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Pharmacology - ANTIPSYCHOTICS (MADE EASY)

Оценок: 1496 | Просмотров: 72040
Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered include: schizophrenia, role of dopamine in the development of psychosis, dopamine pathways in the brain (Mesolimbic, Mesocortical, Nigrostriatal, Tuberoinfundibular), positive & negative symptoms of schizophrenia, dopamine & serotonin receptors, mechanism of action and side effects of antipsychotic drugs (1st generation typical & 2nd generation atypical). Drugs mentioned include; Haloperidol, Fluphenazine, Prochlorperazine, Trifluoperazine, Chlorpromazine, Aripiprazole, Clozapine, Lurasidone, Olanzapine, Quetiapine, Risperidone, and Ziprasidone.
Категория: Образование
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Текстовые комментарии (79)
Rakesh ranjan (2 часа назад)
Awesome lectures..plz make more videos..lots of love
digxx (2 часа назад)
What I find interesting about the newer class of (so called atypical) neuroleptics is their loose binding to D-receptors in contrast to the old typical ones. In exchange they have a very high affinity to 5HT (Serotonin) and guess where the body has the most of these receptors which are then antagonized? In the gut! So basically you loose your gut feeling...
dhuha khydheir (4 дня назад)
شلون اشترك بالقناه مجاي يصير اشتراك
Daniel Malone (6 дней назад)
Good video. Except, it is stated and implied from the neuronal diagram of serotonergic neurons synapsing with dopaminergic neurons that 5-HT binds to 5-HT2A receptors on dopaminergic neurons to decrease dopamine release. And that antagonism of these 5-HT2A receptors results in an increase in dopamine release. The problem with this theory is that 5-HT2A receptors are coupled to Gq/11 proteins, that when activated, stimulates phospholipase C activity, thus enhancing intracellular Ca2+ levels. This is a trigger for vesicular release of neurotransmitter. My question for you is, how do you explain activation of a Gq/11 coupled 5-HT2A receptors produces a decrease in dopamine release?
Judi Blakely (11 дней назад)
appreciate you stringing the neurotransmitters, pathways, and side effects. Very helpful! Thanks!
Ali Emre Öztürk (24 дня назад)
Great video, thanks a lot
Daniel Malone (26 дней назад)
Good video. Except, it is stated and implied from the neuronal diagram of serotonergic neurons synapsing with dopaminergic neurons that 5-HT binds to 5-HT2A receptors on dopaminergic neurons to decrease dopamine release. And that antagonism of these 5-HT2A receptors results in an increase in dopamine release. The problem with this theory is that 5-HT2A receptors are coupled to Gq/11 proteins, that when activated, stimulates phospholipase C activity, thus enhancing intracellular Ca2+ levels. This is a trigger for vesicular release of neurotransmitter. My question for you is, how do you explain activation of a Gq/11 coupled 5-HT2A receptors produces a decrease in dopamine release?
Steve Stevens (29 дней назад)
There is one thing that in my opinion these anti-psychotics all have in common – they don’t work
Hassan (1 месяц назад)
If mental problems arise because of lack of dopamine why is the treatment dopamine blockers when that will cause greater dysfunction. No wonder these antipsychotic dopamine blockers are so ineffective and dangerous wrg to side effects. I don't know who's idea this was but it was a terrible one. Give these patients supplements of essential amino acids to kickstart the body to regulating itself. The body isn't fickle.
Yvonne Tuszing (1 месяц назад)
Thank you so much for this video!
Dr Ferdous (1 месяц назад)
Please,sir, upload a video about antiparkinsonian drugs
Nayelhi Sanchez (1 месяц назад)
Thank you! This video was very helpful.
Fathima Najla (1 месяц назад)
Thank you
Becca Mardis (1 месяц назад)
Your videos are legendary. Such an underrated channel. I watch your content for fun!
Assasson Worrior (1 месяц назад)
I put on my PS4 Pro unable to play for more than 10 mins when I could spend 4 hours non stop.
Assasson Worrior (1 месяц назад)
Also loosing competitive edge on games like Cod
Assasson Worrior (1 месяц назад)
Not to mention the strange behaviours of loosing the ability to understand text that you just read like not being able to read larger texts when you could do this naturally before.
Assasson Worrior (1 месяц назад)
I hope they develop better treatments by funding research into this field because many people in UK have this,
Assasson Worrior (1 месяц назад)
My experience: Having taken these, there is no way back. You have to have these for a life time and they have severe side effects like muscle stiffness from walking, feeling hungrier than usual and gaining weight. There is also a blurred vision and headaches issue.
