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Four things to consider when you're trying to make sense of never-ending contradicting pieces of health information:
1. The History
2. The Context
3. The Mechanism
4. The Short Term vs. Long Term
Using these points, the video gives some quick examples of how this can be applied to different nutrition information, but the reoccurring example for medications is antidepressants.
Check out on twitter: Rich Roll [ @richroll ] & Mikhaila Peterson [ @MikhailaAleksis ]
-You can find Mikhaila's story at http://mikhailapeterson.com/about-me/ & There's a very interesting interview with her here: https://www.youtube.com/watch?v=zJlCjayk1HQ&t=8s
-And, Yes, Mikhaila is Jordan Peterson's daughter. Jordan Peterson also had terrific health improvements from doing an elimination diet similar to Mikhaila's and then more improvements from switching to a full "carnivore" diet: https://www.youtube.com/watch?v=HLF29w6YqXs
Robert Whitaker's book "Anatomy of an Epidemic" is the source for some of the information in here and is a very interesting read: https://amzn.to/2L64hSY
TRANSCRIPT & LINKS: https://www.patreon.com/posts/20191380
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Just a heads up: The original title of the video was "How to Make Sense of So Much Health Information"
Which I suppose is more accurate of the goal of the video - the aim is to provide some thinking tools to navigate all the different information on health and medications popping up nowadays.
However, about 65% of the video focuses on antidepressants, so the new (current) title is more accurate in that sense.
It depends who you ask tbh, if you ask Lil Pump....: "Pumping on X pumping on X pumping on X pills(X=Xanax)", all jokes aside, I recomend cbd tbh, but, as with everything, you need to learn to make a complete consumtion list for your day to day needs, as in, having everything planned out and so on.
So -- confronting some of the antiquated research you cited about 5-HIAA levels in the cerebrospinal fluid. Simply put, serotonin is everywhere. Like—everywhere. It's been proven unreliable to tap into someone's spine and expect that indirect relationship to tell you anything about active serotonin levels in their brain. Coupled with the fact that, you know, some people metabolize serotonin faster than others and may actually have less active serotonin but more 5-HIAA, and you see why this data is worthless.
I know several people who swear on magic mushrooms (in micro doses and larger therapeutic) being the best treatment for depression and new studies seems to support this as well.
It would be interesting to see a video about the science behind this.
I know that at the end of the video you said it's more important to ignore all the information that isn't relevant but I still find myself trying to wrap my head around if I should still be taking antidepressants. I've been doing other things to help my depression such as socializing, eating better, exercising regularly, cutting out refined foods and drinks,etc. But I'm still wanting to know if I should be taking medication, as you explained in the video.."Antidepressants were helpful in the short- term but not for long-term". Mental health(along with nutrition) just leaves me with so many questions..
I am 100% sure that without the medication I would have ended my life. It kept the anxiety down, and turned me into a mental zombie. However, it kept me alive until they slowly slowly reintroduced me to emotions and a normal everyday life.
Despite this it is also antidepressants that killed one of my friends by giving them enough "energy" and initiative to actually end their life. Maybe it is unfair to blame medicine and maybe it was inevitable.
I think it is a true double edged sword. As much as it can wreck one person it may also work wonders for someone else.
Still the logic behind why antidepressants work is far beyond my intelligence. It is such an interesting subject I wish I could learn more.
I had depression for 15 years *before* taking SSRIs. I tried *everything* including diet changes, exercise & talk therapy but I just kept getting worse. I now take an SNRI. Antidepressants have helped more than anything else I've tried.
A scathing discussion of anti-depressants. Currently, 14% of the Icelandic population is on SSRIs. Last year my brother, who had suffered from depression and anxiety for some time, was prescribed a new SSRI, Sertral, after a few minute consultation with a psychiatrist following a breakdown and suicidal thoughts. There was no plan for follow up. A few weeks later, he committed suicide. Why isn't there more discussion regarding these drugs. They keep getting more and more common in spite of limited effectiveness and serious side effects. WT actual F?
+Asi H Thank you. He was on some other anti-depressant, but I'm not sure which one. Anyway, prescribing SSRIs without any plan for follow up is very irresponsible and indicative of a broken mental health system.
I like yours videos c: Just I think it would be better to not refer to depression as a "all or none" condition. Antidepressants are not recommended for low or mild depression, but have proven effective for severe cases. Maybe the reason they cause more problems than none is because they are over prescribed to people that can cure their depression by making life style changes. Others, may need the drug to start making any change or even consider the possibility of a future.
