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Pharmacology - ANTIDEPRESSANTS - SSRIs, SNRIs, TCAs, MAOIs, Lithium ( MADE EASY)

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💪⚡ Try Online Counseling: http://tryonlinetherapy.com/speedpharmacology If you are struggling with depression or any other mental illness consider online counseling with a licensed professional at BetterHelp. It’s far cheaper and more convenient than in-person counseling. Believe me, you are worth it. By using my referral link, you support this channel. Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered in this video include: monoamine hypothesis of depression, bipolar disorder, serotonin, norepinephrine, dopamine, receptors, mechanism of action of antidepressants; selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors ,tricyclic antidepressants, monoamine oxidase inhibitors, atypical antidepressants, and lithium. Antidepressants mentioned include: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Venlafaxine, Desvenlafaxine, Duloxetine, Levomilnacipran, Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Maprotiline, Nortriptyline, Protriptyline, Isocarboxazid, Phenelzine, Tranylcypromine, Selegiline, Bupropion, Mirtazapine, Trazodone, Nefazodone, Vilazodone, and Vortioxetine.
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Текстовые комментарии (234)
Richard Robertson (21 час назад)
I got depression trying to memorize antidepressants. Thank you speed Pharmacology you made me actually understand everything, and not try to brute force it like I was trying to do.
junior torres (5 дней назад)
Could you turn your generic videos into more USMLE type?
Syed Moris (5 дней назад)
MAO actually reduce BP mildly- I think this is the same reason why this is so - this also explains the bisphasic response of adrenaline. We have less of B2 receptors and more of Alpha 1 receptors - But the B2 receptors having a stronger affinity for Adrenaline and noradrenaline - so when there is a mild increase in adrenaline/noradrenaline the effect of B2 is dominant leading to vasodilation and reduction in BP At higher doses(say when we take tyramine) when we have enough adrenaline/noradrenaline to bind to both Alpha1 and Beta 2 the effect of alpha1 is dominant simply because we have more of alpha1 receptors in the blood vessel. I remember having read this on wikipedia though I cannot find it now so maybe I am extrapolating a bit. Hope someone finds this useful, someday.
Abel1120 conlget (8 дней назад)
so funny.. everyone has everything...im glad to be the only normal American ever. ... 🍻😂
karthikheyan .s (1 месяц назад)
Except this,ur all videos r too short plzz make sure
Damon T Aqua (1 месяц назад)
Don't take antidepressants you'll be permanently castrated
I Am Not A Robot (1 месяц назад)
Warning: Take some Xanax if you are willing to follow this nerdy narration until the end.
Madison Roberts (1 месяц назад)
You are so smart
vishal yadav (1 месяц назад)
Its really helpful Thankue so much
Pawel Sliwa (1 месяц назад)
Everything was clear then lithium popped up
Davids Mulvaney (1 месяц назад)
Anti depressants DON’T work. It’s merely a combination of good marketing techniques and the placebo effect. Nothing more. Furthermore, they often do MUCH more harm than good. Stay away from them at all costs.
Gilgamesh Of Sumer (5 дней назад)
+Davids Mulvaney i'm not implying anything. i'm asking you to prove your previous point.
Davids Mulvaney (5 дней назад)
Gilgamesh Of Sumer - then I have no idea what your implying.
Gilgamesh Of Sumer (5 дней назад)
+Davids Mulvaney i never made the claim so why should i prove myself?
Davids Mulvaney (5 дней назад)
Gilgamesh Of Sumer - sure. As soon as you can prove to me that these drugs are actually effective.
Gilgamesh Of Sumer (5 дней назад)
that's an incredibly dangerous thing to say. prove what you said was true.
mis ty (2 месяца назад)
Very helpful!! Clear and informative! Thanks!!!
Dale Allen (2 месяца назад)
Thank you for this demonstration. It is easy to understand and helpful.
mattspawn1975 (2 месяца назад)
Very well made video!
Aloysius Sebastian Prayogi (2 месяца назад)
thanks for the video, it helps so much.
Abdulwahab y.s (2 месяца назад)
thank you
Husam BAYAZİD (2 месяца назад)
fruitful video :)
Chandrani Dutta (2 месяца назад)
These videos are extremely helpful. Thank you :)
Esmatullah Amini (2 месяца назад)
tnx . its so helpful
Ben McCartney (3 месяца назад)
Cracking video bud, keep it up
Schizo &Human (3 месяца назад)
Thanks so much for this-very educational. I just started to take SSRIs and I wanted to know more about what it’s doing to my brain
danceballetacro (3 месяца назад)
I'm a graduate student in social work and am aspiring to be a mental health therapist
Ryan Taube (3 месяца назад)
Great explination. But good lord so many different drugs how you know whats good ???
mickey T (3 месяца назад)
as a long term depressed person this is a joke of hypothesis. only true cure is change of situation and support for the person to get a routine and problem solving skills back.
