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The different types of mutations | Biomolecules | MCAT | Khan Academy

Оценок: 1906 | Просмотров: 316109
Created by Ross Firestone. Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/biomolecules/genetic-mutations/v/the-causes-of-genetic-mutations?utm_source=YT&utm_medium=Desc&utm_campaign=mcat Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/biomolecules/genetic-mutations/v/an-introduction-to-genetic-mutations?utm_source=YT&utm_medium=Desc&utm_campaign=mcat MCAT on Khan Academy: Go ahead and practice some passage-based questions! About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s MCAT channel: https://www.youtube.com/channel/UCDkK5wqSuwDlJ3_nl3rgdiQ?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
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Текстовые комментарии (61)
Timothy Belen (1 день назад)
Great review for my biology test tomorrow!
joyce bokelo (13 дней назад)
Thanks to you I understood everything perfectly!
Ali Al Hussaini (4 месяца назад)
Thank you very much for this explanation
Ankush Sharma (5 месяцев назад)
nice..
harsha venkat (6 месяцев назад)
thank you so much
Mae D (6 месяцев назад)
transcribed means translated? or decrypted?
Joey (6 месяцев назад)
Sickle cell disease (SCD) or Sickle cell anemia (SCA) The mutation also changes the shape of the hemoglobin to stards. They become sticky and can block the flow of oxygen to the cells.
kpok korean pop (7 месяцев назад)
you're great the video is also great thank you like+subscribe
R T (7 месяцев назад)
Amazing video... Very clear and super informative
Tracy Thibeault (7 месяцев назад)
this is quality, thank you!
Jessica Merrill (8 месяцев назад)
wow this was SO helpful to me, thank you!
vipul malhotra (8 месяцев назад)
Thank you Khan academy!
Ithirstyforknowledge (9 месяцев назад)
From the lecture I couldnt find difference between point mutation and missense . Please tell me the difference?
Danny Joosten (9 месяцев назад)
This guys stole this video from you guys... : https://www.youtube.com/watch?v=qxXRKVompI8
Maryam sweet (9 месяцев назад)
Thanks for those information
stupid tofu (10 месяцев назад)
jesus christ thank you
Missisa G (11 месяцев назад)
This isn't MCAT prep. Its just regular biology prep.
Nao (1 год назад)
I HAD TO SLOW THIS VIDEO DOWN TALK SLOWER MOTHERFUCKER
TheAllen501 (1 год назад)
Thanks a lot!
Balaji saravanan (1 год назад)
awesome dude
Sasha Thomas (1 год назад)
best descriptive understanding I have ever seen, thanks
Youssouf Oumouri (1 год назад)
thanks Allah i want this video becos tomorrow we will have exam hood luck!
Youssouf Oumouri (1 год назад)
gooood work for that thanks you
Aquarithyst (1 год назад)
Oh thank god, I needed this. XD
shishi Rad (1 год назад)
In the frame shift example won't the last G be translated if it's not in a codon?!I mean in order to translate all on RNA should it be having 3n nucleotides so that all of them form codons?!
Arimel09 (7 месяцев назад)
shishi Rad You asked this a long time ago but I don’t know if you ever got your answer. Remember DNA molecules are ~<1,000,000 base pairs long, so if a frame shift mutation occurs closer to the start codon, its effect will be greater than if it had been closer to the Stop codon. Codons are always 3bp long, so in the example the G wasn’t translated only because he didn’t have a longer sequence. So in actual DNA, the codons will keep being translated and transcribed until it reaches a stop codon.
Ice Lysis (1 год назад)
I don't think silent mutations are a subset of missense mutations as you've mentioned. Silent mutations are a part of synonymous mutations; nonsynonymous encompasses missense mutations (which can be conservative/non-conservative), nonsense mutations, and stop-loss mutations (where the stop codon is changed for a coding codon).
east west (2 года назад)
very good explanation thanks
Rafael Viana (2 года назад)
Point mutation is a change in a single nucleotide of a codon, this affects the structure of DNA but the effect it will have in the resulting protein is not specified yet, hence there are several types of point mutation that describe what effect it will have in the protein.
aishwarya khadanga (2 года назад)
clear cut explanation ...helped a lot
HandsomeJack (2 года назад)
Fucking nerd!
Joshua Landrum (2 года назад)
This is so helpful.
Sravya Balasa (2 года назад)
these videos are so helpful thank you!!
