Bupropion is an antidepressant and a smoking cessation aid. The drug has been tested in many other conditions, including ADHD, obesity, and seasonal affective disorder.
It has multiple pharmacological mechanisms and it's still not entirely clear how bupropion works.
Some recreational use has been reported, though the substance usually isn't very pleasant and it can be dangerous.
Overview Page (Including References): https://thedrugclassroom.com/video/bupropion/
Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/5mecyb/bupropion/
Bupropion = Amfebutamone; Wellbutrin; Zyban; Quomen; Zyntabac; Budeprion
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Please remember everyone, every drug affects every body differently.
This drug in addition to my SSRI's have been very effective for me, however as some comments here show this drug only made them feel worse than before. But please, if you've had a bad experience with this drug, don't demonize it and call it a bad chemical, because it is one of the best antidepressants out there and has helped many people immensely.
If you are thinking of trying this drug for your treatment, don't be shyed away by people's horror stories, because chances are you won't have the same experience as them.
works for me along with valium and gabapentin. does increase my anxiety thou, wouldn't be able to take it without the valium and gaba. good for people who eat out of boredom, probably why it helps people stop smoking? also I live in the u.p. where we get shit weather 6-8 months out of the year it does work for s.a.d. definitely better than ssri's which are garbage.
I should ad I am on 150mg Sr 1-2x/day some days I don't take it at all, this weather has me back on 2x/day. it does work for concentration. I responded horribly to the xr version, made me feel like I was crashing all the time.
Would there be any negative effects for someone to take this while recovering from years of meth use? Would it harm their recovery or would it be unhealthy to start while the brain recovers? Severe anhedonia is present.
I would seriously consider trying it for your recovery. It's been studied but results have been inconsistent, unfortunately. I believe it may very well assist recovery but not in every case which is mostly the case. Try NAC also, n - acetyl cysteine it's looking promising in studies.
I take bupropion for my depression and ADD. At first I took 150mg and the first week was horrible. I was maybe even more depressed than before but because my doctor told me that could happen and it would only last 1 week maximum I knew I wouldn't feel like that forever. After the first week I didn't notice much difference before I was taking bupropion. My doctor upped the dosis to 300mg and immediately after taking it the first time I felt like a whole different person. I can even sit still and focus on my work now and I feel better than I have in a long time.
I also smoke weed to help me sleep and I had no bad experiences with it so far.
I've been on 300mg for 2 and a half years. I was on celexa only for a long time before I finally added Bupropion. When I was on only celexa I would often get strong waves of depression and hopelessness. I was emotionally unstable and felt drained all the time. I was definitely lacking something in my brain and when I started taking Bupropion it felt like it replenished whatever I was missing. It took away the overbearing waves of emotional pain that used to overcome me all the time. That being said, although I consider it a huge help, I still get depressed sometimes but I've been able to pull myself out way easier ever since taking Bupropion I've never experienced any side effects other than dry mouth. I sleep fine but then again I've always struggled with chronic fatigue. I don't know if Bupropion made a huge difference in that regard but maybe that's because I'm just a naturally low energy person.
I've been on it for about three years and it's been good. The reason I'm stopping is because the tinnitus is getting so bad I cannot stand it. After going through a battery of hearing tests, bupropion side effects was ruled the cause. Sadly everything has a trade off.
This is the best antidepressant I've been prescribed and I take it with a mood stabilizer (Lamictal) because I was also diagnosed Bipolar 2... I have had major depression and Lamictal helped that also. Whenever I've tried other antidepressants they have made me feel weird or 'manic' irritable etc.
My will power allowed me to quit smoking the 2nd day of taking Bupropion! I still get the cravings but I immediately put my focus on something else. I'm on my 5th day smoke free! My daughter is extremely happy. God is good!
Since I have been discharged from mental hospital I am facing problem of fatigue/strain, feeling like layer covered the whole brain, less energy in brain cells, no capacity to workout/duties, insomnia. To whomsoever psychiatrist I have consulted they are prescribing antidepressants/antipsychotic (escitalopram, etizolam,sodium valproate, bupropion,zolpidem,etc.). Is this the only way to overcome such problems? is there any psychiatrist to answer me for this?
