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Antipsychotics, Mood Stabilzers Anxiolytics

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SKIP AHEAD: 1:01 – Antipsychotic Mechanism 1:58 – Antipsychotics and their Indications 3:30 – Neuroleptic Malignant Syndrome (Typical Antipsychotic Side Effect) 4:18 – Extrapyramidal Symptoms (Typical Antipsychotic Side Effect) 6:19 – Atypical Antipsychotics and their side effects 8:57 – Mood Stabilizers 12:58 – Anxiolytics and Benzodiazepines We will start with a quick review of some material from my previous video on psychosis. Symptoms of schizophrenia can be broken down into 2 categories, Positive and Negative Symptoms. Positive symptoms include behaviors or sensations that are not normally present. Examples include hallucinations, delusions, and catatonia. These symptoms are thought to be related to an excess of dopamine. I remember this by remembering that “doPamine has a P in it”. So P for Positive and P for Dopamine. Negative symptoms are the absence of normal behavior. Examples include a lack of initiative, diminished speech, disheveled appearance & flat affect. These symptoms are thought to be related to an excess of serotonin. As we will see antipsychotics affect dopamine and serotonin to varying levels. The indications for this class of drugs includes psychosis (mainly schizophrenia), Mania (mainly bipolar disorder), aggression and Tourette's disease. Typical Antipsychotics primarily block dopamine receptors in a non-specific manor. Therefore, these drugs work best for positive symptoms, and have little effect on negative symptoms. The non-specific mechanism of the drug also means there are lots of side effects. Some of these medications come in a slow release injectable form so they can be used in non-compliant and aggressive patients. There are a lot of high yield side effects so we will break them down one by one Neuroleptic Malignant Syndrome (or NMS) is a rare but potentially fatal adverse reaction of typical antipsychotics. It involves fever, altered mental status, rigidity and autonomic instability (such as tachycardia, hypertension, diaphoresis etc.). You may also see elevated myoglobin in blood or urine and elevated Creatine Kinase (CK). One of the ways I think about it is that it looks kinda sorta like Serotinin Syndrome that you can see with antidepressatns. If you see this you have to emergently stop the medication, provide supportive care and consider adding Dantrolene Extrapyramidal Symptoms (or EPS) are due to blockage of Nigrostriatal dopamine. It can present with a number of different symptoms. Akasthisia is a general sensation of restlessness Acute Dystonia is involuntary continuous muscle contractions often of the neck. Another common presentation of acute dystonia is Oculogyris Crisis when your eyes get locked looking upward and you have to lean over to see Dyskinesia (AKA Pseudoparkinsonism) presents like Parkinson’s Disease with symptoms like a pill rolling tremor, cogwheel rigidity & bradykinesia (or slow movement) Tardine Dyskinesia (or TD) is uncontrollable facial tics, grimacing & tongue movements As scary as these symptoms may look, they are generally not medical emergencies. In most cases you will continue to use the drug with perhaps a reduction in the dose or the addition of an anticholinergic mediation like Benzatropine or Diphenhydramine. Tardive Dyskinesia is the exception and requires cessation of the medication as it can be permanent. Usually you would switch a patient with TD to a 2nd gen antipsychotic. Hyperprolactinemia is a side effect due to Blockage of Tuberoinfundibular dopamine. It presents just like any other disease that increases prolactin. So you can have galactorrhea, gynecomastia, decreased libido and menstrual irregularities. The text for this video is too long and exceeds Youtube max allowed length. To read the rest please go to http://www.stomponstep1.com/antipsychotics-mood-stabilizers-anxiolytics-benzodiazepines-tardive-dyskinesia-extrapyramidal-symptoms/
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Текстовые комментарии (24)
March Marchie (22 дня назад)
Thank you ,sir.. it was awesome and understable...it really help me a lot to be ready at my new job to understand the patient way and thinking....god bless you..sir...
Oil Artworks (10 месяцев назад)
Benzos can be used for status epilepticus. I want to see that. Have you made it?
Harlucie@gmail.com harryman8269 (1 год назад)
This video helps me a lot thank you very much sir
David Billyard (1 год назад)
Chemical lobotomy ...
workouts (1 год назад)
i cannot understand why serotonin excess causes negative symptoms..like unhappy symptoms.. when we treat depression or else we give ssri which increases serotonin action..and it is known as happiness hormone..can u please explain?
Monica Havemann (1 год назад)
Schizophrenia has nothing to do with the dopamin hypothesis/ myth and depression, nothing to do with serotonin. Psychiatric drugs very quickly cause a chemical imbalance, shrinking and damaging your delicate brain, and shortens your lifespan.
The meditative monk Mediator (5 месяцев назад)
Monica Havemann this folks is what you would call someone a slut with child support payments debpt. Lmao
Celestine Mpiri (7 месяцев назад)
Your comment is just s•••id
adam parker1 (1 год назад)
whats your theory on it? genuinely interested.
fawaz Almuwayshir (1 год назад)
What's your evidence?
Luis velez (1 год назад)
Thanks
mother goose (2 года назад)
Hard to find out facts on drugs so a person can try to maintain one's health as well.
larry jdd (2 года назад)
Hi! Helpful video I have two questions Are there any side effects to buspirone, such as insomnia? Do the side effects of TCA such as cognitive impairment go away? Thanks
Virendra Agrawal (2 года назад)
very useful for seniors like me. it's a recall and add in daily practice
Katja Bulavkina (2 года назад)
Greetings from Latvia! Thank you very much for this collection of videos! I would only suggest adding some childhood/adolescent disorders to this list (ADHD, Autism, mental retardation and learning skill specifics as dyslexia, dyscalculia). :) Very nice revision material for the exams :)
Nic Miller (2 года назад)
You're a legend, man. Thanks for this series, UWorld was killing me!
Stomp On Step 1 (2 года назад)
+Nic Miller LOL thanks!
Jaime Maussan (2 года назад)
Thanks!!!!!
Stomp On Step 1 (2 года назад)
+Chux “PLUR” Thomas thanks for the comments! It really helps me out
haroon saadat (2 года назад)
Thank you so much sir your awesome best explained ever
no way no way (1 год назад)
+Stomp On Step 1 mood stabilizers are pure poisons whether like it or not.
Stomp On Step 1 (2 года назад)
+haroon saadat Thanks for watching!
lucycare (2 года назад)
Great video! ♡♡
Stomp On Step 1 (2 года назад)
+lucycare thank you for the kind comment :)

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