Daniel Matheson (2 года назад)
great
squabbit1 (2 года назад)
Kahn Academy has been valuable to me in many areas of my education, but these videos in particular are terrific, because the PACE is right for me. I actually learn better if the video moves along more quickly.
commanderbacara225 (2 года назад)
Step 1 - Click the settings button at the bottom right of the video. Step 2 - Click on the "Speed" Toggle Step 3 - Choose 1.25 or 1.5 Step 4 - ?????? Step 5 - Profit.
Rose B (2 года назад)
I don't understand the difference between point mutation and miss sense don't they both code the wrong base of a codon which changes the amino acid?
Biological Statistics (2 года назад)
Do not interpret them as "different." Rather, missense mutation is a classification of point mutation. There are several ways of picturing point mutations and from an analytical perspective, we first look at their category, then classification. There are more information on mutation than this video covered, and this just an overview on point mutation itself. Get a copy of Lewin Genetics or any molecular genetics textbook really to find out more.
Gayathri Pratha (2 года назад)
I actually understand this 😀
Patrick Tsang (2 года назад)
thanks
Lovedeep Kaur (2 года назад)
Excellent Representation....
Lucious (2 года назад)
This is the most literal "Draw my Life" video
Guillermo Aguilar (2 дня назад)
JAJAJAJAJAJAJAJA
w f (1 год назад)
Hi, could you tell me how to read c.1456G>A or p.Asp486Asn in English?
Nasif Sayeed (3 года назад)
wow.nailed everything in 5 mins!!
Nguyễn Tiến (3 года назад)
Great video. rất dễ hiểu
Mike Birkhead (3 года назад)
Just as others have pointed out, point mutations were oversimplified. But more concerning is the lac of other very common mutations: 1. Translocations 2. Mutations that do not change protein structure, but rather its copy number (non coding mutations) 3. Deletions can be frame shift and non frameshift 4. Insertions : also frame shift and non frame shift 5. Trinucleotide repeat expansions (fragile x syndrome) 6. Epigenetic silencing or up regulations -- not mutations in the traditional sense, but more commonly recognized as mutations in the "histone code" -- and maybe more im not thinking of on top.
Carl Grimes (5 месяцев назад)
Mike Birkhead but the human won't be able to go to Spain.
S Parker (2 года назад)
Yes i see now how its possible XD I asked my bio teacher after posting this, and she said that insertion and deletion will always result in a frame shift. But I can assume that that's just what she wanted us to understand for now.
Mike Birkhead (2 года назад)
+S Parker also, if you delete 3-nucleotides, then there is no frameshift...simply a missing codon.
Mike Birkhead (2 года назад)
+S Parker , one possibility is a deletion in a non-coding portion such as an intron or promoter region. These areas control various aspects about how a genetic sequence is treated by the nuclear machinery, but they do not actually get transcribed... Or if they get transcribed, they are not translated...therefore no codons, therefore, no frameshift. --frameshift refers to how codons are read during translation.
S Parker (2 года назад)
How could deletions and insertions be non frame shift? Sorry, I just learned about genetic mutations.
sunny talpur (3 года назад)
anyone else thinks hes gay? "soo todayyy we gonnaa talk about" LOL
Amer Mh (1 месяц назад)
whats gay with that?
Janice H (3 года назад)
great visual video, attracted me because of your drawing for explanations and great voice for explaining!
dannyville211 (3 года назад)
Very misleading. A point mutations is the big category. Under it are silent, missense and nonsense mutations. This videos makes it look like they are all separate mutations. Wrong. 
Calvin Lee (4 года назад)
so what is the difference between missense mutation and point mutation?f
MasonLegs (8 месяцев назад)
u
Perry Wiseman (1 год назад)
A point mutation is a classification of mutations in which a single codon is substituted. Classically point mutations have three types. Silent mutation is where the third codon (wobble position) is changed but the resulting amino acid does NOT change. This brings up the concept of redundancy. The other types of point mutations are missense (one amino acid changed) and nonsense (premature stop codon) which were termed in the video. Frameshift can be described as a point mutation (insertion or deletion of one codon), but typically textbooks will make a clear distinction between point and frameshift mutations. Two years later, hope that helped lol
yoochanh Hong (4 года назад)
just wow 
Sarah M (4 года назад)
Great video. Fun to watch you draw.

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