Mental health is incredibly complex, due in no small part to the complicated interactions of chemicals and neuroreceptors in our brains. Here are four common misconceptions about antidepressants, and what the science behind them actually shows.
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Slight misconception at 3:50 - 95% of your serotonin doesn't GO to your gut. 95% of your serotonin is PRODUCED by your gut. And that includes the amount that is made by your gut bacteria. And that's why you cannot treat depression without paying attention to what you eat (and your exercise and sleep) - treating it only via medication is like using a monkey wrench to fix your watch.
LYING BASTARDS !!! PSYCHOTROPIC MEDICATION WILL GET YOU HIGH. OF COURSE YOU FEEL BETTER. UNFORTUNATELY YOU DON'T FEEL BETTER CONCERNING THE REASONS YOU STARTED TAKING THE MEDICATIONS IN THE FIRST PLACE, YOU FORGET WHEN HIGHED. DOCTORS DO NOT TEST YOUR SEROTONIN LEVELS BEFORE YOU GET MEDICATION , IT'S A GUESS BY PSEUDO SCIENCE !!!
My psychiatrist did the GeneSight genetic test on me to find out which antidepressants may be more effective than others. When we got the results back, it turns out that all the antidepressants that I had been on didn’t work, because I have a gene that makes me an ultra rapid metabolizer. The results came with a list of drugs that I metabolize too quickly and ones that could work better for me. So now I’m trying a medication on the list that may work better. Hopefully it’s more successful than the previous meds. I recommend this genetic testing. Make sure your insurance covers it. Mine did, but not all insurance covers it.
So that meta study apparently wasn't a good tool to look at the efficacy of Antidepressants (at least for "non-severe" cases). What kind of meta-analysis would've been a better fit for evaluating Antidepessants then?
I'm asking, because "personalized dosages + trial&error + time" sounds a little like something that is used to defend homeopathy.
Of course it has other issues like plausibility. But just looking at effects, how would a proper meta-study look like?
single studies probably go something like this:
- group A: gets the drug
- group B: gets the placebo
(- group C: non intervention group)
- both groups try to find the right dosage over a long term period
And meta-studies would then have to group by "was personalized" instead of dosage?
P.s.: please do not read this as me trying to disapprove Antidepressants!
People talk about med-shaming, but not often the reverse, when people choose not to (or cant for complext medical reasons) take medication. It doesn't mean that their depression "isn't bad enough" or whatever
I second the point that all antidepressants do NOT work the same way. I tried two that both ended up just pushing me into that perilous gap between lucidity and comfortable numbness, and very nearly hurt myself because of that. But then I switched to the one I take now and haven't had those thoughts since. It really is important to find the right one.
Antidepressants get you high. They don’t at all, they stabilize your mood
People who take the wrong type of antidepressant can even have their symptoms worsen (that’s what happened to me)
There is a huge misconception that depression can be "cured" by lifestyle choices and positive mental attitude. The truth is, some depression is a result of your lifestyle, but most people I know including myself have a actual chemical imbalance in our brains. Its something we live with every day, and its not something that can just go away.
one "misconception" in Denmark is that antidepressant are called happiness-pills in the press and by some people. The name gives the wrong idea about the medication, while it does make you more happy, the name make it seem like it makes you happier than others, and it is a way to happiness, instead of it being a way for you to live a normal life, while you work on whatever got you into depression in the first place
It helps more to understand that "antidepressants" don't actually exist. There is no medication which can treat depression directly and none of the mentioned types of medications work right if you're malnourished. A large proportion of depression is diet, health and environmental factors such as toxins, poisons and noise.
Trying to compensate for malnutrition, environmental aggravation, poor health, poisonous air and illness with a pill that changes your serotonin levels is like trying to put out a fire by encouraging it to leave combustible material alone and take "the higher path".
Its been proven that mental health is affected more by nutrition, sleep, exercise and air quality than any other factors. Fix those four IN THAT ORDER and then seek help from a doctor. You have to lay the bricks right to build a house.
I literally went and checked which type is the one I'm taking. It's SSRI paroxetin.
You should also mention withdrawal when you stop taking the pills if we're talking about the time to have any effect.
They take a week or two to start working, but sure as hell don't wait that long for the withdrawal symptoms to appear. Usually two or three days and it's not fun.
The best most effective antidepressants are diet and exercise. They work within days and the side effects are better health.
A diet devoid of carbohydrates especially sugar and polyunsaturated oils.
Sugar causes inflammation and upsets brain chemistry Polyunsaturated oils cause oxidation inflammation and cell damage and heart attacks and cancer.
