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Making Sense of Antidepressants & Health | The History, Logic and Current Science

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Get 10% off a Dashlane premium subscription at https://www.dashlane.com/WIL with offer code whativelearned ▲Patreon: https://www.patreon.com/WILearned ▲Twitter: https://twitter.com/jeverettlearned Four things to consider when you're trying to make sense of never-ending contradicting pieces of health information: 1. The History 2. The Context 3. The Mechanism 4. The Short Term vs. Long Term Using these points, the video gives some quick examples of how this can be applied to different nutrition information, but the reoccurring example for medications is antidepressants. Check out on twitter: Rich Roll [ @richroll ] ‏ & Mikhaila Peterson [ @MikhailaAleksis ] -You can find Mikhaila's story at http://mikhailapeterson.com/about-me/ & There's a very interesting interview with her here: https://www.youtube.com/watch?v=zJlCjayk1HQ&t=8s -And, Yes, Mikhaila is Jordan Peterson's daughter. Jordan Peterson also had terrific health improvements from doing an elimination diet similar to Mikhaila's and then more improvements from switching to a full "carnivore" diet: https://www.youtube.com/watch?v=HLF29w6YqXs Robert Whitaker's book "Anatomy of an Epidemic" is the source for some of the information in here and is a very interesting read: https://amzn.to/2L64hSY TRANSCRIPT & LINKS: https://www.patreon.com/posts/20191380 For Business inquiries: joseph.everett.wil@gmail.com
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Текстовые комментарии (895)
What I've Learned (4 месяца назад)
Just a heads up: The original title of the video was "How to Make Sense of So Much Health Information" Which I suppose is more accurate of the goal of the video - the aim is to provide some thinking tools to navigate all the different information on health and medications popping up nowadays. However, about 65% of the video focuses on antidepressants, so the new (current) title is more accurate in that sense.
JosephKing75 CBP (1 месяц назад)
It depends who you ask tbh, if you ask Lil Pump....: "Pumping on X pumping on X pumping on X pills(X=Xanax)", all jokes aside, I recomend cbd tbh, but, as with everything, you need to learn to make a complete consumtion list for your day to day needs, as in, having everything planned out and so on.
bearjew (2 месяца назад)
Interesting content
0000song0000 (2 месяца назад)
What I've Learned have you learned información about anxiety meds? thanks
M.L. CH (3 месяца назад)
alan pompom (16 минут назад)
Well that explains that I need to keep getting my medication to be always increasing or else relapse on the medication. I might need to ask my psychiatrist about this when I meet them.
Name (4 часа назад)
Making -sense- *fun* of
chcken is fod (1 день назад)
They don't
pozsoz (1 день назад)
i've used all kinds of drugs, legal and illegal, and the worst for me were ssri's prescribed by a psychiatrist, wouldn't recommend them to anyone
Frank Bowman (1 день назад)
"How do antidepressants work?" In my personal experience, not worth a damn. :(
octaneblue6 (2 дня назад)
So -- confronting some of the antiquated research you cited about 5-HIAA levels in the cerebrospinal fluid. Simply put, serotonin is everywhere. Like—everywhere. It's been proven unreliable to tap into someone's spine and expect that indirect relationship to tell you anything about active serotonin levels in their brain. Coupled with the fact that, you know, some people metabolize serotonin faster than others and may actually have less active serotonin but more 5-HIAA, and you see why this data is worthless.
Dustin Kleiboer (2 дня назад)
Did you say David Banting was one of the inventors of insulin? His name was Frederick Banting! Not David!
AnduRo (3 дня назад)
2:46 as far a i know Insulin was made by a Romanian called: Nicolae Paulescu
Colin Shea (4 дня назад)
Sir FREDERICK Banting my dude.
Ky Tran (5 дней назад)
I know several people who swear on magic mushrooms (in micro doses and larger therapeutic) being the best treatment for depression and new studies seems to support this as well. It would be interesting to see a video about the science behind this.
