Mirtazapine is a tetracyclic antidepressant in the NaSSA class. It has a similar efficacy to SSRIs and TCAs, and it may be a better option for certain populations.
Some recreational effects like euphoria, CEVs, enhancement of cannabis, and dream enhancement have been reported at certain doses. It's not clear how reliable those effects are.
Overview Page (Including References): http://thedrugclassroom.com/video/mirtazapine/
Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/4zqaeb/mirtazapine_what_you_need_to_know/
Mirtazapine: Remeron; Avanza; Zispin
PsychonautWiki Page: https://psychonautwiki.org/wiki/Mirtazapine
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I absolutely live Mirtazapine, I live feeling like a newborn when I go to bed at night. You sleep so god damn good and I have closed eyed visuals too, its like a weed high but without being high? I got the munchies real bad on this, Ive gained alot of weight but I dont mind it since im 6'2 so I look pretty much the same after gaining 20 pounds. It does cause severe drowsiness; you could wake up and still feel tired. It does help with ny anxiety and depression, but I dont feel happy just nuetral, its better than having anxiety attacks and suicidal thoughts in my opinion. It dont really have motivation on this since you just feel tired all the time even if something you enjoy doing. But all in a best anti depressant and anti anxiety out there.
i am taking 45 mg and i take valium 5 mg its affecting me to work has any one else experiencing this please message me back i find it so hard to get out off my bed and ive put on so much weight i was 100 kg and ive put on 45 kg i am 145 kg now i find it so hard to even go to the bath room and shave please get back to me and let me know if you guys having the same problem . and if i don't take them i get so angry i had to go to anger management . i learned few things but with out my medication i think the hole world is against me and i am so angry . so i have to take my bedicatin it works but the side effects of putting weight and i cant even go to the store to bye my shopping has any one eprince the same way please let me know .
I’ve just been prescribed this to help with my sleep and depression.
I’m a little concerned about the side effects. Especially the increased appetite and weight gain. As I’m already classed as overweight.
So I’m having second thoughts about taking it.
Any tips from people who are currently taking this?
This is very popular in County Jails and prisons, particularly in detention centers that have banned Quetiapine. Helpful to those looking to sleep away their time. However it seems get certain people completely wired. But it's heavily sedative for the most part. It does have some psychoactive effects however. I've never done enough to really explore it as I just needed sleep, but I did notice that when it would begin working I would a experience an odd, somewhat relaxing but almost disassociative kind of buzz that would last for about 60-90 minutes before shifting into sedation.
I did witness a few inmates crushing tablets and insufflating them, but then it IS jail after all, and people are fiending for any kind of a head change they can possibly find. So I can't speak to whether or not it provides a more recreational effect or not.'
Extremely dangerous lemme just tell you that. Took this like 6 months ago from the doctor, couldn’t stay awake but kept seeing bright flashes when I closed my eyes, realised it wasn’t right I tried to go to the toilet and kept falling on the floor. Fell down the stairs trying to get to the phone.
I'm having chronic sore throat and have zeroed in on mirtaz. is there any alternative to Mirtaz and with minor weight gain and that will not cause sore throat?? any info will much appreciated. (been taking this on prescription)
Mirtazapine's lack of suppression and possible increase on REM sleep is just a consequence of Mirtazapine's inability to increase serotonin in the brain, specifically in the (D/M Raphe Nuclei), and this is countenanced in numerous journal articles dealing with the pharmacology of sleep. Mirtazapine's effects of any note are at H1, a2, 5HT-2C and 2A. Antagonism at H1 creates drowsiness and diminishes anxiety, at 2C staves off nausea, at 2A CNS activity, which adds to the anti-anxiety effect and is precisely why Mirtazapine was used in a convincing case report to reverse Serotonin Toxicity.
Mirtzazapine isn't an anti-depressant, but can quell anxiety if the patient can tolerate the side effects of fatigue, weight gain and sometimes increased BP.
You almost lost me at "pretty unique", but I battled through. Mirtazapine is in effect principally an older class antihistamine, with a heck of an impressive H1 receptor affinity of 0.91 nM. That Mirtazapine is even classed as an anti-depressant is a modern miracle of big pharma. Let me hedge a little and say that there's no doubt that sufferers whose primary symptom is anxiety (think of mixed anxiety-depression) are helped by this drug, but it's not an anti-depressant, and in fact makes some symptoms of depression worse. People with endogenous depression will need something else, or a stronger adjunct medication to get to a higher level of functionality, possibly even a stimulant considering their level of fatigue on a moderate dose of Mirtazapine.
