4 principal tenets that may undermine your current understanding of the efficacy and safety of antidepressant medication. Visit my website to download a free copy of my "7 Therapeutic Foods PDF" http://kellybroganmd.com or signup for my my newsletter now here http://eepurl.com/Pyw11
The truth is...nobody knows for sure what causes depression. What we do know however is that SSRIs DO HELP people feel better short and long-term. And SSRIs also help sufferers of PTSD, mood disorders, and obsessive disorders to feel better. I respect her level of education, but I would steer clear of her suggestions until we know the root cause of depression for certain.
hah asoon as my gf started taking those. she took off partying and just had this over the top feel good attitude, but she avoided me at all costs, almost like the pill boosted her ego times 1000, then she dumped me and suddenly didnt love me anymore or have any feelings or emotions. we were going to get married and planning another baby and built our lives together, she then replaced me with her friend (female) and said that shes her family now. i blame the drugs , ive known her for 8 years and this behavoir came out of no where, right after those antidepressants
I’m not sure about this because I can clearly tell the medication does have real physical effects on me and also side effects. On escitalopram I felt it made me unnaturally positive and energetic, and I know the difference between what is normal and what isn’t.
I was suffering from severe depression caused by opiate withdrawal. My psychiatrist prescribe me cymbalta. Within one week I was starting to feel good again and within two weeks I was feeling amazing. Are you saying that was all placebo effect and nothing to do with cymbalta?
honestly, I did feel a bit lost while hearing this.
I highly think that setting up a one on one meeting for you to better explain would help wonders! Preferably by a candlelit dinner.
My dire mental health gravely depends on it😁
hi..had a bout with depression/antidepressants where a alternative..did not work..moved on/// ended up cultivating a new life style from diet to social/....one postive thing lead to another.... everything in between..,this whole journey changed my life..for the better... actually had a friend stay the antidepressant route with a bout of his on with depression...20 yrs he never felt emotionaly stable..constent blood work and ajustment on meds...organ failure 2013 he passed away...thanks kelly brogan md..you are true. rip stevie V.loved you budd....always joey.
Good luck on finding actual root causes. Patients who are depressed and have tried every antidepressant that exists should be able to get treatment with tramadol, morphine, or buprenorphine, at least they actually do something
As a licensed therapist, I agree with Dr. Brogan. People need to be educated on how medication and mental health works. I always say medications are not "magic pills" To become mentally healthy you need to have a healthy, stable environment, eat decently, move your body and have some supportive and caring people in your life. Many people with severe mental health symptoms, such as Schizophrenia have a history of trauma. Medication has it's place but it is not a cure.
This lady has no clue what she is talking about. I'm assuming she has never had personal issues with chronic mental illness because there comes a point when you can have a perfect lifestyle(eating, working out, etc.) But chemical imbalances remain. This is when medication is extremely helpful.
I tried anxiolytics and antidepressants that my doctors prescribed me for my mental issues. All they did for me was decrease my libido and make me feel nauseous. Medications don’t work, psych wards don’t help. Fuck coercive psychiatry, fuck pharmaceuticals, and fuck the exploitation—I mean, “healthcare”—system. Change your environment and lifestyle, don’t trust these frauds calling themselves doctors and pretending to be healers. You’re a moron if you believe they want you to get better.
I will not drink this Kool Aid. Started watching the bi polar lady who somehow was taking meds. went off them and this just doesn’t add up. This is actually extremely dangerous because medication can keep people out of hospitals. Oh and by the way I was so depressed that I literally almost died. Medication and ect saved my life. I have been dealing with bi polar disorder since I was a teen. The highs and lows are absolutely real. I am appalled at what this so called doctor is promoting. # This is why stigma exists. # Stay Strong
totally strange that over the years Various doctors have told me that I suffer from depression and when I take the bloody things I go crazy to the point of feeling I'm going insane. I took the liberty of taking myself off these poisons and recovering . I told my doctor ! big ,big mistake, He threatened to send me to a mental ward for assessment, I accepted. Told that there was nothing wrong with me , I now have a new doctor, who tried to put me on antidepressants. I told him that I would not be taking them and that the only reason he thought I was depressed is because I am totally shit off with the medical profession.
No psychiatrists measure or scan their patients' brain/chemical structure. They will all just tell you that no formal techniques exist to measure individual brains, so right there and then it should be clear that it's a pseudo science with only general guidelines based on clinical trials and general hypotheses (DHM-5).
Actually i left my medication, venlor xr, but there was some sudden shock like electricity in my mind like seziurs. I was tolerating this for 10 days but this was not cover-up my mind. Then i recently took it again. Now i am fine but i really want help from your side. It really help
I am totally frustrated.