Huzeyfe ilgen Bilgen (6 дней назад)
I just began taking antidepressants and stopped as I listen:)
Tyler Scurlock (6 дней назад)
Dude I freaking love your channel. It's so hard to find reliable dietary and medical advice.
david dawson (8 дней назад)
Thank you
William David (9 дней назад)
I know that at the end of the video you said it's more important to ignore all the information that isn't relevant but I still find myself trying to wrap my head around if I should still be taking antidepressants. I've been doing other things to help my depression such as socializing, eating better, exercising regularly, cutting out refined foods and drinks,etc. But I'm still wanting to know if I should be taking medication, as you explained in the video.."Antidepressants were helpful in the short- term but not for long-term". Mental health(along with nutrition) just leaves me with so many questions..
latestorder (12 дней назад)
5:30 DAT PANCAKE THO.......
rivdan 238 (13 дней назад)
Lisa I want to buy your rock LOL
these nuz (13 дней назад)
The best antidepressant is listening to your heart and inner voice.
Marc Padilla (15 дней назад)
Serotonin reuptake receptors.
MotherNature (15 дней назад)
I am 100% sure that without the medication I would have ended my life. It kept the anxiety down, and turned me into a mental zombie. However, it kept me alive until they slowly slowly reintroduced me to emotions and a normal everyday life. Despite this it is also antidepressants that killed one of my friends by giving them enough "energy" and initiative to actually end their life. Maybe it is unfair to blame medicine and maybe it was inevitable. I think it is a true double edged sword. As much as it can wreck one person it may also work wonders for someone else. Still the logic behind why antidepressants work is far beyond my intelligence. It is such an interesting subject I wish I could learn more.
Asi H (16 дней назад)
Y'all should read Peter breggin books
hipnhappenin (16 дней назад)
Isn’t it pronounced “eye-let”?
TPQ1980 (18 дней назад)
I had depression for 15 years *before* taking SSRIs. I tried *everything* including diet changes, exercise & talk therapy but I just kept getting worse. I now take an SNRI. Antidepressants have helped more than anything else I've tried.
Sam Handwich (18 дней назад)
2:23 Islets is pronounced "eye-lets", not "is-let" :)
alan2102 (18 дней назад)
between 9-11: you excluded a whole lot of information that supports the monoamine hypothesis of mood disorders. Also, there are multiple mechanisms, some involving neurosteroids, not just monoamines.
CoolDudeClem (19 дней назад)
If you live in UK and it's winter, you have a reason to be depressed.
Fag Kapilar (21 день назад)
SSRIs - Antidepressants that work well in severe cases but are pretty much as effective as placebo for other people.
Carson k (23 дня назад)
Anti Depressants have never helped me.
Sigurður Ólafsson (23 дня назад)
A scathing discussion of anti-depressants. Currently, 14% of the Icelandic population is on SSRIs. Last year my brother, who had suffered from depression and anxiety for some time, was prescribed a new SSRI, Sertral, after a few minute consultation with a psychiatrist following a breakdown and suicidal thoughts. There was no plan for follow up. A few weeks later, he committed suicide. Why isn't there more discussion regarding these drugs. They keep getting more and more common in spite of limited effectiveness and serious side effects. WT actual F?
Sigurður Ólafsson (1 день назад)
+Asi H Thank you. He was on some other anti-depressant, but I'm not sure which one. Anyway, prescribing SSRIs without any plan for follow up is very irresponsible and indicative of a broken mental health system.
Asi H (16 дней назад)
Really sorry for your loss man, was he on other drugs before the latter? ):
MeriCloud (25 дней назад)
I like yours videos c: Just I think it would be better to not refer to depression as a "all or none" condition. Antidepressants are not recommended for low or mild depression, but have proven effective for severe cases. Maybe the reason they cause more problems than none is because they are over prescribed to people that can cure their depression by making life style changes. Others, may need the drug to start making any change or even consider the possibility of a future.
Oregonism (25 дней назад)
That's Jordan Peterson's daughter!
Chris Reyes (26 дней назад)
please tell me how to stop taking prozac and wellbutrin! ive been taking antidepressants since 2004.
