Dextromethorphan (DXM) is a dissociative with a more complex pharmacology than ketamine and PCP. In medicine it's been used for cough, pain, pseudobulbar affect, and a variety of other conditions. It's also a fairly common recreational drug.
TDC Overview Page (with references): https://thedrugclassroom.com/video/dextromethorphan/
Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/907ajm/dextromethorphan_dxm_what_you_need_to_know/
00:23 - Effects
13:29 - Medical Effects
18:25 - Pharmacology & Chemistry
21:16 - How It's Used
21:40 - History
24:58 - Legality
25:11 - Safety
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I reached plateau sigma my freshman year of college I probably consumed around 2000-2500mg of this shit within a week. With constant small to large redoses. Shit was crazy. Here I am almost a year later stuck in this depersonalized trance I cannot get out of. Shits weird I feel like I am the only person who's truly here. For a month after the trip I kept thinking that what I was seeing was really just my imagination and I was actually in a coma. Shits crazy man. It'll fuck you up. It'll fuck you up good. Don't do this shit. If you really want to know what it feels like just go to Reddit and read others experiences.
Bruh I took exactly 100 mg from a delsylm bottle, waited, didn’t work. Took a full cup (about 20 ml or 120 I think) waited, didn’t work. I’m too scared too take more. Do I have some sort of genetic trait that can handle substances better (this is my first time ever taking it)?
The first time I took DXM(Triple C’s) I took 6 pills and it was great. It was to the point where it clicked and I knew what I was doing and I having a extremely time doing it. I laid back in my bed and my whole body went numb and it felt amazing. I had my friend who smoked weed before as a trip sitter in case anything happened. I’m not addicted to it, but I would recommend taking a small dose of it and it feels great.
I have severe OCD and depression, ssri's, Antipsychs, Benzodiazepine never worked for me. I once tried 60 mg of DXM but it did not affect me and i'm thinking of trying it again upping the dose a little to see if it could help with my intrusive thoughts.
the only time I do Dex is when I have pot on me. It enhances the trip 10 fold🤩. This drug can be very addicting if you fall in love w/ the feeling. Definitely my favorite thing to do is produce music while I’m zoned . Time seems to not exist. I also like going to the gym on DXM. Drive around smoking a blunt, while tripping is amazing, but dangerous!! xD. Overall this drug is bliss. Definitely a must try w/ weed. But becareful. I usually feel somewhat down the next day or two after doing it & it makes me want to trip again to uplift my mood. jus don’t become addicted & you’ll be good.
DXM is so lame! Ugh I got stuck in the loop of robotrippin for a spell lol it was not fun had the flu and wss like fuck it even tho it didn't help it makes u care a lil less about being sick but yuck I hate how it feels especially when they mix it in to cut mdma smh wtf jyst no no don't
I have a buddy who became seriously addicted to this shit. It ruined him; his body, his mind and his spirit are forever tarnished because of the massive amounts of DXM he ingested. I'm talking well over one hundred gallons or more.. Years and years of hopeless abuse has most likely riddled his brain with lesions, as he just isn't the same person anymore. It's sad because I miss him, the old him, the kid that was so clever, funnyand full of life has been diminished to a brain damaged husk of a man.. I'd like to think that if he could stay sober long enough, that the old him would come back, but I know that's probably just a pipe dream.. .
¨fuck what they say. DXM is number 1 ingredience in this world. HEll i did 1000mgs, 800mgs,600,... hundreds and hundreds of dxm trips i had. I already finished but the times it was just psychedelic multidimensional meltdown. Sometimes i even felt like being acid myself :D
I've taken 1700mgs of delsym and smoked a bowl and I've never had anything more intense than a plateua 2 or 3 by what this guy says. I only dissociate and listen to music. I just float around in my mind and that's it. Maybe a slight OBE
I'm around 110 kg and took 900mg and had a complete out of body experience, as if my mind and body were traveling to other dimensions while I was an observer sitting inside my head. I was completely dissociated and detatched from my body. I remember having voices in my head telling me to kill myself to end my nightmare experience while I watched the clock stand still. The time literally stayed at 10:15PM for hours. Set and setting is VERY important with this drug.
Last thing I remember from my last DXM "trip", I drank the bottle, puked, had a good time smoking some weed and BAM anxiety attack. Everything was flat (stairs were a challenge) lots of confusion. And felt like I was dying and not myself at all. DONT DO IT MAN JUST WAIT AND FIND SOME MUSHIES OR CID
I took 1200-1400mg one time, I would always take these boxes of the pills. They had guaf in them but it didn't typically make me nauseous so I was fine with it. Honestly I don't remember much of the experience expect for watching trippy videos and just being so stupidly out of it that I couldn't even talk, I would slur every word that came out of my mouth. I was with some friends and we watched the music video for Cartoons and Cereal by Kendrick. That shit is so nostalgic now lmao.