Assasson Worrior (1 месяц назад)
It feels so natural making it difficult to identify your behavioural mood swings.
Jerry (1 месяц назад)
I love you man. This is how one man helps another😘😁
Assem Abuelkhair (1 месяц назад)
Thanks a lot! Videos are awesome with a great and easy illustration Thanks again :)
Dr. Battula Pradeep (2 месяца назад)
Sir please do video on Anti-cancer drugs
nouf Ymm (2 месяца назад)
This help me in preparation of my pharmacology assignment, a lot of love & thanks 💙🌨
KrsFPV (2 месяца назад)
You might want to add in your assignment how bad these drugs are to the brain long term. I suffer every day because of these awful drugs and these doctors that I put my trust in as a kid have totally fucked it up!!!!
Thomas Lau (2 месяца назад)
A lot of side effects.
Moath Abdulghani (2 месяца назад)
Good shit
Ratna Stephenson Basimalla (2 месяца назад)
Thank you very much ❤️
Thomas Hughes (3 месяца назад)
Sychiatry is Pseudo Pscience. HARM is the middle word in PsychopHARMacology. These are torture drugs of permanent harm. There are no therapeutic effects or any side effects; only toxicity spectra. Psychiatry is a criminal enterprise that has deceived and silenced government by it's craft. Psychiatry is not science. Psychiatry is not medicine. Psychiatry is an activity of fortune seeking soldiers and greedy witches. One who first sets mind or hand to the practice of Psychiatry has abandoned the value of "Do No Harm".
pool star (27 дней назад)
They need to watch the negative feedbacks for antipsychotics its fckin hell, and i'm one of the victim of this poisonous drug
Hassan (1 месяц назад)
Amen brother keep preaching. The haters want to sear their consciences so they don't have to be affected by the evil they are committing. They will be the ones soon to be on these meds in an act of getting a taste of their own medicine.
Ben Black (2 месяца назад)
Stop freaking out and go back to trying to crack the case on 3 minute oats.
al masum (3 месяца назад)
This is the place where a doctor can feel proud...
Schizo &Human (3 месяца назад)
Love this-you made it very easy to understand what it’s doing to my brain 🧠
QuickSilverCS (3 месяца назад)
You sucks at this
denitze lara (3 месяца назад)
awesome video! thank you
Okeyza (3 месяца назад)
Thank you very much. You are awesome!
arvind (3 месяца назад)
thank you
Chi Lê Kim (3 месяца назад)
please Make a lesson about cortecosteroid . thanks
UOB Vines (4 месяца назад)
ThankyOu Sir
KYM (4 месяца назад)
Thank you for your clear explanation! 😊
Kayla Añasco (4 месяца назад)
Sir, I thought Atypical Antipsychotics blocks D4 receptor and 5-hydroxytryptamine. So what's the difference between D2 and D4 receptor?
Kayla Añasco (3 месяца назад)
+Speed Pharmacology Thank you sir. Now I understand the difference between the two.
Speed Pharmacology (3 месяца назад)
"The higher affinity of clozapine for D4 than for D2 receptors led to the speculation that the superior clinical profile of this drug was due to D4 receptor blockade (Van Tol et al. 1991). However, several typical antipsychotic drugs, including haloperidol, have similar affinity for D2 and D4 receptors (Roth et al. 1995), whereas several atypical drugs, including quetiapine and amisulpride, have very low D4 affinity, suggesting that D4 affinity per se does not confer therapeutic efficacy or low EPS liability. Moreover, several clinical trials with D4 selective antagonists failed to show antipsychotic efficacy (Bristow et al. 1997; Corrigan et al. 2004; Kramer et al. 1997)" Source: "Current Antipsychotics" by Gerhard Gross & Mark A. Geyer eds., 2012 page 35-36.
J. J (4 месяца назад)
Plz upload a video on Cardiac heart failure drugs
Dr Sweta Ruparel (4 месяца назад)
Thanks a lot for wonderful summary !!! 👍
arvind (4 месяца назад)
Nobody thought me so simply. Thank u very much
KHADIJA MALIK (4 месяца назад)
Plz upload video about respiratory drugs
david yang (4 месяца назад)
Ugh the explanation is so shallow and doesn't help :( Wish there was a review for graduate level, not for basic college
Δάφνη Κόλλια (4 месяца назад)
wish i found your videos sooner!! please make a video about antiepileptics or drugs for parkinson's disease :)
Chaitanya Bhujbal (4 месяца назад)
Thank you thank you thank you 😊
Essko Raim (5 месяцев назад)
i dont think so people are enjoying pharm-videos, but ur job was rly helpful ty!