Asi H (16 дней назад)
Do no stop abruptly! Do a slow taper like it suggested in surviving antidepressants. Com
Vincent Batchelor (26 дней назад)
give antidepressant discontinuation syndrome a look up. if you can assuage symptoms like that hopefully you can move towards quitting those pills soon. hoping you feel better soon ❤️
Chris Reyes (26 дней назад)
Ii bet that carnivore chick has constant diarrhea
Miriam Calypso (27 дней назад)
Wonder what my psychiatrist would say if I questioned his integrity on the basis of a YouTube video that cherry picked only studies which strengthened their point... I'm so sick and tired of pseudo science and I also wanna mention that changing your diet in such extreme ways portrayed at the beginning of the video could also be placebo, shifting your focus on another part of your life
Vincent Batchelor (25 дней назад)
+Miriam Calypso i completely agree with you in that we should trust our health professionals. that being said, while his message may come off as "be skeptical of your health professionals", i think the goal was to "provide some thinking tools to navigate all the different information on health and medications popping up nowadays" as he puts it.
Miriam Calypso (26 дней назад)
+Vincent Batchelor I have to admit that I wrote this comment rather impulsively out of a feeling of frustration, the claims in the video probably have their legacy and the research done isn't that much of pseudo science so I apologize for the generalization... however I still think that the message - not to trust your doctors who genuinely studied to get their degree - can to some extent be harmful
Vincent Batchelor (26 дней назад)
while it is fair to say that some of the arguments on the video are reductionist and one-sided, i tend to resonate with his view more than the view of the industry selling antidepressants. that being said, a youtube video isnt the best format for a well-supported and lengthy debate in a concise manner.
yaggle fraggle (1 месяц назад)
Serotonin is inhibitory, so maybe it decreases depression by blunt your emotional response to stressors.
Akram Safirul (1 месяц назад)
This video made me depressed
Vincent Batchelor (26 дней назад)
but will you go get some antidepressants?
Depression to Expression (1 месяц назад)
8:01 me and Mikhaila, cool! Even though I take antidepressants, I really appreciate you doing this video.
Vincent Batchelor (26 дней назад)
out of curiosity, have you experienced any of the complications he mentions?
10jconway (1 месяц назад)
what film was that shown at the start?
Vincent Batchelor (26 дней назад)
swiss army man lol
C (1 месяц назад)
What I have learned, Kids if you want to use Molly just make sure to take an antidepressant before you go out to party and all things will be ok.
A T (1 месяц назад)
I think Ive become obsessed with your content 🤦🏻‍♀️
SciSci Toys (1 месяц назад)
Not true that SSRI's are placebo, it is VERY VERY easy to test this, take Paxil 20mg for 6 months, then stop them cold Turkey, you'll see what happens to your brain chemistry, you will feel terrible, more than terrible. No in the past the people with depression would kill themselves, anti depressants can be a Godsend and save people from suicide.
Vincent Batchelor (26 дней назад)
i think thats just called antidepressant discontinuation syndrome. placebo and withdrawal are different things. also, not all depressed individuals are suicidal, and antidepressants can lead to suicidal tendencies too. would you want to take a medication that might cure you, make you want to kill yourself or do nothing much?
Terence Washington (1 месяц назад)
Well done!
Damo Revo (1 месяц назад)
Our brains got bigger and our guts smaller when man learned to harness fire. Cooked food made it unnecessary for our gut to be so big as less time was required for digestion and extract nutrients.
VanCamelCat (1 месяц назад)
I was honestly surprised the sponsor was not Brilliant, given how much incredible you are at critical thinking. So impressive!
Lawrence H (1 месяц назад)
A doctor got really angry at me when I tried to ask what the drug she was giving me actually does. I wouldn't give up, since personally I dislike taking any drugs or medicine at all. After belittling me, insulting me, and making my situation severely worse, she finally said, "I don't know", and added one final jab at me. I didn't take that drug. I had no idea what it was, I had no idea what it did, and neither did apparently she. I don't know would've been a great answer, we could've looked it up and learned something.
Number Number (1 месяц назад)
We know because the drowning mice squirmed a little bit faster.
Vincent Batchelor (26 дней назад)
induced stress 😥
Mr Jenkins (1 месяц назад)
Frederick Banting...
Nick Johnson (1 месяц назад)
These things are toxic. They stole my childhood and destroyed my health. Stopping them was the best thing I ever did.