Edit: I just remembered some funny shit, one of my homies thought he heard my brother wake up, so for like 20 minutes straight he kept going "shhhhhh" without any explanation. He was in another fucking world.
I would add...As with ALL drugs, it greatly depends on other chems already in your system. This includes food, vitamins, minerals that WILL react (good or bad) or change the chemical makeup hence the different experiences. Do your Research !!!
It's a primary intended effect of recreational use, which is what "positive" means in this case. But like with many of the core aspects of hallucinogens, dissociation can sometimes be a negative, which is why I mention the importance of individual differences.
DXMs stimulating at around doses of 400 MG. 700 MG is when its sedating. I use to take a bottle and a couple adderalls and go mountain biking. It helped me excsersize. I lost a lot of weight quickly. I looked great.
Dude, please avoid combining stimulants at all with DXM. Caffeine MAYBE is okay but adderall is a no.
Adderall causes neurotransmitters to dump from the synapses whereas DXM prevents them from leaving the area. It causes overstimulation all over the body. It's dangerous on most of your organ systems to take these together due to the hypertension and tachycardia.
Even taking DXM two days after the last dose of adderall could be a very negative experience.
I took DXM a day after taking a dexedrine, and smoked weed during the experience. I was late on a dose of my blood pressure pills. I had extremely intense chest pain and a panic attack. It lasted for 3 hours until I took extra clonidine and benzos. I didn't want to end up in the hospital because my brother was in town for the first time in a year and was leaving the next day. I had an EKG done two days later and the findings enabled my doctor to tell me that I probably had a heart attack and I have a cardiac stress test next week. I'm in my 20s, not in my fifties like my late father who had a stress test a week before he died.
In other words, please be careful man.
Seth, what do you think about the latest "Huge New Global Study" that revealed that any amount of alcohol is bad for you and what implications do you think this will have in the future in terms of how that will effect the current and future drug climate not just for alcohol but for all other drugs as well since alcohol isn't being seen as so innocent anymore?
I'd like to get one of the study authors on the podcast. The effect size at low-moderate levels of alcohol use is not massive, so I don't think it reveals anything too substantial. The research has been oscillating between moderate use being somewhat bad or somewhat good for years.
And it's always unclear how much alcohol itself is to blame, especially at lower use levels. The lifestyle of a non-drinker vs. a drinker is likely different in various health-related ways that have nothing to do with alcohol, so when a somewhat higher risk of disease or death is seen, can that clearly be blamed on alcohol? Even if it can, the relatively small elevation in risk has to be considered in the context of the socialization and relaxation benefits some people get from alcohol. Drug use is nearly always a pro/con game and mere enjoyment can justify use in a lot of cases.
With all of this being said, I don't think the study changes much and there aren't many, if any, shocking revelations in it. I just hope that everyone can remember that just because something is somewhat harmful does not mean it has to be strictly regulated against. We're fine recognizing that with food and less fine recognizing that for drugs.
very strange drug.my brother took 200~1000mgs of this stuff many times. but couldn't get any CEVs.that means DXM CEVs not for everyone.some people hate this drug.for me it is the king of CEV.i have used most of drugs including LSD and MDMA.but DXM CEVs are the best.they are extremely vivid and real.and the body high is massive. music sounds great.when i listen to music it makes the best and most suitable video for the song in my mind.feels like i am the music.there are many things happen like having conversations with music or with the god or with my own mind.sometimes i feel im the one who has to save the world.they are 100%real when i am on DXM.CEV mode is pure meditation mode for me.start to think about reality of the life. then i could understand it many times.i have a lot of things to talk abt dxm.unfortunately my English knowledge is not good enough to explain.anyway id like to say DXM is the best drug i ever had.at least for me.
Jeeeezus you make it sound so dangerous. DXM is one of the most innocuous psychoactive substances I've ever used. I've only ever combined it with LSA which was incredibly intense, but on its own I typically took 450 or 600 milligrams depending on my plans, and took 900 milligrams once. I never once felt panicked or delirious. I know that's only my subjective effects but through all my 10+ experiences it was never once close to the severity you portray. I only ever danced for the first hour, followed by four more hours of laying down and experiencing very fun closed-eye visuals or vivid daydreams with distinct narratives, such as when I believed I was in the Avengers.
