholesterol plaque can be treated before surgery. Cholesterol cylindrical plaque easily disappears, easily stretches. What is Arteriosclerosis? https://en.wikipedia.org/wiki/Arteriosclerosis « Arteriosclerosis is the thickening, hardening and loss of elasticity of the walls of arteries...The lesions of arteriosclerosis begin as the intima (innermost layer of blood vessel wall) of the arterial wall start to fill up with the deposition of cellular wastes. As these start to mature, they can take different forms of arteriosclerosis. All are linked through common features such as the stiffening of arterial vessels, thickening of arterial walls and degenerative nature of the disease» wikipedia. https://en.wikipedia.org/wiki/Atherosclerosis «Atherogenesis is the developmental process of atheromatous plaques. It is characterized by a remodeling of arteries leading to subendothelial accumulation of fatty substances called plaques. The buildup of an atheromatous plaque is a slow process, developed over a period of several years through a complex series of cellular events occurring within the arterial wall and in response to a variety of local vascular circulating factors». wikipedia. What is what really is in the arteries? On the giving video we can see cholesteric cylindrical plaque of yellow color, which is elastic, has cylindrical form, which follows the contour of vessel, has approximately the same thickness all around and has the hole in the middle and blood passes through it. This plaque kills, makes people with disabilities, increases the level of bad cholesterol in the blood. - https://www.youtube.com/watch?v=ImHe-7RoqVc&t=4s 1:49- 3:06 - https://www.youtube.com/watch?v=fGw0oBmmuHM 0:27 , 2:06-2:15 - https://www.youtube.com/watch?v=CE2UMvOvWnU 2:04- 2:35 -https://www.youtube.com/watch?v=wQ1yIT8dt3Y-- --25:13- 25:46 cholesteric plaque - - https://www.youtube.com/watch?v=R8dVYf-LV44&feature=youtu.be 4:58, 13:51 - https://www.youtube.com/watch?v=yqx_19N6eWA&feature=youtu.be 1:52 -2:15 - https://www.youtube.com/watch?v=arZiYgt200M&feature=youtu.be 17:58- 20:23 - https://www.youtube.com/watch?v=5n3npP1a58E&feature=youtu.be 58:15, 59:22,1:11:44 - https://www.youtube.com/watch?v=Oa8XV27KNAY&feature=youtu.be, 00:54, 11:05 - https://www.youtube.com/watch?v=wYpyj97Jmxg&feature=youtu.be 0:47 - https://www.youtube.com/watch?v=tSdF6_1DGls&t=258s 4:10-4:20 - https://www.youtube.com/watch?v=hRBFnNl-SpU 1:09-3:19 Medical Hypotheses 106 (2017) 61–70 https://doi.org/10.1016/j.mehy.2017.07.001 In this article is given the new insight about the affection of stress on the increase of level of low density lipoproteins (LDL) in the blood, which is connected with the disturbance of hydrodynamics in the bloodstream, the attention was paid to the cylindrical cholesterol plaque, and it’s classification. The disturbance of hydrodynamics of blood under the stress leads to the formation of a cylindrical cholesterol plaque, which repeats the contour of the vessel, and leads to the ischemic disorders of the heart and brain. The cylindrical cholesterol plaque goes through several stages of development: friable, yielding, dense, old. In the case of destruction of friable, fresh cholesterol plaque, releases a big quantity of lowdensity lipoproteins. This leads to the pathological increase of level of LDL in the blood. In the case of long disturbance of hydrodynamics, occurs the formation of strong links between low-density lipoproteins. Yielding cholesterol plaque is formed. Further maturation of cylindrical cholesterol plaque, leads to it’s densifying and damage. We may emphasize, that short periods of strong contraction and expansion of vessels lead to the increase of level of LDL in the blood. Self-dependent restoration of normal level of LDL in blood occurs in the case of restoration of pressure in the limits of numbers, which are specific for particular person, and which don’t exceed the physiological standard. Among patients with long duration of stress, the duration of vasospasm increases. LDL, without having a possibility to crumble, begin to stick together and form the yielding cylindrical plaque. It is characterized by having of not so strong connection with the vascular wall, and maintains only at the expanse of iteration of the vascular wall, it has cylindrical shape, is elastic and yellow. The thickness and length of walls depends on the degree of cross-clamping during the time of formation of yielding cylindrical plaque. In the case of stopping of spasm, yielding cylindrical plaque can resolve slowly. Among hypotensive and individuals, which have normal pressure, the increase of level of LDL isn’t noted. There aren’t such investigations, where such link was noted. The increasing of level of LDL among these people (especially under the stress) can say about cases of short-term increase of pressure, which could be unnoticed. These patients require pressure monitoring and, accordingly, the adjustment of the state of stress and anger. Youtube: Atherosclerosis? No!!! Cylindrical cholesterol plaque!!! Pathophysiology https://www.youtube.com/watch?v=MIfAVTDvM2o The proposed hypothesis more fully reflects the mechanism of abnormal increase of level of LDL in the blood. Were disclosed cause-effect relations between stress, short-term increase of pressure and an increase of level of LDL in the blood; between stress and ischemic disorders in heart and brain. Was described the mechanism of formation and stages of development of cylindrical plaque (CP). Was given an explanation for the reasons of increasing of the level of LDL among hypertensives, who are on the strict diet without cholesterol. Was explained the absence of increasing of the level of LDL among hypotensives, who take large amount of food with cholesterol. Natural restoration of level of LDL in the limits of PS can only be achieved under certain conditions: the full restoration of the work of the central nervous system and autonomic nervous system, the reduction and complete ceasing of stress and restoration of pressure, which mustn’t be above the physiological standard.
