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Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered include: schizophrenia, role of dopamine in the development of psychosis, dopamine pathways in the brain (Mesolimbic, Mesocortical, Nigrostriatal, Tuberoinfundibular), positive & negative symptoms of schizophrenia, dopamine & serotonin receptors, mechanism of action and side effects of antipsychotic drugs (1st generation typical & 2nd generation atypical). Drugs mentioned include; Haloperidol, Fluphenazine, Prochlorperazine, Trifluoperazine, Chlorpromazine, Aripiprazole, Clozapine, Lurasidone, Olanzapine, Quetiapine, Risperidone, and Ziprasidone.
Категория: Образование
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Текстовые комментарии (48)
Thomas Hughes (12 дней назад)
Sychiatry is Pseudo Pscience. HARM is the middle word in PsychopHARMacology. These are torture drugs of permanent harm. There are no therapeutic effects or any side effects; only toxicity spectra. Psychiatry is a criminal enterprise that has deceived and silenced government by it's craft. Psychiatry is not science. Psychiatry is not medicine. Psychiatry is an activity of fortune seeking soldiers and greedy witches. One who first sets mind or hand to the practice of Psychiatry has abandoned the value of "Do No Harm".
al masum (14 дней назад)
This is the place where a doctor can feel proud...
Tania Martinez (15 дней назад)
Love this-you made it very easy to understand what it’s doing to my brain 🧠
QuickSilverCS (18 дней назад)
You sucks at this
denitze lara (21 день назад)
awesome video! thank you
Okeyza (24 дня назад)
Thank you very much. You are awesome!
arvind (25 дней назад)
thank you
Chi Lê Kim (27 дней назад)
please Make a lesson about cortecosteroid . thanks
UOB Vines (1 месяц назад)
ThankyOu Sir
카라 (1 месяц назад)
Thank you for your clear explanation! 😊
Kayla Añasco (1 месяц назад)
Sir, I thought Atypical Antipsychotics blocks D4 receptor and 5-hydroxytryptamine. So what's the difference between D2 and D4 receptor?
Kayla Añasco (28 дней назад)
+Speed Pharmacology Thank you sir. Now I understand the difference between the two.
Speed Pharmacology (29 дней назад)
"The higher affinity of clozapine for D4 than for D2 receptors led to the speculation that the superior clinical profile of this drug was due to D4 receptor blockade (Van Tol et al. 1991). However, several typical antipsychotic drugs, including haloperidol, have similar affinity for D2 and D4 receptors (Roth et al. 1995), whereas several atypical drugs, including quetiapine and amisulpride, have very low D4 affinity, suggesting that D4 affinity per se does not confer therapeutic efficacy or low EPS liability. Moreover, several clinical trials with D4 selective antagonists failed to show antipsychotic efficacy (Bristow et al. 1997; Corrigan et al. 2004; Kramer et al. 1997)" Source: "Current Antipsychotics" by Gerhard Gross & Mark A. Geyer eds., 2012 page 35-36.
J. J (1 месяц назад)
Plz upload a video on Cardiac heart failure drugs
Dr Sweta Ruparel (1 месяц назад)
Thanks a lot for wonderful summary !!! 👍
arvind (1 месяц назад)
Nobody thought me so simply. Thank u very much
KHADIJA MALIK (1 месяц назад)
Plz upload video about respiratory drugs
david yang (1 месяц назад)
Ugh the explanation is so shallow and doesn't help :( Wish there was a review for graduate level, not for basic college
Δάφνη Κόλλια (1 месяц назад)
wish i found your videos sooner!! please make a video about antiepileptics or drugs for parkinson's disease :)
Chaitanya Bhujbal (2 месяца назад)
Thank you thank you thank you 😊
Essko Raim (2 месяца назад)
i dont think so people are enjoying pharm-videos, but ur job was rly helpful ty!