Alpha Dog (1 месяц назад)
Please can you make a video on probiotics, you really got my attention in your gut/brain video. The fact that weight and personality can be transfered completely freaks me out and can also explain why certain people never lose weight no matter what!! It is an incredible subject and needs more attention.
Michael Winter (1 месяц назад)
This video leaves out the last 10 years of research. Serotonin is a cause of inflammation. Inflammation is an inducer of depression. Changes to serotonin levels changes inflammation in the gut and immune response. I’m not smart, so you should look it up yourself.
Vincent Batchelor (26 дней назад)
a bit reductionist, but in essence on the right track. i tend to stick more with: why should i trust research funded by the person selling me drugs telling me that their drugs are safe. that would be like a drug dealer showing you a paper saying opioids are safe. oh wait...
Kieren Moore (1 месяц назад)
Is that quote at 5:09 correct ?!! ... Shouldn't it read something like, "headaches are caused by too much blood" ... not "too much blood loss" ... otherwise, I fail to see how any of that makes sense, even as an example of specious reasoning!! ?! Seems like a misquote/one too many instances of "loss" there, if you see what I mean ... ?! Cheers!
Tonraq Korr (1 месяц назад)
More money in curing symptoms, than cure m i right?
Vincent Batchelor (26 дней назад)
even more money in making sure everyone is continually buying your pills
awesomethomas97 (1 месяц назад)
Could you cover ADD an ADHD?
felicia cooke (1 месяц назад)
I just stopped taking my anti-depressants one day. I tell people that I consulted a doctor first but I didn't. I just stopped. I weighed the pros of its benefits against the cons of its side effects and made a choice. Not everyone is in a mental or environmental space to do that successfully and without harming themselves in the long run. The one thing I can say, and what I think a lot of people can agree on, is that combo foods that combine fat, sugar, and carbs: cakes, pastries, creams, syrups, breads, candies, etc. really do the body and the brain the most harm. If everyone were to just cut those kinds of combo foods out of their diet, the insulin spikes and other hormonal imbalances that these foods cause would stop contributing to the severity and longevity of depression. You can't change traumatic experiences or genetic predisposition but you can change diet.
Ruben Montes (1 месяц назад)
Very well made video!
bellboy (1 месяц назад)
My doctor started me Mirtazapine, a low dose. I moved back to England to care for my mother, leaving my 16 & 12 y/o children, behind. I was reluctant to take a pill as I thought I had every right to be sad and depressed and no pill would help that. I tried it for 2-3 months, initially my sleep was improved, a secondary reason she rx'd it. I felt draggy during the day, though and not as clear headed, so I stopped taking it. I know take numerous vitamins/supplements and sleep better and "feel" healthier, not really sure on that one.
spicyonion (1 месяц назад)
Than more i watch your videos,more i want to just read the entire book school give us each year and don't use it entirely after all
Steven Vega (2 месяца назад)
How about panic attack syndrome?
Twadeps (2 месяца назад)
Do a video on psilocybin as a medicine for depression please! Love the scientific content
NEKRO Channel (2 месяца назад)
Correct fact: Insulin was discovered by romanian *George Pãulescu*
Patrick Dukemajian (2 месяца назад)
Awesome video but I hit "dislike" because you said "historical" when you meant "historic".
[Vitz!] (2 месяца назад)
You used the LONG LONG MAAAAAAAAAAAAN commercial in this video. 10/10
Arianna Spencer (2 месяца назад)
So when you say exercise is just as effective as Zoloft in aiding depression, does this mean exercise does not benefit depression at all?
Roger Syversen (2 месяца назад)
ha, jeans
OfficialEDirty (2 месяца назад)
I have tried several times to get off my antidepressants and always end up being depressed again.
Nick John (4 дня назад)
Dont listen to this video. Many unchecked facts and probably even some psychiatary would disagree
M D Adams (2 месяца назад)
thank you for a well researched logical channel
Jeff Herrera (2 месяца назад)
Thanks for the great content!
badseed86 (2 месяца назад)
This is misinforming. Medication is indicated only for major depressive episodes not all depressions. Furthermore one depressive episodes is not an indication for life long medication, the guideline after one single depressive episode is medication for 6-12 months. Even after one or two relapses you wouldn't have an indication for life long medication. By comparing depression with medicine to depression without, you are not explaining the obvious, that severe depressive episodes are way more likely to have a worse prognosis and way more likely to get medication. What is more, the chemical imbalance theory was an idea of the 70s and 80s. Today the main focus is brain metabolism, networking of the brain, and inflammation. This video like most of this channel relies on anecdotal facts, misleading and potentially harmful information.
jo jo (2 месяца назад)
Why does your thumbnail look like Lemongrab and why does it fit so well?