Dulmal Mj (4 месяца назад)
It was all going great until you reached Lithium haha but thanks for the great video :D
s_Toobii (4 месяца назад)
OmG!! Thank you so so much!! May Allah bless you!! Much much love, prayers, respect and gratitude for you..💓
muskaanrocks21 (4 месяца назад)
Thank you thank you thankyouuuuuuu
wing Ranile (4 месяца назад)
I\'m not sure but ,if anyone else is searching for dealing with anxiety try Nadazma Destroy Depression Helper (just google it ) ? Ive heard some extraordinary things about it and my buddy got cool success with it.
Krzysztof Filip Maksymilian Stypuła (4 месяца назад)
Thank you for this material, it puts everything in place :)
Yubraj Mahara (4 месяца назад)
very helpful...Thank you
Essko Raim (4 месяца назад)
man rly good tutorials. but u are making ''pharmacology'' videos-->so imo, it would be much-much better, if u would add also CI(contraindications) and DI (drug interactions), and also properly mention which drug is mostly/preferably used from such a group. simply complete pharmacology, may by time line of videos will be extended 2x, but it is definitely would by btter watch 30 mins videos than visiting boring PPT lections;)
itsmebxv (4 месяца назад)
Whoever watching don't ever take the medication unless you are so weak that you are bedridden...there is not much study in this area...they are simply using humans as rats to test their drugs.
Dokkasan (4 месяца назад)
His accent is so strong, that he is actually pronouncing similar sounding words that have different meanings. For instance, when he says serotonin, he actually says "certain."
Aiman Khan (5 месяцев назад)
Amazing video! V easy and complete
Eben Ether (5 месяцев назад)
Nice job!
somya pani (5 месяцев назад)
Thnks fr d concept ..
Anthony Xyy (5 месяцев назад)
Broken record research just diff talk do you not understand why they are little difference enough for different pattens but all basic drugs the same but lithium they are all made from same chemicals you are reading out of a book and trying to make it sound more complex like they do to sell more drugs
DiLLZGFX (5 месяцев назад)
KCL NS exam oh boy
Amy Potts (5 месяцев назад)
This video needs subtitles
Speed Pharmacology (5 месяцев назад)
Each of my videos contain subtitles. Look at the bottom of the YouTube video window as the video begins playing. You need to click on a small "CC" logo that will appear in this space, beside the "Change Quality" and screen-size icons.
glendalynne janacek (5 месяцев назад)
All these drugs r dangerous they are just as bad as Ritalin trust me do not let a doctor put you on this crap. Once you are on this drug is very difficult to get off again and the long-term side effects from taking these drugs not worth it. Pharmaceutical companies are just poison makers
Hiba Yaqub (5 месяцев назад)
Thank u so much....very helpful... Awesome...
outlaw tv (5 месяцев назад)
im depressed af constantly:( I just want to be at peace , if you know what I mean....
Nick John (1 месяц назад)
Try xanax or valium. You will feel in love again. But be warn. Highly addictive. It only takes me 2 mg of xanax for me to get hook. Unlike nicotine that need dozens of cigarrette.
Prekshi Sanwal (5 месяцев назад)
thnku really a great deal of help in clearing up my concepts
rowaida osama (5 месяцев назад)
شكرا لكم على هذه الفيديوهات القصيرة الأكثر من رائعه 💖❤ i love it
Oluwakemi Akinyode (5 месяцев назад)
Thank you!!!!!
Ggg (5 месяцев назад)
i thin anxiety patients dont use snris because its causes increase heat beat already anxiety patients has increase heaet beat
Ryno Jaffey (6 месяцев назад)
MAOIs now diet-safe. No decarboxylating enzymes in foods anymore to create tyramine, meaning no tyramine to lead to high blood pressure. Food and nutrition journals have been doing these analyses for 20 years now.
Sigmund Freud (6 месяцев назад)
This is a tremendous blessing..it's so easy
GFCmedia666 (6 месяцев назад)
nothing at all...
brian lupinsky (6 месяцев назад)
ssri's case canser ssri's case dibeates and heart attack some one need seu them trillons or dollars.