Through my journey with Bipolar Disorder, ADHD, and Sensory Processing Disorder, my doctors and I have discovered that I can actually retain serotonin really well, but, I needed help with synthesizing and removing serotonin, as evidenced by the fact that I got a life-threatening case of serotonin toxicity from the minimum doses of Zoloft and Tramadol. On the other hand, I metabolize dopamine exceptionally fast, as evidenced by the fact that narcotic painkillers don't work very well for me, as they work on dopamine. I take lithium carbonate, which helps me utilize serotonin and dopamine, in addition to methylphenidate, which helps me make dopamine and adrenaline to give me energy to combat the depressive side of things.
You see, depression isn't just about serotonin, but your ability to make and utilize neurotransmitters as a whole. Serotonin is only one tiny piece of the equation.
I've been clinically depressed since I was 9 and did my 1st attempt of suicice. Ever since then, my family has spent countless amounts of cash and insurance on medications. Up to maximum dose and none have proven effective after a 3 month period. It tends to make things even worse and I become more isolated and depressed. I have no idea what to do at this point
What about the fact that taking an antidepressant can have permanent changes to your brain? Or how your brain will try to adjust to the medication? How an ssri is usually prescribed first to teenagers..and they stop the absorption of serotonin..leading the brain to slow the serotonin intake, because it’s not absorbing. Or how if you don’t teach yourself to be happy the synapse won’t retain it well..like when you take a test. If you don’t study you’ll forget it the next day. If you believe something is going to cure you, it will..like placebos..because it’s retained. So even if a pill isn’t a sugar pill, if you believe it will work it will. Too much serotonin being made and not absorbed can cause that feeling of numbness or major mood swings.
Can we just take a minute to recognize that the theory behind traditional antidepressants is based on false logic. The reason that we even try to increase serotonin is because when scientists were looking at reserpine they observed that it seemed to make the mice depressed. The scientists also noticed that reserpine decreased serotonin levels ... So the faulty assumption was made low serotonin must cause depression. This is only a bit of the story however, don't simply believe things are true because some "professional" has told you so.
Ask questions because that is how we learn.
This video goes into it in more detail.
+Baruch Ben-David ... But so do placebos. I'm not saying some people don't get results but that we should really approach this problem with an open mind. For example looking into other theories as to why people are depressed. Consider bndf (or brain derived neurotrophic factor) and how it is often low in individuals who are depressed. When we look at something like noopept, that has been shown to increase bdnf, it has been found to have antidepressant qualities.
Furthermore, a brand new antidepressant being developed, called esketamine, has recieved breakthrough status twice and is now in the third stage of clinical testing. Ketamine itself has been shown to be a more effective treatment for depression than several ssri's.
I'm speaking from experience as well, i was on many different antidepressants both ssri's and other kinds. Instead of really helping it seemed to ameliorate certain symptoms instead of treating the problem. Which brings me back to my initial argument, we need to look at things from a scientific perspective not just assume how the brain works based on faulty logic. If we can determine scientifically what the root cause of the problem is then we can treat the problem and actually fix the issue. Most of the time in medicine, specifically mental health, the focus is on treating the symptoms as they come along rather than treating the root. This is the equivalent of seeing a dislocated joint and taking pain medication instead of fixing the joint. It just doesn't make sense.
All i was trying to point out is that for around 50 years we've been trying to fix a problem in a very unscientific way. For a society that is so advanced this should not be the case.
From the time I was 20 to the time I was 60, I was "depressive." Sometimes it was suicidal and sometimes it was just an inability to work or create. I went though the :poke and hope" method of prescribing mess that might work an, of course, most of them didn't. Mysteriously, at some point, I out grew it. I involved myself in community development and arts projects. I got married. My life changed. No. I'm not a perfect being or husband or citizen but..I am going to be productive, change thins in the
City w=here I live and make my partner content.
Purely anecdotal: but as regards the notion that the anti-depressants make some changes in how your brain processes thoughts...I think that seems accurate from my own experience. I've had depression for what seems like my entire life; I still require therapy as well as medication, though due to the sheer awfulness that is US health care right now I'm forced to do without the therapy (and struggling to keep the medication too but I digress). However I did notice - after a time (more than six weeks, something more like six months) that I was having less trouble with certain kinds of problem thinking - I'm prone to getting stuck in that awful downward spiral, the one that can often turn into a full blown anxiety attack or put me in my bed for hours unable to do anything but weep. Well, that stopped happening. The spiral would start, but I got more and more successful in derailing the whole thing before it got worse.