I don't consider it very physically dangerous nor is that what I claim. DXM is usually a physically safe substance even with heavy use and it is minimally linked to fatalities or life-threatening overdoses. As to psychological issues, those are widely reported in the scientific literature and by users online, so I don't think it is misleading to note a connection between high doses and paranoia, confusion, etc. Just as people can go through many experiences with psychedelics without once having a "bad" trip, the same is true for DXM, but that does not change the existence of those negative effects, it just means they are highly variable between individuals and uses.
Of course the video was excellent regardless. I left a like. Because you do such great research for your videos and this is one of your most comprehensive guides. Any other viewers reading this ought to take my words with a grain of salt. Listen to the expert.
DXM Made me feel like I was in a different place inside my head. When I would close my eyes it felt like I was in a big black space, and a floaty almost 3rd person feeling when I would walk around (not fun to do really, its not a walk around type substance in my opinion). That was at 400~500mg. On my most intense trip I was transported to a different place. Its like I was seeing through the eyes of a bug and was in a house, flying around. There was a man who looked like someone you would see just at home, being comfortable (White tank top with sweats). I was in a hallway sort of thing and the light was pretty dim (think, older lighting. Yellowish tint) and the walls were wood panels. he walked through a door into a dark room with a tv on on the other side and when he entered I got blasted into a weird vortex and I dont remember much after that. I slept (basically tripped the first half it feels like) like 14 hours.
It was a cool experience. Definitely made me question life more than I do now. I would never do it again though, it gave me heavy visual snow for a very long time. Partly because I abused it for a month straight tripping every other day and , but im just letting you know so you all can be safe. The dissociation is addicting when you are curious and bored.
Be careful with this weird substance! It's definitely strange!
Some products contain "Dextromethorphan hydrobromide monohydrate" instead if just DXM. But from what I have heard, they are also used recreationally. Is it okay to use such products in the same way products with just DXM are used?
Started fucking with dxm when I was on probation. Highest dose I’ve dropped was only 700mg delysum. I like to mix it with other drugs around the 300-400mg range. I’ll drop a 1500mg some day, that shits gonna be scary cause I was completely out of it on 700
Dxm 3ed Plato with a hint of alcohol gives me fucking super strength dxm 2ed-3ed Plato an alc an weed makes me feel like I’m losing my mind in a good way sometimes lol 4th Plato nothing but dxm had me so high I was like a retarded baby I felt like a potato that was one with everything dxm best way to describe it is just one big confusion I never know wtf is happing on it even if where just chillin hope this helps ;)
FYI- you can overdose on it easy if you cross fade an I’m not a beginner ether so every one is different
Here's a tip from a seasoned tripper. You don't watch a movie on DXM. Or fuck around on video games. DXM isn't a visually pleasing drug. For a rewarding experience at a low dose, it's all about the auditory experience. On the come up, darken a room completely. Cover all windows and light sources... No phones. Lay on the floor and put on a continuous playlist of music. (If you're alone, lay with the speaker pointed directly at the back of your head). With this kind of sensory deprivation you will connect with songs on an otherworldly level... Almost like you become the essence of the song. It's difficult to explain, Every nuance in a songs will utterly amaze you. Though out the trip someone will say something out of the blue and it starts profound conversations. Single statements can make deep impressions on you. Like nuggets of wisdom that will stick will you. It's truly an educative experience when taken to expand the mind.
DXM is one of those drugs people take because they cant get the good stuff, i don't mean to say that ketamine is good but its shorter duration and higher saftey profile with increased recreational effects make people prefer it
+CherryBomb bruh I went in my closet then it grew a million times bigger and I couldn't figure out how to get out so I explored it , and it was fucking awesome also when I sat on my chair I flew away to another world
Datura Stramonium, a nasty ass deliriant shit that can be found near the roads. Its effects sound pretty interesting but its toxicity sounds pretty scary. https://en.wikipedia.org/wiki/Datura_stramonium
Edit: I was watching the deadly nightshade video and it looks very similar, I think that even the active compounds are the same.
Did someone make that claim? The closest to that claim is that mystical experiences are more common with common psychedelic doses vs. common DXM doses, which is a statement of probability, not possibility.
I took this stuff a couple days ago and oh boy was it interresting. I did almost everything wrong that you can do wrong when taking a drug, I didnt research beforehand, I didnt know the dose i was taking and I didnt really even know what to expect. Long story short, I spent the whole night sitting in a porta potty, shitting out water and enjoying it. I dont regret it but i sure as hell wouldnt do it again.
Possible to use DXM as a substitute for ketamine infusion depression treatment? How about other ket analogs like deschloro? Like a poor man's treatment resistant depression treatment? I have found DXM to be helpful in my anxiety and depression at less than 80mgs, daily.