Wonder what my psychiatrist would say if I questioned his integrity on the basis of a YouTube video that cherry picked only studies which strengthened their point... I'm so sick and tired of pseudo science and I also wanna mention that changing your diet in such extreme ways portrayed at the beginning of the video could also be placebo, shifting your focus on another part of your life
+Miriam Calypso i completely agree with you in that we should trust our health professionals. that being said, while his message may come off as "be skeptical of your health professionals", i think the goal was to "provide some thinking tools to navigate all the different information on health and medications popping up nowadays" as he puts it.
+Vincent Batchelor I have to admit that I wrote this comment rather impulsively out of a feeling of frustration, the claims in the video probably have their legacy and the research done isn't that much of pseudo science so I apologize for the generalization... however I still think that the message - not to trust your doctors who genuinely studied to get their degree - can to some extent be harmful
while it is fair to say that some of the arguments on the video are reductionist and one-sided, i tend to resonate with his view more than the view of the industry selling antidepressants. that being said, a youtube video isnt the best format for a well-supported and lengthy debate in a concise manner.
Not true that SSRI's are placebo, it is VERY VERY easy to test this, take Paxil 20mg for 6 months, then stop them cold Turkey, you'll see what happens to your brain chemistry, you will feel terrible, more than terrible. No in the past the people with depression would kill themselves, anti depressants can be a Godsend and save people from suicide.
i think thats just called antidepressant discontinuation syndrome. placebo and withdrawal are different things. also, not all depressed individuals are suicidal, and antidepressants can lead to suicidal tendencies too. would you want to take a medication that might cure you, make you want to kill yourself or do nothing much?
A doctor got really angry at me when I tried to ask what the drug she was giving me actually does. I wouldn't give up, since personally I dislike taking any drugs or medicine at all.
After belittling me, insulting me, and making my situation severely worse, she finally said, "I don't know", and added one final jab at me. I didn't take that drug. I had no idea what it was, I had no idea what it did, and neither did apparently she.
I don't know would've been a great answer, we could've looked it up and learned something.
Please can you make a video on probiotics, you really got my attention in your gut/brain video. The fact that weight and personality can be transfered completely freaks me out and can also explain why certain people never lose weight no matter what!! It is an incredible subject and needs more attention.
This video leaves out the last 10 years of research. Serotonin is a cause of inflammation. Inflammation is an inducer of depression. Changes to serotonin levels changes inflammation in the gut and immune response.
I’m not smart, so you should look it up yourself.
a bit reductionist, but in essence on the right track. i tend to stick more with: why should i trust research funded by the person selling me drugs telling me that their drugs are safe. that would be like a drug dealer showing you a paper saying opioids are safe. oh wait...
Is that quote at 5:09 correct ?!! ... Shouldn't it read something like, "headaches are caused by too much blood" ... not "too much blood loss" ... otherwise, I fail to see how any of that makes sense, even as an example of specious reasoning!! ?! Seems like a misquote/one too many instances of "loss" there, if you see what I mean ... ?! Cheers!
I just stopped taking my anti-depressants one day. I tell people that I consulted a doctor first but I didn't. I just stopped. I weighed the pros of its benefits against the cons of its side effects and made a choice. Not everyone is in a mental or environmental space to do that successfully and without harming themselves in the long run. The one thing I can say, and what I think a lot of people can agree on, is that combo foods that combine fat, sugar, and carbs: cakes, pastries, creams, syrups, breads, candies, etc. really do the body and the brain the most harm. If everyone were to just cut those kinds of combo foods out of their diet, the insulin spikes and other hormonal imbalances that these foods cause would stop contributing to the severity and longevity of depression. You can't change traumatic experiences or genetic predisposition but you can change diet.
My doctor started me Mirtazapine, a low dose. I moved back to England to care for my mother, leaving my 16 & 12 y/o children, behind. I was reluctant to take a pill as I thought I had every right to be sad and depressed and no pill would help that. I tried it for 2-3 months, initially my sleep was improved, a secondary reason she rx'd it. I felt draggy during the day, though and not as clear headed, so I stopped taking it. I know take numerous vitamins/supplements and sleep better and "feel" healthier, not really sure on that one.