These medications are subjective. Wellbutrin is probably the most benign antidepressants and effective and easy to discontinue if chosen. It can cause insomnia but if you dose early in the day and gradually increase it over time that can be avoided. Most comment that are negative I'm assuming expect a magic wand. Also expect results right away. Depression is work and medication is a small part of working out of it. Also taking medical advice from a stranger off YouTube kind of indicates your crazy. Personally Wellbutrin , and tried em all, was the one that gave me a proactive push. One I truly don't like is Effexor . Getting off it is truly awful. Think you were depressed before, that i.m.o. is poison. BUT everyone is wired differently. Everyone has different types depression. Nobody has the power to get you out of depression but you. It's a job. You want it done to your satisfaction then do it, the experience will be a skill set that serves you well. Also not every depressive episode is the same so if you feel yourself slipping into something know it's not a repetition of the last or the worse.
I'm prescribed effexor and was given Bupropion to.. Ummm.. Help the effexor I guess? Anyway I agree about effexor. I get terribly irritable and experience brain zaps if I miss a couple doses of that shit. Haven't been on the Bupropion long enough to experience any good or bad effects yet.
I keep hearing opposite opinions about taking Bupropion while smoking weed. Is it safe to do? I was prescribed Bupropion as an anti-depressant and stopped taking it after the first couple days due to increased anxiety but I want to try using it again to see if it works. I haven't gone to get a new prescription yet so I'm currently still prescribed it and have some and wanted to try it again today.
It's a stimulant. If you snort one....it will burn the fuckbout of your whole face and nosd. But it is like taking a hit of cocaine.. that being said, I'd you do it, you just might have a seizure or worse. Don't do it. I did my whole script. One night.... i destroyed my apartment and tried to kill myself by taking 38 Clonazepam
same thing i am taking 150mg of Wellbutrin extended release there big pink round pilld with a E on front and 1111 on the back they also give me ear ringing like somebody lit a firecracker next to my ear for like 5 seconds it also makes me paranoid and talk fast especially when i drink a few rockstar energy drinks or hot coffee i can start wigging out i have to tell my brain to relax i been on it almost 2 weeks hope it gets better i have depression
Seizures are usually connected to GABA receptors... like Benzodiazepine Withdrawal can cause.
Ooh so I just hit the part ,, I keep forgetting how detailed this guy is....
So in the high dose GABA must be affected indirectly?
When I ate an edible while I was taking this... i entered several dimensions. WARNING DO NOT INTAKE OR SMOKE MARIJUANA WITH THIS DRUG!!! You will have Major Panic Attacks and Potentially unlock schizophrenia
I have to disagree because I've smoked weed for several years now and recently began wellbutrin and lexapro about half a year ago, and I've been smoking bud the whole time and had no noticeable difference. In fact I've been particularly LESS anxious than ever before, even while high. Drug interactions affect every body differently and mixing these two must not go over well with your body and brain.
Wellbutrin XL is the best anti-depressant for me. I take it first thing in the morning and it lifts my mood and energy without any negative side effects. I can’t tell I’ve even taken it, other than the fact that my energy is higher. I did lose my appetite (and about 10 lbs in the first 4 months) when I first started taking it but that effect has gradually decreased and now my appetite has fully returned. I quit smoking almost immediately upon beginning Wellbutrin since it made it impossible for me to get a nicotine high, so smoking was just frustrating and gross. Just 25 mg of Zoloft had me hallucinating and blacking out within 3 days (probably a severe adverse reaction) so if anyone else is having issues with SSRI’s, I’d definitely suggest trying bupropion. Umm but don’t snort it? 🤦♀️ Thanks for this video. I was curious how the drug worked.
I've been on Adderall 30mg XR for a while and am about to start taking Wellbutrin 150mg and was wondering how they may interact. Also wondering if the Wellbutrin will interact with my Effexor or Mirtazepine. Thanks.