Sitanshu Nandan blah blah blah shit the fuck up didn’t read your whole response i survived that shit bitch and experienced things that were amazing and other worldly not looking for some moralist bullshit from some one I don’t care about or know
Drink a whole bottle of vodka everyday for three months and talk to me about the effects.
There's a major difference between recreational use and abuse of drug.
Abuse of any drug is detrimental to one's health. That's why we have safety guidelines.
Doesn't have to be bromism as a diagnosis to be affecting you. Bromide can lower thyroid function but not be clinically diagnosed as the cause. Especially if one uses other substances which depress thyroid function such as alcohol.
There's no indication DXM is typically an issue in that salt form or that other common HBr medications are an issue at commonly used doses. There are next to no reports of DXM-related bromism despite its use for decades.
Interesting to hear that DXM could help with bipolar disorders and depression. I believe it, because when I'm on it, it helps calm down my delusional thinking and mania-episodes, so I believe it could work in treating those conditions!
I do need to add to comment earlier by saying I did not mean your vids are inaccurate I got mad respect for what you do and love your content I meant solely that the research you found has been diluted by people just getting the what I would consider to be low dose at the highest plateau you mentioned. I think your mind and spirit could take much more if you’ve dabbled with it not sure about most though you have to trust a drug to a degree to enjoy it and DXM is very safe comparatively.
You need to do a dose dude this is inaccurate due to people’s tiny doses I’ve done most every psychedelic and this is by far the one I’m most familiar with and I’ll tell you this when on a truly substantial dose you go out of body no matter what and that thing about time you’ll live 1000 years in a night it’s the most beautiful unexplainable feeling I’ve ever experienced and do in the darkest place possible on your bed and listen to certain music because noise can be distressing if it’s wrong but you spend hours it feels between each note and a song seams to be a year or so in the sense of your travels and visions and but it never feels old or boring unlike time very odd thing with the time aspect try not to have any light even your phone or whatever playing the music cover it up lay something over your eyes if you want light reduces where you can journey visually. If you plan on having your eyes open and having the true experience you won’t but it’s still fun even at the dose far greater than the plateau you speak of when you want to open your eyes and piss or smoke change music or whatever you got to do it’s Trippy and strange sorta like a moderate mushroom experience it’s when you close your eyes that you experience the thing that always brings me back to this compound there been shit that no one would believe and I don’t blame you being that I’m a random dude talking about a drug but I’ll explain one very mild compared to the ones I’ve been on solely because of it was still of this world but I was laying in the back seat of my brothers car after him and his girl told me we needed to go somewhere and I’m already layin in bed out of body seeing all sorts of whatever but I had my eyes covered with a few black shirts even though we were driving at night light pulls me back from where I want to be but anyways I already knew that little trick so I’m back there and I am completely in sync with the speed of the wind above the car just could see my body my bro his girl if I came back in but I would go above the car look forward and ask my brothers girlfriend if that’s this place or that place in the city and amazed she kept telling me I was accurate 100% and she wasn’t lying somehow I was out of body above or around the car feeling the wind as if I was physically there as well almost like what imagine a ghost would feel yet feeling comfortable as can be because I’d been stranger places before and if I’m seeing things of this world I know I’m not going to die worry I took to much because normally I’ll end with the comedown coming back to earth then around the room or whatever then start the whole coming out of it thing but the whole time i was comfortable and knew whatever was around but I’ve never stayed in sync with the speed of my body moving in a vehicle normally I’ll go away from my physical self or body whatever and not come back till the comedown but this time it’s like I had to keep up with where my body was traveling and asked questions to see if I was really seeing things correctly and was it sounds like complete bullshit saying it if you’ve even read this far haha but damn what a drug! NEVER take any moderate to high to massive dose if it has acetaminophen or any other drug in the syrup or pill that’s how people die not from the dextromethorphan.
Honestly, I have a CYP2D6 deficiency, so the fact I enjoyed it at all says a lot about my mindset. I am more of an opioid fiend, but the biggest thing that got me to stop THAT is just all the negative impact it's had on my life. It's nice to THINK you can just get high and go handle your business, but once you start, you always want to be just a little higher.
This is legal, and could possibly be very dangerous especially if used incorrectly, and we got pot over here... schedule one no medical use.. That's not a good message I don't think, I think kids try to do this for a high because weed isn't legal
What are you talking about having no medical use? Both DXM and cannabis have excellent medical uses in addition to their recreational qualities. Responsible adults should not be criminalized just because irresponsible adults who don't know how to raise their kids, have children that hurt themselves doing stupid things because their parents didn't teach them properly.
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.