Ze _Jeff (6 месяцев назад)
It seems to me like depression, anxiety and all these disorders that are fixed by anti depressants are caused by our brains not being built for modern life. We still have the same systems that are in monkeys, pretty much.
balqissoo (6 месяцев назад)
I like your accent. It is easy to understand without using english subtitles(english is not my first language). Thank you so much teacher!
Think Paw Studios (6 месяцев назад)
yogita dixit (6 месяцев назад)
Can you please make a video on anti psychotic drugs...
Irene Austin (6 месяцев назад)
unfortunately there is only one "antidepressant" in all of this litany of drugs that treat dopamine deficiency and that drug is really dirty. Only one antidepressant ever actually to the market, Nomifensin, treated dopamine deficiency and it was withdrawn after some rare hematologic side effect. I suspect the real reason it was withdrawn was because it actually worked.
NauticalStrings (6 месяцев назад)
Antidepressants do NOT work, https://www.youtube.com/watch?v=UIm8fHxqUAM
enzyme20056 (7 месяцев назад)
It is a shame that selective reversible MAOIs like moclobemide (auroix) aren’t mentioned as an alternative to irreversible non selective MAOIs. Moclobemide is considered “weak”, but at the higher doses I got quite a boost from it, with very little side effects.
enzyme20056 (7 месяцев назад)
This video is quite excellent in summarising such a complex field of mood disorders and the different treatments. I predict that atypical antidepressants will become the dominant “class” of medicine marketed. There are just so many different molecules that seem to have some positive effect on mood. What class people respond to is still a lottery; even if geneotyping becomes involved in predicting the probability of success to one drug over another.
Eshwar Einstein (7 месяцев назад)
What a Fantastic video. Was able to explain tough concepts easily in an understandable fashion.Really look forward to more such videos. greatly explained. Thank you.
A Zee (7 месяцев назад)
This is amazing. Thank you
imene imaya (7 месяцев назад)
please video about antipsychotique
FARIHA RIZVI (7 месяцев назад)
A big thank you to make it very simple and understandable
Shirra Mims (7 месяцев назад)
i loveeeee youuuuu. thank you for the indepth pathway
danvil identity (7 месяцев назад)
I recommendation for Elumpa cure depression alchemist. It's perfect information and good job. You can find anti depression medications. Thank you.
sh alfoudri (8 месяцев назад)
awesome :) thank you so much
sh alfoudri (8 месяцев назад)
awesome!! :) thank you so much
sh alfoudri (8 месяцев назад)
awesome!! :) thank you so much
Heba Hefny (8 месяцев назад)
Amazing 😃✨thank you very much 😊
Behnaz P (8 месяцев назад)
thank you
Ranjith Jothi (8 месяцев назад)
Nice video sir
Ihtesham khan Babar (8 месяцев назад)
Kirandeep Sharma (8 месяцев назад)
Thank you so much for making it so easy. It is so helpful. If possible then please cover Serotonin Syndrome as well in your style.
David E (9 месяцев назад)
No offence but you sort of sound like the quack doctor from the Simpsons.
DEVADASU CHAPALA (9 месяцев назад)
Thank you for your wonderful explanation
Nyshia G (9 месяцев назад)
Your explanations and imagery to help understand and remember the concepts is pure intelligence! These videos are simply amazing and I thank you so much for sharing your knowledge and expressing the information in terms that are understandable!!
Dragana Mikic (9 месяцев назад)
here's a few things to try Work out why you are shy - the first step to solving a problem is to understand why it is there. Be comfortable about yourself - this makes it easier Challenge youself - you will feel better by taking action - especially by doing things that push your limits. (I discovered these and more tips on Martos magic method website )
05candyman (9 месяцев назад)
This guys voice is UNBELIEVABLY irritating ):
Don Draper (4 месяца назад)
05candyman That’s because of the abnormality in your alpha 1 receptors. You need one of the reuptake inhibitors. Watch the video again and pick your favorite.
Vitacure LLC (9 месяцев назад)
There are some side effects to SSRI's, and they are not for everyone. SSRI's may of course help if serotonin is low. According to "WRI," about 38% of depressives have lower than normal levels of serotonin, and that is why they tend to get depressed. In this case, SSRI's may help but still have side effects. In this case, other alternatives like nutritive support for underlying imbalances causing the problem can be at least as effective. Given to the wrong people, however, SSRI's can have fatal consequences (read the PDF "A Proposal for Prevention of School Shootings" - not directly related to this article of course but...): https://www.vitacure.me/blogs/news/difference-undermethylated-vs-overmethylated-symptoms
TraffeN (9 месяцев назад)
Can you smile cigarettes when eating ssri
Nick John (1 месяц назад)
You mean smoke? Yeah you can. But you will get headache. A big painful headache. Worst come to shove, vomitting or vertigo depending on the dose of Ssri and how many smoke you puffing. Source: myself.