Maxx G (2 месяца назад)
Furry In Finley (2 месяца назад)
dont know about you but going onto medication ended my depresion cycle. didnt matter if i ate well and lost weight or did the oposite, am glad i can experiance life without such deep lows .
Natasha Navotnaya (2 месяца назад)
Before committing suicide , try antidepressants. Just sayin’
Melmano (24 дня назад)
Natasha Navotnaya I hate antidepressant and the fact that it turns people into zombies. Even worse when these people don’t even realize how their personality has changed. But still I agree. I guess taking the risk of becoming a zombie is worth not dying..
SpiderS (2 месяца назад)
Antidepressants and antipsychotics medications have been real life savers for me.
Oscar Fitzpatrick (2 месяца назад)
I study psychology and have taken anti-depressants in the past before quitting them and continuing with some CBT, today I feel no depression or anxiety, so here's what I've learned about anti-depressants: Antidepressants are exogenous chemicals that affect production and uptake of neurotransmitters in various different ways across multiple brain structures. In other words, when you take an antidepressant that decreases serotonin, you are not simply "decreasing the sad chemical", you are affecting how serotonin is used across thousands and thousands of neurons in multiple different brain pathways. Serotonin is a common neurotransmitter that your brain uses for lots of different tasks, not just mood regulation. Think of neurotransmitters like building blocks of your brain's communication, rather than chemicals that have specified functions. What you eat also effects your neurotransmitters too.
videoschmo (2 месяца назад)
4:26 So why did researchers suddenly switch to Serotonin if the evidence up to that point suggested Norepinephrine?!
Jean Marabou (8 дней назад)
Well if you want more info, you can go to read Ray Peat's articles on serotonin and SSRI to dig a bit.
Erin (8 дней назад)
+alan2102 I took many different ssris and they did nothing, it was only when I tried an snri that it actually made some sort if difference
Jean Marabou (14 дней назад)
+alan2102 "you're on the right track" tell us more plz, i'd love to see some links and stuff to get deeper into the rabbit hole. :)
alan2102 (18 дней назад)
GREAT great question! And that is one of the problems with the APPLICATION of the monoamine thesis (not the thesis itself!). The way it has been APPLIED focuses much too much on serotonin. This is partly because the drug companies came up with a slew of serotonin-related drugs, and of course wanted to profit from them. It is a whole complex story, but you're on the right track. The serotonin-ONLY treatment approach is off the beam for a great number of sufferers.
Michael The Sociopath (2 месяца назад)
Maybe Jordan Peterson’s daughter has a messed up microbiome. Her gut bacteria may be rejecting foods like bananas, rather than her body itself.
Supernatural Intelligence (2 месяца назад)
How to edit videos like this????
ekstrajohn (3 месяца назад)
TLDR: we don't get how SSRIs work, but we still use them because there is evidence they do something that helps people. It is OK to use them to treat your depressed episode only the first time (ie for 1 or 2 months on the meds), but if your doctor recommends you go back to them if you have another episode, be very critical and make sure it is absolutely necessary before you do.
Phi1eap (3 месяца назад)
Excercise, socialize, lower inflammation and stress, sunbath, supplement DHA, zinc, vitamin D3. Better than drugs.