nagarjun Gagrai (5 месяцев назад)
Fabulous
Princess Rhenette Cedeño (6 месяцев назад)
Is the action of phytosterol in lowering LDL is the same in the mechanism of action of Ezetimibe?
xDomglmao (1 месяц назад)
And, is it the same mech.? :D Don't want to read the whole paper if you did alrdy :)
Princess Rhenette Cedeño (6 месяцев назад)
+Speed Pharmacology Thank you so much. This is a big help. You're such a great person. 👍
Speed Pharmacology (6 месяцев назад)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503415/
Pharmacist 6609 (6 месяцев назад)
Thanku Sir... Sir Plz make a video on CHF and Asthma...
naveed ali (6 месяцев назад)
Fazol
Rahul Swami (7 месяцев назад)
What is flashing caused by niacin?
Garima Singh (7 месяцев назад)
Thnku so much
aida al-oatti (7 месяцев назад)
thank you sir!
Dev Kumar (8 месяцев назад)
Great job sir very nice👍👍👍
Taha Nayyar (8 месяцев назад)
If i pass tomorrow i am gona name my kids after your channel
Catalin Voegel (15 дней назад)
I can across an awesome collection of videos that may help you at Pronto Therapy Folio
xDomglmao (1 месяц назад)
Did you name your kids "Speed" yet? :D
Adnan Shaikh (4 месяца назад)
Taha Nayyar lol, So...do you passed?😜
Mawadda shaban (10 месяцев назад)
That is amazing !
Supriya M (10 месяцев назад)
Can u please make a video on Cardiac glycosides.
ZIPHO MADOLWANA (11 месяцев назад)
The best
bshayerahmad (11 месяцев назад)
thank you so much this is very helpful
Temi Wright (11 месяцев назад)
ANTIBIOTICS VIDEO PLEASE... THANKS ALOT
Zade Batarseh (11 месяцев назад)
Thank you! 2hr lecture in class summed up 1000x better in less than 15 min!
Anjali Kumari (11 месяцев назад)
This is so amazing so handy in short perfect to the point explanations. The effort is fully appreciated, Sir. Thanks.
Krishna Hanchate (11 месяцев назад)
Please a video on pharmacology of asthma🙏🙏 or reply a link having a good video on it
hawraa mahdi (11 месяцев назад)
Thank youuuuu soo much ..🙆 just another amazing work .. Keep hard working ...you r simply great 😢😌👏💛
M. Ameer (1 год назад)
This video is awesome! now I love pharmacology beacuse of you! thanks
Bitkigibi Yetistirdi (1 год назад)
PS: GOD BLESS YOU 🙏🏻
Bitkigibi Yetistirdi (1 год назад)
YOU ARE WONDERFULL SIR!!! FINALLY I UNDERSTAND PHARMACOLOGY BECAUSE OF YOUR VİDEOS. PLEASE YOU BECOME MY TEACHER IN MED SCHOOL.
Fatemah Eldeeb (1 год назад)
Excellent video! Please keep them coming.
Karim & Marianne Mikhail (1 год назад)
Excellent!!!!
Sachin (1 год назад)
gold!
surumi bp (1 год назад)
thank u so much sir....plz post antibiotic and anticancer drugs video sir
Rahul Tiwari (1 год назад)
Great lecture sir... Plz keep posting new topics. Thanks alott sir
Shelly Lynn (1 год назад)
Your videos are so clear, straight forward, and thorough! Thank you! Please make more!
João César (1 год назад)
Love you man S2
Sara 90 (1 год назад)
thank u this video was amazing
Nousheen Rashid (1 год назад)
very very excellent
Muhammad Usman (1 год назад)
sir your videos are amazing and easy to understand wounder-full. sir when you are providing lecture on ANTI HISTAMINES,,???
Sapana Yonghang (1 год назад)
Your every videos are amazing! I have gone through each of them! You should make more of these! :)
Sanjana Jadhav (1 год назад)
can u upload videos of chemotherapy drugs ?
Reu P (1 год назад)
Thank you so much!
Said Gitta (1 год назад)
Superb pharmacology lectures.Thanks a million
mhmd fadoul (1 год назад)
thanks for this interesting lesson. would you talk about contraceptives
medi medico (1 год назад)
please do more videos regarding pharmacology
Seema Firdous (1 год назад)
you are amazing!!!
Sharif Khan (1 год назад)
thank u for help that video
Ginu John (1 год назад)
sir can u make a video on drugs affecting blood please
Ada Ndriollari (1 год назад)
Thane you very much from italy !!!
Shahran Sabah (1 год назад)
Thanks a lot but could you make video about anticancers
rian x (1 год назад)
I'm studying dentistry and this is extremely helpful for learning patients' medications which aren't taught well in school. I really appreciate your work, please keep up the great job.
Heba Abd El Samie (1 год назад)
can you make video on drug for epilepsy and NSAID Iam waiting for you so amazing video but please hurry soon I will have exam and I really appreciate your help
AHMED N (1 год назад)
good explanation. thanks
Mina dz (1 год назад)
this came just in time. . i have a pharmacology exam tomorrow and this video saved me so much time. . thanks a lot!
Nouf Alf (1 год назад)
Ohhh man I wish you put this up. A week ago 😭💔
ninou norino (1 год назад)
thank you very much
DR mubasher (1 год назад)
👍🏻👍🏻✌🏻very fantastic
Nicholas Lem (1 год назад)
Thank you so much...You are amazing...I really love your videos...You really make things easier to understand....Thanks to you i got an A this semester...Thanks man

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