HappyPapa (9 месяцев назад)
Fantastic Job!
stigfrurd (9 месяцев назад)
Sorry getting confuse about SERT, SSRI's and 5-ht receptors. are you saying "hypothetically" SSRI's are slow to show a response, because even though they block SERT that they also have an effect on dysfunctional 5-ht receptors that are " in a lipid raft" and the SSRI's ( along with inhibiting serotonin reuptake) that they accumulate around these g-protein rafts, helping to separate them and in turn allowing them to function better due to an increased ability to access cAMP ? In short: SSRI inhibit SERT & re-establish 5-HT functionality ( g-proteins in a lipid raft ) which takes a few weeks before effects are noticeable. ?
stigfrurd (9 месяцев назад)
And could you please do one on abrupt withdrawal of SSRI's and there physiological effect?
fastandeffective (10 месяцев назад)
Recent evidence revealed that antidepressant pills increase suicide risks by 2-5 times. [a][b][c][d][e][h] Cognitive behavioural therapy halves the risk of repeated suicide attempts. [k] Furthermore, antidepressants increased all cause mortality by 33%! [i][j] Another meta-analysis published in the British Journal of Psychiatry has found that even patients with the most severe depression can expect to get as much benefit from cognitive behavioural therapy (CBT) as those with less severe symptoms. [f] Even Behavioural Activation effectively decreases depressive symptoms. [g] Trained grandmothers are better than psychiatrists. References [a] http://journals.sagepub.com/doi/pdf/10.1177/0141076816666805 [b] http://www.bmj.com/content/348/bmj.g3510 [c] http://www.bmj.com/content/352/bmj.i65 [d] http://nordic.cochrane.org/sites/nordic.cochrane.org/files/public/uploads/theses/Emma%20Maund%20PhD%20thesis.pdf [e] http://www.bmj.com/content/355/bmj.i6103 [f] http://bjp.rcpsych.org/content/210/3/190.long [g] http://www.bmj.com/content/356/bmj.j914 [h] http://www.bmj.com/content/358/bmj.j3697/rr-4 [i] https://brighterworld.mcmaster.ca/articles/antidepressants-associated-with-significantly-elevated-risk-of-death-researchers-find/ [j] https://www.ncbi.nlm.nih.gov/pubmed/28903117 [k] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650127/
noha mohamed (10 месяцев назад)
If the TCA block alpha receptors so how so do they perform their function which depends on increasing NE
Medico world (10 месяцев назад)
Can u explain mechanism of action of tianeptine and amineptine?
Medico world (10 месяцев назад)
How do tricyclic antidepressants and mirtazapine cause weight gain and increased appetite?
Bodoor Hakami (7 месяцев назад)
Mirtazapine makes me eat alot..I gained 5 kilos in 2 weeks
TDupuis (10 месяцев назад)
Thanks for explaining these beyond how they function, and explaining the pros and cons with the visual example.
niharika anantoji (10 месяцев назад)
Please make a video on antipsychotic drugs too
V5 Jhan (10 месяцев назад)
\(^_^)/ Hoorayyyy
factsneverlie (11 месяцев назад)
Anti depression pills should be used to make a balance to ur mind . U also have to make positive life changes ,change diet , exercise , positive thinking , and so on. If depression last more then a month it probably is a chemical imbalance.
Paul Owen (11 месяцев назад)
Tomorrow my medication will change from citalopram to effexor. This video has been extremely helpful and has also made a very confusing Illness somewhat easier to understand. Thank you
Yuna Vazquez (11 месяцев назад)
Thank you very much your videos are really helpful and the presentation is great!!! Could you please make videos about antipsychotics, anti mania,  sedative hypnotics, antiepilectics and anti-parkinson drugs?
Baaz Tech (11 месяцев назад)
just one question plz answer me i am your huge fan sir..... do you follow lippincott pharmacology??? because your lectures more that 90% data is related to that book.....