B o r i s s l a v (3 месяца назад)
That's not how carbs, dietary fats and metabolism work..
just that guy (3 месяца назад)
What a goldmine of a channel
holnrew (3 месяца назад)
Interesting subject. Sadly I'm one of those on antidepressants for life, it's pretty annoying but better than how I feel without them. I definitely think that for some people they're prescribed too readily, but it's a cheaper and easier option than proper therapy. I hope something better comes along in my lifetime because I still feel broken on the tablets, they just stop me from wanting to die so much. Diet is an interesting factor,and I believe other features of modern life contribute to the cause.
raz gaz (3 месяца назад)
second time mentioning Peterson's daughter in a video. Crush maybe?
gabriel aponte (3 месяца назад)
the other thing is that psychedelics work for similar cases and they focus on serotonin and neurogenesis
gabriel aponte (3 месяца назад)
the thing is maoi lower 5-hiaa levels because of breakdown so its def not perfect similarly breakdown metabolites of dopamine hva and adh are not indicators of dopamine levels because come and Mao break them down and can in fact be a sign of low dopamine, norepinephrine because of fast break down especially with someone with high activity Mao or come enzymes , in fact its this gene comt that is often used to be tested to see if the patient may benefit with stimulants and it is comt along with mthfr (folate gene that helps synthesize sam-e, dopamine , norepinephrine, serotonin) that predict depression symptoms , as well as negative symptoms in schizophrenia (which mimic those of depression)
gabriel aponte (3 месяца назад)
I have so much respect for those early scientists/doctoers who discovered some of these things with so little
Inky (3 месяца назад)
I exercise, eat healthy, sleep well and I'm still depressed anyway :(
M.L. CH (3 месяца назад)
M NI (3 месяца назад)
What about the use of anti ds for menopausal symptoms such as hot flushes?
Matinator (3 месяца назад)
Please realize that the ending studies are about a depressive episode - after many many years of recurring depressive phases, trust me when I say: It does not just go away.
smp156 (3 месяца назад)
i've been on just about all the SSRIs that the pharmaceutical industrial complex has to offer. i couldn't tell what did what, if anything at all, except give me horrific... absolutely life-destroying side effects and withdrawl symptoms.
figaro fig (3 месяца назад)
So off topic!
Frost Night (3 месяца назад)
I wish I had never been put in antidepressants. I was put on them in my sophomore year of high school by my general physician (Paxil, while on Accutane, which was not okay to combine). I now take 40mg Prozac every day and I struggle with depression chronically. I want to be a happy person. Even when I was having a very happy time in my life last winter, I wanted to be taken off my medicine. I was tapered off, but became so immensely suicidal and depressed I had to resume. This happened every time I tried to quit my meds in the past. And now I'm on 60mg of Vyvanse to keep me awake every day, since I now have Narcolepsy.
Asi H (16 дней назад)
Surviving antidepressants has a great tapering and reducing guide, you should try it
shikamaru nara (3 месяца назад)
Antonio Ballve (3 месяца назад)
Anti-depressants have saved people's lives. but you know, meh, that is out of the scope of this video. Well that detail you are leaving out of the video is the only thing that actually matters in this whole topic. They don't work for some people, but they DO work for countless of people and have been life saving in countless situations. Are anti depressant perfect? No, but they seem to be the best we have right now
Jake Karpinski (5 дней назад)
EmmanuelMess For what? Most of those points were my own. For the rest, have you heard of Google?
Jake Karpinski (5 дней назад)
Melmano Yes. Because the people who are the most disturbed are the most likely to both A- need and get antidepressants B- perform acts of violence Prior dual causality is the perfect example of non casual coincidence.
EmmanuelMess (5 дней назад)
+Jake Karpinski Do you have a source for that?
FlezzDurjis (21 день назад)
depression and suicide rates are increasing, so i would argue SSRIs are not enough. And there are better options on the horizon, the FDA recently granted psilocybin and MDMA breakthrough therapy status for depression because they perform so much better than SSRIs and therapy.
Melmano (24 дня назад)
More or less every american school-shooting is related to anti-depressants....coincidence?
Simon Bormans (3 месяца назад)
I just started taking venlafaxine to treat my depression. I'm still on the lower starter dosage and after watching this video i am seriously doubting continuing to take it
migkillerphantom (3 месяца назад)
Wait, is that predator chick Jordan Peterson's daughter?
K5TRL (3 месяца назад)
Thanks for the info!
Shiggindorf Swaggalou (3 месяца назад)
I listened to this half asleep so I kept thinking about the corrrelation between depression and Nora Ephron
Stravo Lukos (3 месяца назад)
And then there are those who can't remember a time when they weren't depressed, even as children.

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