No it's not a miracle medicine - there isn't one, for anybody's illnesses. But I fought against medication for years and years, thinking as so many seem to do that taking the medicine was admitting defeat in some way, or was going to force me to be some zombie version of myself, numb to the point of not being able to respond to *anything.*
I would wish that every single school would show this series or at LEAST this video and others relating to depression and anxiety to their classes. Children need to know better than the grownups. Teaching them early how to recognize the signs, and how to handle the subject kindly, and how to treat their friends who struggle with these troubles...I can't even imagine how many tragedies might be prevented by simply spreading that knowledge so that kids aren't hurting each other to death *on accident.*
i've been on antidepressants for nearly half my life, since i was 11. i've tried over a dozen different kinds and i've never had any relief from my mental illnesses. i wish i wasn't taking them now, but the withdrawal symptoms are so severe, panic attacks and crying all day and this intense twinge in my chest, which didnt go away until i gave up and took my meds again 4 or so days in. i have no idea what it feels like to be medication free, and every time i go to the doctor and am honest and say that i still have bad depression and anxiety, they try to up the dose of the one I'm on, which even a 50% increase (minimum avaliable) to my current dose makes me throw up a lot and unable to work or function. ugh. weed works better than anything but i have to hide it from everyone, my family, my doctors, employer of course, and it's totally out of pocket and sometimes hard to afford.
+RedHeart64 RedHeart64 thanks for the genuine effort in your reply... the hard thing about my current medicine is it's still under patent and only avaliable as extended release, with a coating that makes splitting them mess with the extened release effect. they recently introduced a dose that's half what mine is and while even this would be hard, next time i go to the doctor i might talk about tapering down... i just worry they won't take me seriously and say to just be more consistent about taking my meds when i explain that the withdrawal from them is the reason i want to stop taking them. especially since i'm still suffering, i feel like they're going to push for me to stay medicated, on my current antidepressant or something else. unless there's an antidepressant that won't send me spiralling downward after a couple missed doses, i don't know if i want to be on them at all.
I can relate. I was chemically dependent on a "new" medicine prescribed for a neurological condition years ago... although at the time they didn't think you could become dependent on the drug (now they know better). It did what it was supposed to (probably saved my life), but, well, it took me over a year to stop taking the meds and a couple of years before I stopped hurting - but the way I did it made getting off a lot slower, but kept the pain within reason (I could ignore it when I was busy).
I came off of the medicine by reducing the dosage little by little, over a period of a little over a year. I tried to go too fast a couple of times, and had the horrid results (uncontrollable convulsions while you're conscious is NOT fun), and had to backtrack (increase the dosage a tiny bit for a few days beyond the reduction I'd tried)... but it could be done. I understand there are meds now available that can help with withdrawal symptoms. Maybe something like that would work for your meds.
It sounds like you've gotten a big dose of 'Not Listening', a real problem for American medicine. (I got lucky and found a doctor who LISTENED.)
Good luck, and I hope you find something that works!
I've read that phrama companies that produce selective serotonin uptake inhibitors like Prozac work very hard to hide the fact that they don't work any better than a placebo. I'd rather be depressed than risk taking SSRI's that can induce all the symptoms they are supposed to treat, like suicidal thoughts, anxiety and lethargy.
I have tried several antidepressants. None of them have done anything helpful. But my depression is caused by physical issues with my brain (I have multiple sclerosis). The only chemical that has had any positive effect is caffeine. Again I have tried several antidepressants and mood stabilizers but they have all caused the same things, complete apathy and a lack of ability to think for myself. I would just do whatever was suggested to me because I didn't care whether I did it or not.
Antidepressants never worked for me, some of them even made me psychotic and suicidal. I'm very glad that I'm off them. I'm also glad if they help other people though. They are just not for everyone, it's a bit of a lottery.
I use to think my antidepressants weren't working. I had been taking them for about 3 months and I didn't feel different so I didn't know if they were working or not. Until I asked my best friend if she's noticed changes about me and she said oh yea the medication is working becuz when certain situations would pop up instead of getting really anxious, nervous or spiralling in thinking worse case, I would be fine. So she helped me see that it is working.
You have to balance the potential benefits against the possible harm. Drugs are not a perfect solution. Often they are only better than doing without. Sometimes they turn life from being impossible, to just bring difficult. Not ideal, but better than nothing.
I have been on just about every kind of med for depression that is out there and for me, they didn't work. In fact they had the exact dangerous opposite. Now I realize and agree that everyone responds differently to any medication but I also feel that this video is very one sided, very "pro medication". Instead I would have appreciated these myths to be presented with the understanding that some people do not take medication because they genuinely do not work instead of brushing it off as "you haven't tried hard enough" or "you just haven't found the right one" Medication isn't the only way to treat depression and other mental health issues, if they work for you then great and congrats but don't make the ones who can't or don't take them feel like they are doing something wrong. At the end of the day no one knows your body better than you, so don't be afraid to speak up and say "this isn't working" and find a doctor who will support what is best for you.