This is misinforming. Medication is indicated only for major depressive episodes not all depressions. Furthermore one depressive episodes is not an indication for life long medication, the guideline after one single depressive episode is medication for 6-12 months. Even after one or two relapses you wouldn't have an indication for life long medication. By comparing depression with medicine to depression without, you are not explaining the obvious, that severe depressive episodes are way more likely to have a worse prognosis and way more likely to get medication. What is more, the chemical imbalance theory was an idea of the 70s and 80s. Today the main focus is brain metabolism, networking of the brain, and inflammation. This video like most of this channel relies on anecdotal facts, misleading and potentially harmful information.
Natasha Navotnaya I hate antidepressant and the fact that it turns people into zombies. Even worse when these people don’t even realize how their personality has changed.
But still I agree. I guess taking the risk of becoming a zombie is worth not dying..
I study psychology and have taken anti-depressants in the past before quitting them and continuing with some CBT, today I feel no depression or anxiety, so here's what I've learned about anti-depressants:
Antidepressants are exogenous chemicals that affect production and uptake of neurotransmitters in various different ways across multiple brain structures. In other words, when you take an antidepressant that decreases serotonin, you are not simply "decreasing the sad chemical", you are affecting how serotonin is used across thousands and thousands of neurons in multiple different brain pathways. Serotonin is a common neurotransmitter that your brain uses for lots of different tasks, not just mood regulation. Think of neurotransmitters like building blocks of your brain's communication, rather than chemicals that have specified functions.
What you eat also effects your neurotransmitters too.
GREAT great question! And that is one of the problems with the APPLICATION of the monoamine thesis (not the thesis itself!). The way it has been APPLIED focuses much too much on serotonin. This is partly because the drug companies came up with a slew of serotonin-related drugs, and of course wanted to profit from them. It is a whole complex story, but you're on the right track. The serotonin-ONLY treatment approach is off the beam for a great number of sufferers.
TLDR: we don't get how SSRIs work, but we still use them because there is evidence they do something that helps people. It is OK to use them to treat your depressed episode only the first time (ie for 1 or 2 months on the meds), but if your doctor recommends you go back to them if you have another episode, be very critical and make sure it is absolutely necessary before you do.
Interesting subject. Sadly I'm one of those on antidepressants for life, it's pretty annoying but better than how I feel without them. I definitely think that for some people they're prescribed too readily, but it's a cheaper and easier option than proper therapy. I hope something better comes along in my lifetime because I still feel broken on the tablets, they just stop me from wanting to die so much. Diet is an interesting factor,and I believe other features of modern life contribute to the cause.
the thing is maoi lower 5-hiaa levels because of breakdown so its def not perfect similarly breakdown metabolites of dopamine hva and adh are not indicators of dopamine levels because come and Mao break them down and can in fact be a sign of low dopamine, norepinephrine because of fast break down especially with someone with high activity Mao or come enzymes , in fact its this gene comt that is often used to be tested to see if the patient may benefit with stimulants and it is comt along with mthfr (folate gene that helps synthesize sam-e, dopamine , norepinephrine, serotonin) that predict depression symptoms , as well as negative symptoms in schizophrenia (which mimic those of depression)
i've been on just about all the SSRIs that the pharmaceutical industrial complex has to offer. i couldn't tell what did what, if anything at all, except give me horrific... absolutely life-destroying side effects and withdrawl symptoms.
I wish I had never been put in antidepressants. I was put on them in my sophomore year of high school by my general physician (Paxil, while on Accutane, which was not okay to combine). I now take 40mg Prozac every day and I struggle with depression chronically. I want to be a happy person. Even when I was having a very happy time in my life last winter, I wanted to be taken off my medicine. I was tapered off, but became so immensely suicidal and depressed I had to resume. This happened every time I tried to quit my meds in the past. And now I'm on 60mg of Vyvanse to keep me awake every day, since I now have Narcolepsy.
Anti-depressants have saved people's lives. but you know, meh, that is out of the scope of this video. Well that detail you are leaving out of the video is the only thing that actually matters in this whole topic. They don't work for some people, but they DO work for countless of people and have been life saving in countless situations. Are anti depressant perfect? No, but they seem to be the best we have right now
Melmano Yes. Because the people who are the most disturbed are the most likely to both
A- need and get antidepressants
B- perform acts of violence
Prior dual causality is the perfect example of non casual coincidence.
depression and suicide rates are increasing, so i would argue SSRIs are not enough. And there are better options on the horizon, the FDA recently granted psilocybin and MDMA breakthrough therapy status for depression because they perform so much better than SSRIs and therapy.
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.