Of course, people with reactive depression are helped by just about any drug, even a placebo, and these patients make up the majority of new patient visits to psychiatrists' offices.
The claim that it is not an antidepressant would need to pretty well-referenced. Although there are issues with the way clinical trials are run in general and how they're run in depressed patients specifically, the available evidence shows antidepressant effects. If you have a bit of published evidence demonstrating it makes depression worse more often than it improves depression, feel free to share it.
PLEASE READ THIS BEFORE TRYING MIRTAZAPINE.
This can be a very effective medication for people who have PTSD, I suffered/suffer from severe PTSD and did not respond to the multiple medications i was prescribed....Eventually i got sick of these so called "doctors" using me as guinea pig for their money grabbing prescriptions and went and got a third party hormone test, cortisol, adrenaline, norepinephrine, testosterone etc (you get the jist) and it turns out that i have extremely high levels of cortisol and adrenaline with lower serotonin and norepinephrine.
After much research i discovered that during the testing of this drug it was shown mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors which allows for the reutake of serotonin and norepinepherine but to a lessor degree so its not an SSRI. It acts but dialling down the hypothalmic pituitary adrenal axis (HPA) thus acting as an adrenocorticotropic hormone (ACTH) antagonist (It lowers cortisol and adreanaline) and has been shown from tests to have this effect from the VERY FIRST DOSE.
Right the thing i want to share is that it is very probable to get the therapeutic effects from this drug WITHOUT the need to take it daily. i was in a pit of despair with suicidal, violent tendencies due to repeated PTSD episodes...Basically i was fucked but then after all the bull shit with the docs not having a clue what they were doing i decided to do my own research and discovered various papers on mirtazapines modes of action and decided to take 15mg of mirtazipine once to see if it really would lower my adrenaline and cortisol after one dose and guess what? It did exactly what the case study had said it was shown to do. i did not take another dose for 7 days and they were the first 7 days in many years that i HAD NOT had any major PTSD episodes....there were minor ones but they were easily managed whch had never happened before.
I slept more soundly than i had done in years and the effects lasted well into the following few days with a dramatic decreases in fight or flight episodes, i did feel a bit spaced out to begin with but this was nothing compared to the hell myself and many others with PTSD suffer with. Here is my word of warning about this drug, People should keep in mind that although medications are created to treat people with many varied illnesses there is also a very large emphasis on profiting from the creations of these drugs and very often will be prescribed in excess of what patients may need or want in the search for sales.
Because mirtazapine was able to lower my adrenaline and cortisol down to healthy levels from the first dose of 15mg and had lasting effects on theses hormones days after application i found it NOT necessary to take mirtazapine daily or even weekly but only as needed.....This is an extensively important discovery for myself and possibly many others.
I find that i use mirtazapine any between 1 to 4 times a month at 15mg to 30mg and at times not at all . An important thing to understand is that people that suffer with PTSD often have higher than normal levels of cortisol and adrenaline which puts alot of stress on the endocrine system and the whole body which simply put, Can burn you out. be cautious of following a doctors recommendations for dosing with this drug as i found it IS NOT NECESSARY TO TAKE IT EVERY DAY. Why form and addiction to the drug and risk potential warning effects from OVER USE and withdrawal when wanting/needing to stop. I am fortunate as my past experiences with incompetent medical practitioners and an understanding of chemistry and biology ensures that i spend much time researching any new treatment i am interested in regards to diet, work, medication etc.