Thank you doctor for this. I only wish the P.A. who prescribed Prozac to me would have seen this. Now I'm suffering after being discharged and am no better then before. I Was d-c because when I reported my side effects and she wanted to put me on a more powerful a/d and I said no she got mad and had a fit. Life sucks because I asked for help and instead was turned into something evil - an addict.
This women is my hero. She is actually looking for a root cause using interventions that are natural to the body. Unfortunately, this message will only be accepted when ppl realize that long term use of any drug will not solve the underlying condition. Ppl only want quick fixes rather than lifestyle changes.
Modern psychiatric medications, are based on the 'chemical imbalance' theory. It's never been verified scientifically, nor does science support it.
It's profitable for the pharmaceutical industry, which 'fixes' it. It's also easy to sell. The solution is to 'regulate' the chemicals, which these medications don't regulate efficienctly, nor is it necessary.
From my experience depression is due to unresolved issues, I no longer suffer from depression and never took any meds. In my honest opinion meds just treat the symptoms, not the cause! That crap will turn folks into zombies!
I’m a healthy (blood work, Body and mind) raw-vegan who works out daily, does meditation and is happily married and I love my job. Yet, without my anxiety medication- I am unable to do a lot in a calm state of mind.
So screw this kind of limited thinking.
Furthermore, lest u have experienced the depth of Hell anxiety and depression can create, Why on EARTH would u suggest, so simply, the placebo affect. I am speaking from direct and brutalizing experience. I know the guteral, spine twisting pain. I also know, after 2-3 weeks on Lexapro, I began to see the Sun again. NOT plugging any specific SSRI, just sharing my very personal and real experience with the devil's disease. One that was essentially eradicated from proper medication. Don't be so glib.
I'm so sorry that u are a "licensed professional" regarding mental and social health. The words coming out of your mouth are not only irresponsible, but, down right dangerous. There are TONS of socialistic and scientific studies PROVING the benefits that there of an SSRI. I'm terrified for the fear and doubt u may be putting into your patients, who quite possibly could benefit from anything. Possibly even a placebo affect. Sometimes u just need to think/know that there IS HELP. Don't allow your degree to write a check your BRAIN can't cash.
Wow....this is quite a statement Madame. However, I do not share your views. Are you a Neurological Biochemist? I would venture...not. Your advice is half baked and dangerous. Placebos have there place yes...but the mind, like the Universe...is still a mystery. Many people are greatly helped by GABA and SSRI...... you do many a disservice by voicing this opinion.
These three have helped me fastest to alleviate depression when I’ve had it:
1. Being understood when talking about my feelings.
2. CBD oil.
3. The Wim Hof Method.
These have helped a lot:
2. A healthy diet which fits me.
3. Cold and hot water exposure back and forth.
4. Meditation and mindfulness.
6. The company of good people.
7. Doing things I love.
There will be people that get mad at this because you're basically saying "they've been lying to you", but grieving is a crucial step in letting go of the myths. Thank you so much for this video. All I wish I could do was explain these things to people already medicated in a way that they could understand and not immediately give me attitude and start protecting their beloved meds that cure chemical deficiency. These meds should be a way of smoothing out the healing process, they shouldn't be meant to solve your issues or mask them.
I found your opinion interesting until you likened antidepressants to placebos. This is has been proven otherwise by peer-reviewed studies and while you may have a hypothesis, you can’t just spout it off and disregard others when real people are benefitting from antidepressants. That said, I think that counselling is a better first line of defence than pharmaceuticals.
Truth is..it's all guesswork..some things work for some people and not others...i've personally seen a bunch of people come off antidepressants and work out and eat properly say they have never felt better and having heard from people that antipsychotics don't work yet my father was on them and I can tell you that as flawed as they may be,they helped a lot...
i never said it does , do you read what i type?
for the thousandth time: i dont advocate for anyone to use antidepressants nor do i say that they are supposed to be taken
im saying that for a small fraction of people they work and that the effects of that is NOT placebo and some people would not have survived without them. it masks the depressive symptoms out of the inflammation they have but that is NOT a solution and should NOT be done but instead one should focus entirely on diet and the reducing of the chronic low grade inflammation, but a lot of people do not know of this and the people prescribing you antidepressants wont mention any of it
it seems like youre stuck with this mindset of attacking psychotherapists but thats irrelevant here as i dont agree with their methods in most cases
Prunk Doo Antidepressants do not fix inflammation as you claim. They damage and disrupt normal brain function leading to unawareness of symptoms. Using antidepressants or any psychiatric drugs does not get to the root cause.