Tony Montana (5 месяцев назад)
I take risperidone injection 25mg every two weeks
Tony Montana (4 месяца назад)
Hmm, I don’t know about abilfy but u can tell your doctor that he might tell your son to take it twice a day or just ask for the injection abilfy that might work
el Terre (4 месяца назад)
+Tony Montana he take abilify
el Terre (4 месяца назад)
+Tony Montana ok my son is taking 7.5 hes good but looks like it starts wearing off in the evening time
Tony Montana (4 месяца назад)
Better but i need more time to know .. but for now my OCD and anger is way better .. side effects is that you sleep a lot but i can live with that
el Terre (4 месяца назад)
How are u doing bro?
Remanence Nguyen (5 месяцев назад)
Is there more dopamine in the mesocortical pathway which is why there is less negative symptoms when taking Atypical antipsychotics? And theres less risk of Extra Pyramidial Side Effects because of more Dopamine in the striatial pathway? Can someone clarify my brains fried.
Half Tomato (4 месяца назад)
Atypicals block seratonin receptors causing Dopamine to increase. And this Dopamine attaches to D2 receptor but removed quickly. Attaches and go! And this might give the similar function of normal level of dopamine. Dopamine is more but action is less!
Malek Bitar (4 месяца назад)
Blockade of serotonin receptors will increase dopamine levels in desirable area. Thus, less Extra Pyramidial side effects.
Di Lou (4 месяца назад)
Is there more dopamine in the mesocortical pathway which is why there is less negative symptoms when taking Atypical antipsychotics? I guess there is something to do with antagonist effects on 5HT2A receptor. There is less risk of Extra Pyramidal Side Effects because of more Dopamine in the striatial pathway? Atypical antipsychotics has less suppression effects on migrostriatal pathway due to less affinity on dopamine receptor. (That's my understanding, not 100% sure it's accurate)
Mental Health with Dr Elliott (5 месяцев назад)
Nice video. I like the fact that you went into specific dopamine receptor selectivity and the different dopaminergic pathways that can be implicated. Subscribed to your channel. :)
Amanpreet Kaur (5 месяцев назад)
Excellent presentation
H (5 месяцев назад)
Thanks alot. Hello from Iraq.
frankanator (5 месяцев назад)
what am i doing here on my summer break lol TT_TT
Eric Alex Anderson (3 месяца назад)
"Wake me up when September ends?" haha not super atypical don't worry :3
RockyCycle (5 месяцев назад)
I *want* to be able to thank you and say how much I appreciate this video... but really I'm just pissed off you're this late.
Pi thagoras (5 месяцев назад)
How doe you differentiate between positive and negative phychotic symptoms that you speak of?
Mental Health with Dr Elliott (5 месяцев назад)
Negative symptoms are incredibly hard to treat and can often appear similar to extra-pyrimidal side effects from first generation antipsychotics (usually in people taking these via depots) or from sedation on olanzapine or clozapine. Amisulpride is a 2nd generation with (I believe) some loose evidence for improving negative symptoms but it's still a tricky one.
Speed Pharmacology (5 месяцев назад)
Positive symptoms refer to an excess or distortion of normal functions (hallucinations and delusions). Negative symptoms refer to a decrease or absence of normal behavior (lack of motivation, restrictions in emotional and verbal expressiveness, social disengagement)
Kuldeep Singh (5 месяцев назад)
Can't thanks u enough always eagerly waiting for your vedeos sir.. This one was masterpiece!!
nikostsa1324 (5 месяцев назад)
I just wanna thank you! You sir helped me a lot!!! New subscriber
Ahmad Althabteh (5 месяцев назад)
perfect timing....i dont usually subscribe to channels, but when i do, its speed pharmacology ...keep it up.. thank you for your work....youre a beast
waseem khan (5 месяцев назад)
I was waiting for this master piece 😍
ØMÑÁ T. (5 месяцев назад)
Your videos are always so great and give a great overview... Giving all the relevant information tht we need to know... If u could.. please please please make a video on anti epileptic drugs... Thank you!!😊
sultan kareem (5 месяцев назад)
Thanks alot for your smart illustration
Kevin Yee (5 месяцев назад)
Thank you - love this review
Ebrahim Alqadasi (5 месяцев назад)
Great as always 👍 .. Thank you for your efforts

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