You didn't mention the sexual side effects. Also like Shanna Mae Slight said, its not an easy fix. My psychiatrist told me that anti depressants aren't nearly as effective on their own as they are combined with exercise. the same goes for exercise on its own. Also finding purpose in your life seems like it should be obvious but many people live without feeling like they have one.
The biggest miss information is that the manufactures know how these drugs work. Truth is they don’t, so the b.s about how they work is just that. Now if you read the information given with Prozac they say presumably it works this way. Or mechanism unknown. Now if it works for you let it work but they destroyed me. So be super careful and know if you haven’t found the root cause it’s just a band aid. It’s important to know that there are known reasons for depression anxiety, etc. if you have not been tested for any of these other causes. Taking these drugs may just make you worse. After all if the manufacture doesn’t know what they do neither does the doctor. At that point you might as well head off to Vegas you have a better chance of winning there.
It took years of "tinkering" for me to get put on the right combination of meds. I tried every med and experienced every side effect under the sun, and for a long time I didn't think I could come out of the dark headspace I was in. But, if it weren't for Buproprion, Lithium, and Lamotrigine, I would never have gone to college, owned a dog, or seen my little sister grow up. I would never have experienced so many things, including just feeling like I'm living my day to day life with a purpose.
If you are in that "tinkering" stage right now, please don't give up on medications. There is so much stigma and skepticism out there that can make it hard, but there are meds out there that can help you, even if it takes a while to find the right combination.
Did you notice how she slipped in 'mental illness' while describing depression? If you were confused about depression medication before watching this, you can thank big pharma for letting you know how well these medications "work". I wonder why she didn't mention that these meds permanently changing your brain chemistry so you can't go off of them.
Yea it’s a miserable process .. 8 meds later and still none work.
This video is fair ... well done
Although side effects, Tolerance are dangerous too...
There are some I know doing amazing on them... so far I have to keep suffering
Its probably also important to know that Re-uptake inhibitors, over prolonged periods of time could possibly lead to brain damage due to toxicity in the brain as they continue to block these neurotransmitters from being reabsorbed. In the same way that alcoholism severely damages the brain as it also functions as a re-uptake inhibitor, just on different receptors. So really antidepressants should not be a solution for depression. As such no drug should be permanent in your intake, but used in a way to restructure the connections in your brain and used to train yourself to have different thought patterns that you can sustain off of these antidepressants. When this isn't done it often results in the dosage of whichever SSRI being upped repeatedly and it may become addictive as the body relies on these drugs to have normal functioning levels of the specific neurotransmitter in the brain. I mean i'm no neuroscience but these are certainly real potential dangers that could be unexpected effects of these drugs.
From my experience they are extremely helpful as a 'start' of a therapeutic process. But someone shouldn't just stay there and do nothing else. Psychotherapy should also be a part of this process as well as exercise, good nutrition, maybe even meditation etc. After a while I realized I didn't need meds anymore and so now I use all the other skills I've gained through therapy, continue my exercise etc and I'm succesfully off meds for almost 3 years now!
One of the other misconceptions is that depression always results in sadness or despair, but that's not always true, as was my case. I was having irrational anger and rage because of my anxiety and depression. But people would ask me "are you depressed?" and I'd say "no, I'm just pissed off all the time." I didn't realize that depression could make you angry more than sad. I got on Zoloft about 4 weeks ago and have been so much less angry and irritable. I'm so glad I have this to help me get through a very stressful time in my career and personal life! :-)
I am clinically depressed and I love jokes about depression, so you are incorrect that there is nothing funny about depression. Its actually the ability to laugh at it that helps me most in dealing with it. Dont be afraid to shine a light of humor on to the darkest of topics.
MegaAstroFan18 She made the statement that there's nothing funny about it. The fact that I and so many others with clinical depression (as well as people without it) do actually find it funny seems to indicate otherwise... The statement was incorrect. I understand shes trying not to upset the hypersensitive, but if you say something thats not true in a video thats supposed to be informative..........