If the cause is inflammation as you claim then it would not be a mental illness it would be a disease and antidepressants would not be used. As i told you a million times, psychiatrists do not cure or stop the progression of disease they create it and create mental illness for profit.
because they work for some and conventional medicine has the habit of hiding and hiding symptoms instead of curing the root cause of the illness.
"Cytokines induce depressive symptoms by influencing diverse mood-related processes. Elevated inflammatory signaling dysregulates neurotransmitter metabolism, impairs neuronal health, and alters neural activity in mood-relevant brain regions (2, 19).
Peripherally released cytokines send signals via molecular, cellular, and neural routes, which ultimately reach the brain and enhance CNS inflammation (2, 19, 20). Cytokines alter production, metabolism, and transport of neurotransmitters that synergistically affect mood, including dopamine, glutamate, and serotonin (21). For example, cytokines stimulate indoleamine 2,3-dioxygenase, an enzyme that affects tryptophan metabolism. This well-established pathway promotes depression by simultaneously slowing serotonin production and enhancing levels of kynurenine, a tryptophan metabolite (22).
Inflammation also affects neuronal growth and survival. Cytokines contribute to oxidative stress, which damages glial cells in mood-relevant brain regions, such as the prefrontal cortex and the amygdala (23). Cytokine-induced glutamate dysregulation can lead to excitotoxicity, thereby decreasing production of neurotrophic factors (e.g., brain-derived neurotrophic factor, BDNF) that typically support neuronal health, neuroplasticity, and neurogenesis (24). Notably, these neurotransmitter and cellular changes alter brain activity and neurocircuits underlying distress, motivation, and motor function (16, 19).
In addition to their effects on neural processes, cytokines promote dysregulated hypothalamic-pituitary-adrenal (HPA) axis functioning, a key characteristic of depression (25, 26). Abnormal glucocorticoid signaling can influence the maintenance and progression of depression (27). Briefly, glucocorticoids typically dampen inflammation via a negative feedback loop. However, inflammation can cause glucocorticoid resistance in immunocytes and their cellular targets by inducing MAP kinases c-jun N-terminal kinase (JNK) and p38 (1). In this way, cytokine signal transduction pathways (e.g., nuclear factor-kB, NF-kB) disrupt glucocorticoid receptor function and expression, leading to unrestrained inflammatory responses that could further fuel depressive symptoms (2, 26, 28). Cytokine-dependent glucocorticoid receptor resistance decreases inhibitory feedback on production of corticotropin-releasing hormone and cytokines, intensifying the stress-response system (29). The glucocorticoid receptor protein is abundantly expressed throughout the main neuronal subregions of the hippocampus. BDNF functions as a powerful modulator of structural plasticity in the hippocampus and mediates protective influences by enhancing neuronal survival (30). Sustained glucocorticoid exposure leads to dendritic atrophy in hippocampal subfields and decreases neuronal cell survival by evoking a decline in BDNF expression in hippocampal and cortical regions (31, 32).
Inflammation may affect people differently, depending on their individual physiology; some people have bodily systems that protect them from developing inflammation-based depression, while others do not. Mechanistically, even lower levels of inflammation could be depressogenic in vulnerable individuals; Raison and Miller (14) call this phenomenon “immune response element amplification.” These may include lower parasympathetic activity, poorer sensitivity to glucocorticoid inhibitory feedback, lower BDNF production, larger responses to social threat in the anterior cingulate cortex or amygdala, and smaller hippocampal volume. Indeed, these are all correlates of major depression that would influence sensitivity to the depressogenic consequences of inflammatory stimuli."
I never believed it either, in fact I believe a lot of these medications cause mental disorders. I have been on and off these types of drugs throughout my life and find that it makes me more depressed, anxious and have rage as well. My depression is situational and not a defficiency. It is caused by the fact that I am a care giver of someone who is both physically and mentally disabled and the stress my body started to attack itself and now I have an autoimmune disease that causes me a lot of pain. That makes me depressed not a seratonin decrease. I can't do the things I use to do and that would depress anybody. So I agree with you entirely doctor. :)
The diagnosis on depression needs to get multidimensional.
Meaning that other aspects that are associable should be included.
Not limited to the amount of close friends, sleeping in hours per day, how much sun light they get, exercise and diet.
Furthermore hypnotherapy is way more effective than medication.