I can only speak from my experience I have taken Effexor ,Mirtazipine and wellbutrin .I didnt feel any negatives There is a warning when I checked for interactions it says Effexor XR oral + bupropion HCl oral Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed Effexor XR oral increases toxicity of bupropion HCl oral by unspecified interaction mechanism Additional Information: Keep bupropion dose as low as possible as seizures may occur.
On 300mg for years until it caused me issues.
My positives- greater metabolism that equaled weight loss.
More sex drive.
My negatives- some forgetfulness. Caused imcreasesd anger output, without depression.
After long term use raised bp to high levels, ringing in ears, stroke like symptoms came on due to higher bp.
Went off cold turkey after the bp rise =numbness tingling on one side of body. High bp stoped after going off, and stroke symptoms also. Sypmtoms of weight gain after going off but not more caloric intake and same workouts. It messes with your metabolism its like a speed, increases adrenaline.. ( anger output, sex drive, energy) Sped up bp, sped up metabolism. Great for short term use horrible effects long term with higher doses on your health. Its like taking speed every day for years. Not good for your body. Drs will only sing its praises though.
I was on Wellbutrin in highschool and I hated it. My psychiatrist wouldn't listen to my feedback and kept upping my dose over the years until he couldn't anymore. I kept asking to try a different drug, but he insisted. I was also taking trazodone with it, which kept increasing as well. After about a year I quit it all together without telling him. When he found out he was very upset. He had warned me before that it was dangerous to do so. A few years later I was diagnosed with sinus tachycardia. My symptoms started around the same time I quit taking my prescriptions. I wonder if my reckless decision back then had a negative affect on my heart. I see that one symptom is tachycardia.
Rarely enjoyment! Thats a laugh.I personally have experienced it's recreational use. I was using so much that I don't even remember or know how much. It gives a brief euphoric feeling then you will have so much energy and focus. I can finally get up and get my house clean. I also can finally focus on any task. The draw back? Now I can't function with out it.
ADD. I couldn't make a driver's licence done. Bupropion was like wearing glasses. Total, magical improvement in concentration and working memory. However: Intensive feeling of anger, not like irritation but just clear agressive mood. It goes down with time. It's 6th week now.
Fuck Bupropion. I was prescribed this shit a few years ago and took it trusting the doc. This shit fucking tranquilized me all Summer that year. I spent that whole summer basically sitting out back on the porch in a chair and not wanting to do anything most times. I really couldn't even be bothered to do the easiest things, like going to the post office to get my mail, or going shopping, or even going to get gas uptown in my truck. Horrible. Fuck that.
+ANGEL NAVARRO you are so nice and warm to me...I will burn myself with healthy food, running, positive thinking, perfectionism...I think I have to put to much energy to just pretend to be normal...and my emphaty knoks me downs inside...so happy for you...yes I think paxil and paroxat are the same..I can feel some improvement In socializing but feeling real ok is just a thought...and yes I can imitate it...but just imitate it...thanks
I just was put on this medication for Seasonal affective disorder, ADHD and to help curve my cravings from food and the negative effects of my binge eating disorder from BPD. I am now on 150mg Rx. Only side effect I have is dry mouth.
Most of my family members are also on this medication for depression, and
Seasonal affective disorder.
why is it bad when taking tramadol?
i was on an SSRI and tramadol, i was getting headaches once in a while during sex or any strong physical activity but i felt good. i felt more like myself, with more energy and focus.
My psychiatrist switched it to Bupropion XL. first month i got 150mg daily, i felt tired all the time, sad, and just not good. she upped it to 300mg, i still feel tired and just not good.
i wanna ask her to switch me back to SSRI cuz i cant stand this medication :/ even if i have to give up tramadol. i would give up tramadol in a heart beat. ill rather be in pain and happy than still be in pain but now im sad and tired all the time...
anyone else feel tired, twichy, foggyness, no motivation.. etc with bupropion/ Wellbutrin ?