Parnate (11 месяцев назад)
12:50 -- FALSE. If you had only read even ONE journal article on MAOIs and food interactions in THE LAST 30 YEARS, you would know that there is hardly any risk of MAOI - food interactions anymore. Interestingly, MAOIs increase serotonin levels several times more than do (S)SRI anti-depressants. This ought to be of great import to those pitiable chronic depressives whom the new-age (SSRI) anti-depressants don't serve.
Parnate (11 месяцев назад)
Peter Hell Hello Peter: 30 mg of Parnate is unlikely to constitute a therapeutic dose in most people, the end result of which is that the imbecilic doctors (and NHS) will say, well, Parnate doesn't work for you. To test for the minimum dose that will have a therapeutic effect on a patient, blood pressure should be taken, then after you stand, take it again. A blood pressure drop of 15 points systolic on standing indicates that initially sufficient MAO is being inhibited. Doctor and patient can then track depression symptoms and increase if necessary, up to 90 - 120mg per day. I say 120mg as some psychiatrists have found that even after all MAO has been inhibited by Parnate, that there is additional benefit up to 120mg - this is anectdotal but a possibility.
Parnate (11 месяцев назад)
Peter Hell I would second what D Snyder said. The literature and expert opinion supports that doses over 60mg can give increasing therapeutic benefits. A systolic BP drop of 15+ points standing (orthostatic) indicates that a therapeutic dose has been reached, but doesn't indicate a max.
David Snyder (11 месяцев назад)
DISCLAIMER: your treatment is up to your psychiatrist and I am not diagnosing you or giving medical advice as I am not familiar with your case or treatment history. Anything I write is informational only and not meant to be taken as medical advice. The American Psychiatric Association 2010 guidelines endorse going up to 60 mg/day in divided doses if needed (other tertiary sources back this up as well). If your psychiatrist goes by the British Association of Psychopharmacology then there is no dosing statement in those guidelines. Using a 60mg dose comes with the risk of increased side effects (activation, insomnia) but it is a well-studied dose.
David Snyder (11 месяцев назад)
I am a psychopharmacologist and I want to thank you for pointing this out. The fears of prescribing MAOIs (dietary concerns and pharmacodynamic interactions) are vastly overblown and limit exposure for many people who could benefit from this class. I've even recommended starting low-dose nortriptyline and phenelzine at the same time (TCA + phenelzine combo has been studied for decades; https://www.ncbi.nlm.nih.gov/pubmed/6376486 ) in a patient with ECT non-responsiveness and had a good result with no safety concerns.
Jackson Spitts (1 год назад)
I take Paroxetine because it helps me to kinda cope with my clinical depression
usulgekte2 (1 год назад)
thank you so much for posting! My teacher keeps saying i don't have to know how these medicines work but i do need to know the side effects. Because of this video i can finally relate the drug to the side effects.
Infinity 58 (1 год назад)
i was prescribed effexor for minor anxiety by my doctor i looked this drug up and people saw it has withdrawl symptoms worse than heroin some people say withdrawl will cause horrible migrains brain zaps feelings of no emotions at all (zombie like) and many more terrifying symptoms. I think something as serious as this shouldnt be prescribed for minor anxiety what the hell these are dangerous drugs why are they prescribed for any social or mental problems however minor??
Nick John (1 месяц назад)
Ssri withdrawal is easy peasy and mild than other withdrawal. Benzos and opiod is literal hell if you try cold turkey method. You could die from these two, but not SSRI
Sukhjeevan Mahil (1 месяц назад)
+Lexi B weed was what gave me anxiety in the first place
Gregory McDonald (2 месяца назад)
Effexor withdrawal does have brain zaps.
Lexi B (4 месяца назад)
Try weed or cbd oil! Little to no side effects if it doesn't work out.
H. M. Mull (9 месяцев назад)
Infinity 58 - LOTS! Millions maybe. I'm not sure about the stats. I hope you're worrying less! Remember you're feet are always on the ground, even if you're not.
DSK (1 год назад)
just great work. thanx
Onwe Chinwe (1 год назад)
Thank you sir !!!
sm tanvir (1 год назад)
fantastic video,,,,,plz keep going on
Sivi Sivi (1 год назад)
fallen in luv with pharm becoz of u.......my hearty thanks to u..... ☁🎈🎈☁🎈🎈☁ 🎈🎈🎈🎈🎈🎈🎈 🎈🎈🎈🎈🎈🎈🎈 ☁🎈🎈🎈🎈🎈☁ ☁☁🎈🎈🎈☁☁ ☁☁☁🎈☁☁☁
sam dot (1 год назад)
https://youtu.be/--tK7SK3PxE antianxiety drugs

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