The approach of this treatment is psychologically based, meaning that it is unavailable to test it double blind
She makes a valid point about the body's natural inclination to adapt in order to reprogram itself to a new normal when exogenous substances/drugs are introduced. It happens with benzos (down regulating of GABA receptors), blood pressure meds, opioids, etc., your body will eventually "adapt" to the these medications. If you want to mitigate symptoms of depression embark on a rigorous exercise program. Get up early 5X a week and do some walking/run/sprinting intervals; you'll feel better in a about a month.
THE BEST TREATMENT IS WEED. FUC ALL THESE DOCTORS AND PSYCHIATRIST AND WHATEVER THE FUC THEY ARE CALLED. MARIJUANA IS A HERBAL PLANT AND IS NOT A CHEMICAL DRUG. GOD PUT MARIJUANA ON THIS EARTH FOR US. MARIJUANA IS THE CURE!!!!
I'm having a hard time believing antidepressants are mostly placebo. If someone is truly suffering from mental depression and not just feeling down because bad things happened in their lives, then it just won't work. The whole point of depression is that it changes the way you think to the point of seeing everything as pointless and hopeless. what good is a placebo if you don't believe in it ?
And finally, treating depression by finding the root cause of it ? Once again, isn't depression all about not having a clear source ? if you can find what makes you sad then thats it, you're just sad.
In retrospect i see how the SSRI drugs where sold to me by the GP. I was simply told they would "up my happy hormones" I had to discover all the other side effects from taking them and doing extensive research only to find out most of the side effects( long and short term) could be just about anything so basically they're unknown.
if a side effect is feeling more suicidal then clearly these drugs aren't the best or safest option especially when PLAYING WITH THE BRAIN which scientist collectively don't know much about.
my awareness of the pharma companies has worked like a placebo for my anxiety cause i am content knowing I am not on those drugs. I would advise people to belive and seek the opinions and facts from the guinea pigs ... i mean people who have taken the drugs themselves.
My pshyc. team evaluates medications based on blood and urine and other samples taken prior to renewal of any meds, and work with me based on my physical and emotional responses to what I experience. They are pros, and I recommend consulting with SEVERAL pros prior to buying into a "foodguru" based claims that profit one entity.
SSRI legal prescription medication are not placebo. They are not that good. They work by shutting down a persons ability to feel any emotions good or bad. Many depresssed people suffer from not being able to feel enough emotion or empathy. We an SSRI emotions are basically turned off or dulled. For instance on an SSRI you you feel depressed but you also will not enjoy music. Its like the medical solution is turn people into pyschotic, unemotive, calm. Its a blanket approach to depression. Some people are depressed because they feel disconnected and less emotional than others. Some people have depression because the have too many emotions and are volatile. I think medication is needed that increases a feeling of welbeing, or connection to other. How about an oxytoxin RI , There obviously other things that can be done medication, other things other than seretonin. The solution is just to make people calm so they dont bother anybody but they dont function. Its a bad approach. Zoloft ? Its ok in some ways and I noticed some nice side effects, in other ways its worse there are bad side effects. That is what the doctor gives if you say you have depression ? Why is there not a drug that helps you feel more emotion ? That is one of the main issues, people feel depressed, They dont want to feel less, They want to feel more love for the world instead of nothing. Is there a drug like that ? .
I didn't begin taking antidepressants until I was in my early forties. From the time I was about 7 years old until beginning medication I suffered from headaches, upset stomach, sadness, fatigue, and weeping on a regular basis. After getting on the meds, those symptoms virtually disappeared. If this is a "placebo effect", then I'm all for it and recommend it highly !
As soon as I was told about the effects of taking psyche drugs I opted out of taking them. I figured I’d would rather suffer with mood swings then have toxicity and eventually liver and kidney disease or failure. I also determined to be proactive with my depression by swimming, walking and getting space rather than rely on a pill which would ultimately be more of a hindrance to my mental health than good. I surround my self with positive people and I have a spiritual belief that also gives me hope for the future instead of feeling like I have no future. So far I am doing ok and I’ve found an intergrative psyche dr who is treating me holistically with natural meds. I have been diagnosed with bipolar 2, Hasimotos and I am Perimenopausal with prementrual dysphoria. I’ve been hit with the F’ed up stick. May husband of 8 yrs was ready to walk and I am crying as I write this but I am determine to stay positive. I’ve got this!
So people that suffer for Depression according to this women shouldn't be put on andepressants , yeah ok then you would have more people killing themselves, andepressants help thats why there antidepressants.imagine if patients that are bipolar are off there meds how would they survive or act.I dated a girl with bipolar and when she wasn't on her meds it was terrible, and also she would mix booze with her meds which was a disaster as well
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.