Tony Montana (2 месяца назад)
I take risperidone injection 25mg every two weeks
Tony Montana (1 месяц назад)
Hmm, I don’t know about abilfy but u can tell your doctor that he might tell your son to take it twice a day or just ask for the injection abilfy that might work
el Terre (1 месяц назад)
+Tony Montana he take abilify
el Terre (1 месяц назад)
+Tony Montana ok my son is taking 7.5 hes good but looks like it starts wearing off in the evening time
Tony Montana (1 месяц назад)
Better but i need more time to know .. but for now my OCD and anger is way better .. side effects is that you sleep a lot but i can live with that
el Terre (1 месяц назад)
How are u doing bro?
Remanence Nguyen (2 месяца назад)
Is there more dopamine in the mesocortical pathway which is why there is less negative symptoms when taking Atypical antipsychotics? And theres less risk of Extra Pyramidial Side Effects because of more Dopamine in the striatial pathway? Can someone clarify my brains fried.
Half Tomato (1 месяц назад)
Atypicals block seratonin receptors causing Dopamine to increase. And this Dopamine attaches to D2 receptor but removed quickly. Attaches and go! And this might give the similar function of normal level of dopamine. Dopamine is more but action is less!
Malek Bitar (1 месяц назад)
Blockade of serotonin receptors will increase dopamine levels in desirable area. Thus, less Extra Pyramidial side effects.
Di Lou (1 месяц назад)
Is there more dopamine in the mesocortical pathway which is why there is less negative symptoms when taking Atypical antipsychotics? I guess there is something to do with antagonist effects on 5HT2A receptor. There is less risk of Extra Pyramidal Side Effects because of more Dopamine in the striatial pathway? Atypical antipsychotics has less suppression effects on migrostriatal pathway due to less affinity on dopamine receptor. (That's my understanding, not 100% sure it's accurate)
Mental Health with Dr Elliott (2 месяца назад)
Nice video. I like the fact that you went into specific dopamine receptor selectivity and the different dopaminergic pathways that can be implicated. Subscribed to your channel. :)
Amanpreet Kaur (2 месяца назад)
Excellent presentation
Hermes (3 месяца назад)
Thanks alot. Hello from Iraq.
frankanator (3 месяца назад)
what am i doing here on my summer break lol TT_TT
Eric Alex Anderson (23 дня назад)
"Wake me up when September ends?" haha not super atypical don't worry :3
RockyCycle (3 месяца назад)
I *want* to be able to thank you and say how much I appreciate this video... but really I'm just pissed off you're this late.
Pi thagoras (3 месяца назад)
How doe you differentiate between positive and negative phychotic symptoms that you speak of?
Mental Health with Dr Elliott (2 месяца назад)
Negative symptoms are incredibly hard to treat and can often appear similar to extra-pyrimidal side effects from first generation antipsychotics (usually in people taking these via depots) or from sedation on olanzapine or clozapine. Amisulpride is a 2nd generation with (I believe) some loose evidence for improving negative symptoms but it's still a tricky one.
Speed Pharmacology (3 месяца назад)
Positive symptoms refer to an excess or distortion of normal functions (hallucinations and delusions). Negative symptoms refer to a decrease or absence of normal behavior (lack of motivation, restrictions in emotional and verbal expressiveness, social disengagement)
Kuldeep Singh (3 месяца назад)
Can't thanks u enough always eagerly waiting for your vedeos sir.. This one was masterpiece!!
nikostsa1324 (3 месяца назад)
I just wanna thank you! You sir helped me a lot!!! New subscriber
Ahmad Althabteh (3 месяца назад)
perfect timing....i dont usually subscribe to channels, but when i do, its speed pharmacology ...keep it up.. thank you for your work....youre a beast
waseem khan (3 месяца назад)
I was waiting for this master piece 😍
ØMÑÁ T. (3 месяца назад)
Your videos are always so great and give a great overview... Giving all the relevant information tht we need to know... If u could.. please please please make a video on anti epileptic drugs... Thank you!!😊
sultan kareem (3 месяца назад)
Thanks alot for your smart illustration
Kevin Yee (3 месяца назад)
Thank you - love this review
Ebrahim Alqadasi (3 месяца назад)
Great as always 👍 .. Thank you for your efforts

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