I MUST STATE THAT I WAS NOT ON ANY OTHER MEDICATION WHEN I TRIALED MIRTAZAPINE...QUESTION EVERY THING AND NEVER TAKE ANYONE'S WORD FOR IT ESPECIALLY WHEN IT COMES TO YOUR OWN HEALTH AND LONGEVITY, BIG PHARMA ARE A GIANT MONEY MAKING COOPERATION, DONT BE FOOLED INTO THINKING THAT YOU HAVE TO TAKE ANY MEDS, IN FACT DO YOUR OWN RESEARCH, EAT WELL, GET THE RIGHT SUPPLEMENTATION AND TRY TO RELAX. DIET IS SOMETHING THAT SHOULD BE ADDRESSED AS I HAVE FOUND THAT BAD DIET AND LIFE STYLE TENDS TO BE THE BIGGEST CULPRIT FOR MENTAL AND PHYSICAL DEGRADATION. The infrequent use of mirtazapine has given my mind, brain and body the rest it needed from adrenaline and cortisol so i now have enough mental chill time to work through the demons in my psyche. I hope this wasnt too long winded and that it can help others as it has helped me...Take it easy and stay groovy people. And thank you "The Drug Classroom" for all the info you post.
We each have a different genetic profile, so we all react to medications differently. What works for me and Jedi might, or might not work for you. Therefore you have to be cautious accepting advice from discussion forums like this. But I will also say that when you find really smart posters like Jedi you should carefully consider their words because often they will know more about the subject than your doctor.
You are more than welcome, Im glad that there are others out there that can benefit from self experimentation and you are absolutely right that this drug does not need to be used daily and it still baffles me that doctors religiously stick to the "depression is serotonin based" depression/ptsd/anxiety can be symptom of individual or combinations of serotonin, dopamine, nor epinephrine, epinephrine, cortisol, adrenaline, testosterone etc regulation problems brought on by many different causes from diet all the way to too much masturbation. If you dont mind me asking how did you come to realize that mirtazapine worked this way?Thank you for sharing so far, up till today i did not know of any one else who uses mirtazapine this way and the doctors absolutely refuse to acknowledge my claims despite having third party blood and urine tests to back up the results prior too, during and after dosing. Be well
Thank you for your most helpful comment Jedi Mind Trick. I also use Mirtazapine the same way, I use it as needed on a 'one off' basis and not as a drug to be taken every day. It seems to have an effect for about a week after you have taken the one dose. This affect can slowly wane, or if you are not under stress and pressure can last for a month or more. Sometimes you need to use it twice in a week if you are stressed out. But to take it daily means that you suffer the horrible mind-numbing sedation and over-eating side effects needlessly. There is no discontinuation syndrome after a single dose. You can stop it immediately without any problems. Readers need to understand that this drug works like no other on PTSD, Depression and Anxiety. It works IMMEDIATELY, within an hour of taking it on an empty stomach and it works very strongly to bring you out of your depression, anxiety, or whatever ails you at the time. Other Antidepressants can take six to eight weeks to work. Not this one. This is instantaneous. It works so quick that I don't understand why doctors prescribe anything other than Mirtazapine. Why wait eight weeks for a drug to work when Mirtazapine can do the same thing in sixty minutes?
They say Mirtazapine only takes about 3 weeks to work, it definitely took a good two months for me to notice any mood improvements. It works pretty well as a motivational aid for me too, the only thing that bothered me was the weight gain, the appetite stimulant effects disappear after about a month though. This only made me more motivated to join the gym and I feel a lot better than I did five months ago. They certainly got me out of the horrible, deep suicidal depression that I used to have. Barely any side effects at 30mg, no brain zaps like the SSRI's, the best Anti-Depressant I've ever had.
Working out/exercising really really helps, particularly for stress due to the endorphin release. They are good for sleep but they're not as sedating in higher doses, but work as a stronger AD. Find yourself a goal, then when you reach it, find another and another. Also try and cut down on your alcohol use.
Nice to hear this kind of response.
I've been on a very low dose, 7.5mg basicly for chronic Insomnia as well as depression. Started 1.5 weeks ago and i already feel better, no side effects apart of some minor stuff and very weird nightmares. Basicly my sleeping pattern has been fixed since the first day i took it and it of course has a huge effect alone. Going to get the gym card too in the coming days. Lets see!
Thanks for sharing your experience. Everyone responds differently, so it's useful to know the variety of experiences that exist. It can be difficult to get people to stick with a drug when the benefits may only appear months in the future, but sometimes that is what happens.
Mertazazipine combined with Sativa Cannabis certainly does give you close eye visuals which are similar to a 75ug dose of LSD. I enjoyed the experience but that's because i like psychedelic experiences.
The trouble with mirtazapine ,( I have been on it for 5 years. Is trying to come off it ,serotonin syndrome is terrible. Sweating attacks, uncoordinatin vertigo ,paranoia and a general sense of unreality. I would only use it for short term. Or as a sleeping aid. Its the first port of call for drs to give out t o treat depression in the UK. Use with caution and not for long is my advise.