That's funny you mention the smoking cessation, I knew it had those affects. I started taking Bupropion (300 mg) a little over a month ago and I needed to quit smoking because of surgery coming up and one day I just decided I wasn't going to smoke and it came so natural that it shocked me.
I just hit 4 weeks not smoking today (11/8/17) and I feel so much better and I still can't believe that I quit cold turkey so easily. My mood is much higher and I'm no longer depressed. I haven't felt so free from my own mind for many years. Zoloft never did this for me. Although I am more emotional, I cry easier but then I usually laugh because what I'm crying over is literally nothing to cry over. XD Anyway thanks for the video!!
I've been on Wellbutrin for about a month now. The first couple of weeks were marked with terrible insomnia. I could fall asleep, but I wouldn't stay asleep. Also good to note, I work night shift so I had to switch up the times I would take it. ALSO... I run on caffeine.. or at least I used to. A combination of Wellbutrin and coffee would give me major palpitations and tachycardia. Once I cut the caffeine down, those symptoms drastically decreased.
The major positive that I can notice thus far is that it definitely increases my energy and ability to focus. I've gotten so much more stuff done and have increased my ability to focus on tasks much more effectively. Prior to this, my depression left it hard to get up off the couch to do anything other than the essentials (i.e. go to work, eat, do laundry when it was overflowing). Now I find myself looking for things to do.
DO NOT TAKE THIS BEFORE GOING TO SLEEP. I typically take it about a half hour after I wake up. I work night shift so I take it at 5pm and then 6 hours later (I work 12 hour shifts). This seems to be the best for me. You'll have to mix it around and see what exactly works for you.
Also, I've seen other videos where it says that your have decreased alcohol tolerance. YOU SHOULD NOT BE DRINKING WHILE TAKING WELLBUTRIN. It is contraindication completely and can cause an increase in seizure activity.
It is honestly hard to tell if it's affected my depression. My anxiety is a bit worse on this but nothing that I feel I can't manage. What has really helped is therapy. TO NOTE: I began therapy 3 months before going on any antidepressant. So this has been supplemental to that. I feel that worked the best for me.
tesresterone should help get tested and dopamine in wellburton should get you motivated that's what I might do as other antidepressants deffinitlt cause erectile dysfunction commonly known as hard on and it stops you from ejeculating serious if you have a girlfriend or wife steroids and wallbuton sounds good
I would like to know more about drug interactions with this stuff. Im starting taking them tomorrow, and I told the doctor about my lack of general motivation and proneness to anxiety. I wanted ritalin to those times when i am down and alprazolam to any anxiety related emergency i may have. He thought bupropion was the best alternative. but i didnt mentioned i had used cocaine ocasionally and very mildly (very few small lines), and have the intention to use psychedelics such as psilocybin and mescaline (I dont use much alcohol at all). Never felt confortable to say that to a doc. What do you think? May I have super vigillant to what substance I use or is less of a problem?
If you are prone to anxiety Buprupion will exacerbate it..IMO Its not advisable to add psilocybin and mescaline to the mix.Welbutrin anxiety is magnified by psychedelics and results in an increased risk of negative trips
I took this when I was younger and how no side effects what so ever. I started taking it again, and had 2 grand mal seizures. This must mean I have a short seizure threshold which I read affects 1 in 1000 patients. So you just never know when a medication is going to turn on you.
Bupropion is typically contraindicated with methylphenidate and the combination is avoided. Though there are cases where they're used together depending on the patient, so it's best to bring it up to your prescriber.
Some people say it gives an incredible rush when injected but otherwise it's pretty poor recreationally. And it also is very bad for the veins. I just got precribed this along with lamotrigine but I'll stick to medical use.
@The Drug Classroom - I became highly dependent on Wellbutrin while in rehab. I would cheek the pills and crush them and snort them. The effect is exactly like a mild cocaine high. Interestingly, it also has local anesthetic effects on the nasal mucous membranes when snorted, just like cocaine.
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.