Miconception 5: all I need is to pop the drug and be on path to happiness.... Too many people think "I'm depressed" and then ask their general practice M.D for help. The M.D says "let's try this" and the person takes the drug for the 4-6 weeks and reports back to the doctor on how they feel...... Yet during all that time, and further on, people need to be doing cognitive behavioral therapy. Becoming self aware of their thought patterns and learning techniques of introducing new though habits.... It's disgustingly unethical of doctors to participate in drug dealing with no mental training to go with the anti depressants
Not necessarily true, and that's not even close to "disgustingly unethical". In fact, lets keep hyperbole like that out of the discussion if you actually want to have a real discussion.
Some people will be fine with just medication, some people need both. Cognitive therapy was completely useless for me, and actually made my issues worse. But the right medication has worked wonders for me. My mom, similarly, has been just fine with medication alone. There's more stigma towards taking medications, which are spread by comments similar to this one here, than misplaced hope.
Two common, but rarely mentioned effects of SSRIs are nightmares and suppression of libido. Both can be addressed by damiana with varying effectiveness. Then, of course, there are supervised psilocybin sessions, which debilitate the patient for several hours, but are often effective for many months when all maintenance antidepressants have failed.
I have always been sensitive to medication so after 24 hrs i typically feel the effects. Not the full force, just a general change. So by 3 days i can tell if the medication will work for me. Not everyone is the same after all. I recently started prozac about 5 days ago and I can see how it affects my mood and my body. I have taken 5 other types of antidepressants, all other SSRIs and all of them affected me differently too.
I’ve got a friend that is planning to do a podcast about mental illness in an effort to combat a lot of stereotypes and problems in relation to how people with mental illnesses get treated. It’s just a thought, but would someone (preferably the woman that is hosting this clip) be willing to be interviewed by him for his podcast?
Antidepressants are just zombifying you to forget about your problems. Perhaps focus on the reason for your depression and work at fixing it. You're depressed because things in your life suck... change those things instead of getting high or trying to forget. You're welcome.
MegaAstroFan18 Are you saying I'm stupid? As in.. you've bought into the whole, "chemical imbalance" nonsense? If so, I've been severely depressed my whole life... I think I know what I'm talking about. If everything in your life has always been amazing and you're still depressed it's because you have "spoiled child" syndrome. Either way, it can be fixed. People like to think they have some kind of disorder so they feel like they're part of a group... and can also make excuses instead of changing. Everyone and everything can change. Embrace it. The entire psychology industry is based on the idea that, "you have a disorder... take these drugs". It's called free market. If there were a cure for cancer it would never be released because, you know... money.
My med combo causes my entire body to tremble or shake. We don't know why they do this as it's not a common side effect of the meds im takeing. It's not even mentioned on the lists of side effects that come with the medications. Right now the plan is to just keep both meds the same and monitor the trembling. But it continues to get slightly worse every day. I had a sub tell me that im in control of my body so I should stop shakeinh. . . No one else had noticed it but apparently he was watching me write and was watching my hand shake. The thing is, if I try to control it it gets worse. So I just don't control it.
I had a period of depression for some time last year. I had a dog pass away, my job was getting to me, and I was going through a rough time. I never took medication for it or anything like that, but instead I made life changes. Told my manager at work that things were too much there. They gave me another position. And I started feeling lesa depressed. Sure, it took a few days for my body to get used to the change of not being so stressed out and the anxiety and everything, but all in all I felt a lot better. The depression even went away. It took a lot of talking to myself and making life choices. If I didnt change the position I was either going to have to be on these pills or I was going to be quitting the job. Things are better now
I spent a little over a year cycling through different anti depressants before finding the one that worked... it was horrible as I'd suffered with depression for years before going to the doctor and then having to spend all that time waiting for something to work I had pretty much given up hope... on top of that I had to deal with all the different side effects from the different drugs I was given, I already suffer from constant nightmares, but one of the drugs I was put on turned them into terrors, I would wake up screaming and covered in sweat, after a while I just couldn't sleep at all... now though I'm so happy, I don't feel constantly hopeless and alone, I look forward to spending time around people, I've even got a new job which I'm doing amazingly well at. I've had many people tell me that the drugs do nothing, especially while I was bouncing between medications, it was one of the hardest things to hear because without the meds, I'd have nothing.
I dont have money, or health insurance , can barely keep a job , i have a place to sleep thanks to my brother but im getting kicked out probably soon , and i have been ripped off or one doctor told me that , wasted 600$ on talking therapy , almost took my life , now what , no one will take me and its hard to even get in a car to go to a doctor on a place I dont know much about .... Maybe that's why many people don't believe in them ,. Wish I could feel normal , but 2 years have gone and its the same
Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.
Depression Medications (Antidepressants)
These are the most commonly prescribed type of antidepressant.
Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.
SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.
SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.
They are called "selective" because they mainly seem to affect serotonin, and not the other neurotransmitters.