Hi! Can you do one on Cymbalta?? I wanted to be put on the antidepressant drug effexor but my psychiatrist swears up and down that Cymbalta is better...
I have been on Mirtazapine for oh man...MONTHS!! And it's been the only one and best one that has been working for me except I noticed well...it could be from other things but I will randomly "lash out and snap be easily irritated and annoyed." That doesn't happen normally with people who are on Mirtazapine right? Or does it? I have panic attacks and EXTREME anxiety/fear I am scared to leave the house most of the time so if anyone has been on Cymbalta will that help the anxiety part a lot too ?, I just hate the weight gain as well. I wanted to switch so bad and well just have to see. Please let me know - anyone - who has been on Cymbalta and what happened while you were taking it?? Thank you again!! :)
I take Mirtazapine, and an hour after I take it, i get very serious side effects. It causes Hallucinations, vision changes, drowsiness, dizziness, eye pain, color changes, auditory hallucinations, and more.
I have been taking these for a while brilliant for sleep at night and through the night, previously I would take ages to get to sleep and wake up early in the morning not getting much sleep at all these have worked well for me in that sense, however I have noticed recently when cutting down from 30 mg to 15mg I have been getting a bit panicky maybe once a day I have cut down for 2 weeks now and plan to come off them completely hopefully I can take control of my life again and start being me.
Somebody I care about started on this almost five years ago and started on 15mg each night for sleep. They sleep good on 15mg. But they were also being treated for depression and the dose was increased to 45mg. They could not sleep a wink. It seems the drug sedated in low dose but stimulated thinking at higher dose which is why the dopers are using higher doses. I myself tried 15mg after visiting my own doctor. It nearly killed me. I was responsible and had with food. But 30 mins later I had to leave a social setting to lay down in a dark room with severe dizziness, nausea and cold sweating while I gradually faded. It was absolutely terrifying. My advice from the experience? Go with the prescribed meds. Always do your own full research into any medication and understand what research is out there and what people have experienced. Know as much as you possibly can and never do recreational experiments. There have been too many accidents and time and again it affects others not just you. Thanks for you work Russell.
Very good video, like always! Wanted to ask, can you please also do a video on an other antidepressant called venlafaxine/Effexor? It has some very interesting pharmacology and it's chemical structure is practically identical to that of Tramadol. Would be an interesting video. ;)
I've been taking 45mg of this for a few years. A while ago i took some LSD and had one of the worst trips of my life, i took 45mg Mirtazapine 20/30 mins later the feeling of impending doom was starting to lift. It probably saved my life.
I have been prescribed this for only a few months, and wow this has been THE BEST anti depressant ever seriously....SSRIs omg I did HORRIBLE on it. Welbutrin made me go so crazy to end up in the hospital unfortunately :/ this was brought up and it actually seriously works and I have THE WORST anxiety social anxiety you name it...depression has been so much better for me... Hoping you all it works well for you too!! 😊
I LOVE mirtazapine. It helps me sleep like a baby, gives me insanely vivid dreams, and doesn't have any side effects for me anymore. It's odd, at the 15 mg dose I was more groggy during the day and hungry all of the time, but over the past year as I've moved up to 45 mg all of those properties disappeared. The only time I tried an SSRI (sertraline) it made me sick as a dog and ruined my life for about a month, so I'm very thankful that there are atypical antidepressants such as mirtazapine. I used to take trazodone for insomnia, but mirtazapine is much more sedating and soothing at bedtime. Trazodone always made me feel kinda like my heart was going to jump out of my chest, like I'd been hit by a tranquilizer dart and had no choice but to pass out, but it was in no way relaxing or anxiolytic. And the grogginess in the morning after trazodone (especially if you don't have a tolerance to it yet) is second to none. I know everybody reacts to drugs differently, but mirtazapine is so superior to trazodone in every way. It's definitely improved my quality of life.
MY QUESTION IS THIS, I AM PROSCRIBED TO TAKE MIRTAZAPINE AT BED TIME AND HALF A PILL OF OLANZAPINE AT BED TIME...IS THAT SAFE BECAUSE BOTH CAN KCOCK YOU OUT LIKE A PUNCH TO THE JAW BY FLOYD MAYWEATHER!?
