Thank you for this video, a good summary and differentiation of these classes of drugs. Although I have one confusion. I thought fondaparinux does bind to anti-thrombin and potentiates it's activity in inhibiting Xa more than LMWH. If not how is it different to direct Xa inhibitors? This video states that Fondaparinux binds directly to Xa.
I'm confused as well. My professor taught it as it forming a complex with antithrombin 3 and being selective for 10a (wikipedia confirms too). But this video and another video I watched says it binds directly to Factor 10a.
Oh my god! I was literally waiting for the upload of video on this topic. Sir, You make learning process in pharmacology so simple and easy to understand. I owe all my good marks to your lectures! Thanks a ton❤
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.