I once knew a guy who had these prescribed to him. Once popped these while drinking, due to prescription as he should. He pretty much lost all control and memory for the next 30 minutes.
He lost all barriers that prevent you from doing stupid shit, it was pretty much what you would propably witness someone doing on MDMA. For example he kissed some random girl right infront of hes girlfriend.
Another guy tried one too and the results were pretty much the same. Its like 30-60 min long MDMA roll and no recollecrion ehat happened afterwards.
So i guess my advice is taking these while drinking alcohol isnt propably a good idea.
I've been prescribe Mirtazapine. Just start on it. The problems is I've been do some research and found out that Mirtazapine can cause serious high in cholesterol and triglycerides even on healthy person who consume it. It cause more anxiety and made me think to stop it before it geta worse. Please clarify this. Had to know this for sure from all of you guys that been used for long term and who knows about this med more detail. I do appreciate your comment guys.
It does work well for me. To bad the side-effects are too bad for me. I sleep way way way to much, and any anxiety reduction it gives me goes away when i drink the copious amounts of coffee that i need to make the brain-fog lift.
Thank you very much as I found this easy to understand and very informative regarding medical and recreational use
I would give your short video 5 stars from 5 because it was so helpful and answered few questions that I wanted answers to and I got that and more
I'm a naturally thin man, almost anorexic looking, always had trouble putting on weight. this drug combined with weight training and healthy eating I've been able to put a 30lbs and look much healthier. some side effect I noticed was frequent night time urination 4-7 times right before bed. and some drowsiness during the day, like a hangover without the sick feelings.
Can mirtazapin cause fatigue while drinking? Some weeks ago i drank like 7 glasses of little bit vodka with the combination of orange juice at a party. It’s what I normally drink without problems. But that night I fainted one time and was out for 2-3 minutes and was perfectly fine for another 2 hours. Then I fainted again and vomited everywhere. I was fine after a few minutes but I choose to go home, but nothing happend after that. I thinks it’s weird and i don’t know if it was the mirtazapin or that i might been drugged?
I sold 30 mg of these to a kid in school along with 2 mg of xanax and well we both were fucked. The dude was so fucked his mouth was wide open with hiccups and spit was coming out of his mouth. He couldnt walk and even bumped his fucking head on the wall. He later passed out in class. I had a fucking axiety attack dat day as i was scared that he gonn die or gonna get caught but miraculously niether happened. Scariest day of my life!
Beware when taking this medicine! I warn you people! It caused me to have sexual dysfunction, hypogonadism. It also led me to having panhypopituitarism, meaning your hormones will be at extremely low levels. It raised my prolactin levels leading to hyperprolactinemia. This is bad for males because again it leads to lowering hormones like sex hormones, in addition to your testosterone and thyroid. It led to me getting an macroadenoma, a tumor of the pituitary. It also works in the region of the hypothalamus, Supra charismatic nucleus, affecting your hunger, sleep, thirst. I can not sleep without taking melatonin supplements now. Doctors are baffled at how this happened. I have been now seen at the NIH and John Hopkins for research and treatment. I warn you folks do not take these psych meds without doing research!
I've only been prescribed this for 30 days and the pharmacy said it might take a couple weeks to work. The 15 mg was prescribed. I have 6 left and it slightly helps my insomnia, but I still have many nights with continued insomnia, BUT the big downside is that I have gained about 8 pounds since I began this medication. So....... I may have to stick with continued insomnia or buy a new wardrobe. A lose- lose situation with no answer for my insomnia? Temazepan did nothing either. Craving ZZZzzzzzzzz
Once you take it a while, it's very hard to discontinue. You feel like you will never sleep again and it's makes you very irritable, typical SSRI discontinuation symtoms. It does nothing in conjunction with cannabis in my experience.
Why the fuck do I have to go to a doctor every 6 months just to tell them I still have depression (no shit sherlock) so they can write a new script? I work a full time job, I don't have time for this bullshit. Fuck this drug, it's a fucking placebo. I don't need this stupid drug.
From what I've been told, from 10 to 30 mg is the sedation range. My sweet spot is around 15 to 20 mg. If you pass above 30 the sedation actually gets less. Thats good for anti depressant but not as a off label sleep medication.
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.